Contributions
Abstract: P731
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Comorbidity
Introduction: Multiple sclerosis (MS) is an inflammatory disorder of central nervous system. Inflammation is present in all stages of multiple sclerosis and may create high susceptibility to subclinical atherosclerosis. Atherosclerosis is a complicated process with multifactorial etiology and involves inflammatory, fibroproliferative and angiogenic responses. It is a chronic inflammatory process of the arterial wall and carotid intima-media thickness (cIMT) is regarded as its early marker. The purpose of this study was to compare subclinical atherosclerosis between patients with relapsing-remitting multiple sclerosis (RR MS) treated with disease modifying drugs and healty control subjects matched for age and sex.
Methods: The study group comprised of 112 non-diabetic and non-hypertensive RR MS patients treated with disease modifying drugs. Fifty healthy subjects matched by age and sex, were selected as a control group from hospital personnel. We investigated IMT in the common carotid arteries (CCA). Three digitalized ultrasound still images from the same section of the artery were measured and average value calculated. We also evaluated patients using Multiple Sclerosis Functional Composite (MSFC) and Expanded Disability Status Scale (EDSS).
Results: Mean CCA IMT (0.572 ± 0.131 vs. 0.566 ± 0.106) did not differ (p > 0.05) between patients (mean age 40.66 ± 8.95) and controls (mean age 40.67 ± 9.84). Patient's age was correlated with CCA IMT (p < 0.01). There was also a statistically significant correlation between the Timed 25-Foot Walk (T25-FW), one of the three MSFC components, and CCA IMT (p < 0.01). There was no statistically significant correlation between EDSS and CCA IMT (p > 0.05).
Conclusion: There was no statistically significant difference in cIMT between patients with RR MS treated with disease modifying drugs and healthy controls. We found statistically significant correlation between the T25-FW and CCA IMT.
Disclosure: Omerzu Tomaž: nothing to disclose, Magdič Jožef: nothing to disclose, Hojs Radovan: nothing to disclose, Hojs Fabjan Tanja: nothing to disclose
Abstract: P731
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Comorbidity
Introduction: Multiple sclerosis (MS) is an inflammatory disorder of central nervous system. Inflammation is present in all stages of multiple sclerosis and may create high susceptibility to subclinical atherosclerosis. Atherosclerosis is a complicated process with multifactorial etiology and involves inflammatory, fibroproliferative and angiogenic responses. It is a chronic inflammatory process of the arterial wall and carotid intima-media thickness (cIMT) is regarded as its early marker. The purpose of this study was to compare subclinical atherosclerosis between patients with relapsing-remitting multiple sclerosis (RR MS) treated with disease modifying drugs and healty control subjects matched for age and sex.
Methods: The study group comprised of 112 non-diabetic and non-hypertensive RR MS patients treated with disease modifying drugs. Fifty healthy subjects matched by age and sex, were selected as a control group from hospital personnel. We investigated IMT in the common carotid arteries (CCA). Three digitalized ultrasound still images from the same section of the artery were measured and average value calculated. We also evaluated patients using Multiple Sclerosis Functional Composite (MSFC) and Expanded Disability Status Scale (EDSS).
Results: Mean CCA IMT (0.572 ± 0.131 vs. 0.566 ± 0.106) did not differ (p > 0.05) between patients (mean age 40.66 ± 8.95) and controls (mean age 40.67 ± 9.84). Patient's age was correlated with CCA IMT (p < 0.01). There was also a statistically significant correlation between the Timed 25-Foot Walk (T25-FW), one of the three MSFC components, and CCA IMT (p < 0.01). There was no statistically significant correlation between EDSS and CCA IMT (p > 0.05).
Conclusion: There was no statistically significant difference in cIMT between patients with RR MS treated with disease modifying drugs and healthy controls. We found statistically significant correlation between the T25-FW and CCA IMT.
Disclosure: Omerzu Tomaž: nothing to disclose, Magdič Jožef: nothing to disclose, Hojs Radovan: nothing to disclose, Hojs Fabjan Tanja: nothing to disclose