Contributions
Abstract: P805
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Background: Theory of Mind (ToM) is a core domain of social cognition (SC). ToM refers to the ability to infer the intentions, thoughts, and beliefs of others and is impaired in multiple sclerosis (MS) in an increasing number of study. Main brain regions engaged in ToM are the medial prefrontal cortex, medial temporal lobe and insula. Functional connectivity (FC) measured by functional MRI (fMRI) is a powerful tool to investigate the mechanisms of cognitive compensation in MS but no study evaluated resting-state fMRI correlates of ToM preservation in MS.
Objectives: To explore resting-state differences in MS patients compared to healthy controls (HC) and to correlate these findings with SC tests.
Methods: We performed a FC analysis using the CONN toolbox to test for differential connectivity patterns between 20 individuals with relapsing-remitting MS (RRMS) and 15 HC. We mapped resting-state fMRI data onto regions of interest (ROIs) of resting state networks (Default Mode, Salience, Dorsal Attention, Frontoparietal and Cerebellar). Resulting ROI-to-ROI connections for which we determined total linear temporal associations between each were compared between the two groups. SC was assessed using both the ToM (TOM-15) and faux pas recognition (FP) tests. Within the RRMS group, we further tested the association between ToM performances and altered FC.
Results: Increased FC was noticed between the default mode and the salience networks in RRMS patients compared to HC, whereas decreased FC was observed within the salience network and between the anterior cerebellar and the dorsal attention networks.
RRMS patients demonstrated normal TOM-15 and FP scores compared to HC.
The anterior cerebellar-dorsal attention FC explained (R2adj=33%) the TOM-15 test performances (beta=-0.92), while the default mode-salience FC explained (R2adj=32%) the FP test performances (beta=-0.73). These associations were not found in HC.
Conclusion: Select resting state networks show altered functional connectivity in RRMS patients. These brain networks alterations were associated with SC performances in MS patients suggesting a brain connectivity reorganization to obtain normal SC results.
Disclosure: This study was supported by La ligue française contre la sclérose en plaques.
Koubiyr I: Personal grant from TRAIL.Deloire M: Nothing to disclose.
Ruet A: Dr A Ruet or her institution received honoraria for consulting, speaking at scientific symposia, serving in advisory board or research support from Biogen Idec, Medday, Merck Serono, Novartis, Roche, Sanofi-Genzyme, Teva (all with approval by general director of the Hospital of Bordeaux and the University of Bordeaux).
Charre-Morin J: Nothing to disclose.
Saubusse A: Nothing to disclose.
Brochet B: Pr Brochet or its institution received honoraria for consulting, speaking at scientific symposia, serving in advisory board or research support from Actelion, Biogen Idec, Merck Serono, Sanofi-Genzyme, Bayer, Medday, Roche, Teva, Novartis (all with approval by general director CHU de Bordeaux).
Dulau C: Dr Dulau received honoraria for speaking at scientific symposia by Biogen, Genzyme, Novartis and Teva.
Abstract: P805
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - MRI and PET
Background: Theory of Mind (ToM) is a core domain of social cognition (SC). ToM refers to the ability to infer the intentions, thoughts, and beliefs of others and is impaired in multiple sclerosis (MS) in an increasing number of study. Main brain regions engaged in ToM are the medial prefrontal cortex, medial temporal lobe and insula. Functional connectivity (FC) measured by functional MRI (fMRI) is a powerful tool to investigate the mechanisms of cognitive compensation in MS but no study evaluated resting-state fMRI correlates of ToM preservation in MS.
Objectives: To explore resting-state differences in MS patients compared to healthy controls (HC) and to correlate these findings with SC tests.
Methods: We performed a FC analysis using the CONN toolbox to test for differential connectivity patterns between 20 individuals with relapsing-remitting MS (RRMS) and 15 HC. We mapped resting-state fMRI data onto regions of interest (ROIs) of resting state networks (Default Mode, Salience, Dorsal Attention, Frontoparietal and Cerebellar). Resulting ROI-to-ROI connections for which we determined total linear temporal associations between each were compared between the two groups. SC was assessed using both the ToM (TOM-15) and faux pas recognition (FP) tests. Within the RRMS group, we further tested the association between ToM performances and altered FC.
Results: Increased FC was noticed between the default mode and the salience networks in RRMS patients compared to HC, whereas decreased FC was observed within the salience network and between the anterior cerebellar and the dorsal attention networks.
RRMS patients demonstrated normal TOM-15 and FP scores compared to HC.
The anterior cerebellar-dorsal attention FC explained (R2adj=33%) the TOM-15 test performances (beta=-0.92), while the default mode-salience FC explained (R2adj=32%) the FP test performances (beta=-0.73). These associations were not found in HC.
Conclusion: Select resting state networks show altered functional connectivity in RRMS patients. These brain networks alterations were associated with SC performances in MS patients suggesting a brain connectivity reorganization to obtain normal SC results.
Disclosure: This study was supported by La ligue française contre la sclérose en plaques.
Koubiyr I: Personal grant from TRAIL.Deloire M: Nothing to disclose.
Ruet A: Dr A Ruet or her institution received honoraria for consulting, speaking at scientific symposia, serving in advisory board or research support from Biogen Idec, Medday, Merck Serono, Novartis, Roche, Sanofi-Genzyme, Teva (all with approval by general director of the Hospital of Bordeaux and the University of Bordeaux).
Charre-Morin J: Nothing to disclose.
Saubusse A: Nothing to disclose.
Brochet B: Pr Brochet or its institution received honoraria for consulting, speaking at scientific symposia, serving in advisory board or research support from Actelion, Biogen Idec, Merck Serono, Sanofi-Genzyme, Bayer, Medday, Roche, Teva, Novartis (all with approval by general director CHU de Bordeaux).
Dulau C: Dr Dulau received honoraria for speaking at scientific symposia by Biogen, Genzyme, Novartis and Teva.