Contributions
Abstract: P709
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: Multiple Sclerosis (MS) is a chronic condition that may lead to important physical and cognitive disability. Cognition is affected from early stages of disease and is related to brain atrophy, specially in the thalamus. Currently, we lack readily available methods for measuring brain volume loss (BVL) in daily practice.
Objectives: To evaluate brain atrophy (defined as III ventricle width (TVW)) by means of transcranial duplex (TD) and to correlate these values with cognitive assessments in a cohort of patients with early MS.
Methods: MS patients were consecutively recruited from the MS clinic in Hospital Universitario Gregorio Marañon (Madrid). TVW was measured in millimetres using a Toshiba Xario® DT using a 2 MHz probe. Cognition was assessed with the 9 Hole-Peg Test, Symbol-Digit Modality Test (SDMT), Brief Visual-Memory Test, Paced Auditory Serial Addition Task and the Spanish version of the California Learning Verbal Test. Demographical, clinical and radiological characteristics were collected.
Results: Thirty-one healthy controls were matched by sex, age and education level as reference population for TD. Sixty-one patients with early MS (mean disease duration 37 months (±27), mean EDSS 1,3(±1,29)) were recruited. Cognitive impairment was found in 42,6% of the MS patients (32,8% mild, 9,8% moderate). Mean TVW was significantly larger in MS patients than in controls (2,64mm ±0,19 vs 1,74mm ±0,12; p< 0,001), but no correlation was found with either age, EDSS, SDMT or cognitive status.
Conclusions: In our sample, cognitive impairment was frequent despite a short duration of MS. TVW was larger in patients, supporting that brain atrophy begins early in the disease. Further studies are warranted to evaluate the role of TVW to measure atrophy in MS in a simple way and its relation with certain cognitive profiles.
Disclosure: This study was funded by Novartis®
Abstract: P709
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Introduction: Multiple Sclerosis (MS) is a chronic condition that may lead to important physical and cognitive disability. Cognition is affected from early stages of disease and is related to brain atrophy, specially in the thalamus. Currently, we lack readily available methods for measuring brain volume loss (BVL) in daily practice.
Objectives: To evaluate brain atrophy (defined as III ventricle width (TVW)) by means of transcranial duplex (TD) and to correlate these values with cognitive assessments in a cohort of patients with early MS.
Methods: MS patients were consecutively recruited from the MS clinic in Hospital Universitario Gregorio Marañon (Madrid). TVW was measured in millimetres using a Toshiba Xario® DT using a 2 MHz probe. Cognition was assessed with the 9 Hole-Peg Test, Symbol-Digit Modality Test (SDMT), Brief Visual-Memory Test, Paced Auditory Serial Addition Task and the Spanish version of the California Learning Verbal Test. Demographical, clinical and radiological characteristics were collected.
Results: Thirty-one healthy controls were matched by sex, age and education level as reference population for TD. Sixty-one patients with early MS (mean disease duration 37 months (±27), mean EDSS 1,3(±1,29)) were recruited. Cognitive impairment was found in 42,6% of the MS patients (32,8% mild, 9,8% moderate). Mean TVW was significantly larger in MS patients than in controls (2,64mm ±0,19 vs 1,74mm ±0,12; p< 0,001), but no correlation was found with either age, EDSS, SDMT or cognitive status.
Conclusions: In our sample, cognitive impairment was frequent despite a short duration of MS. TVW was larger in patients, supporting that brain atrophy begins early in the disease. Further studies are warranted to evaluate the role of TVW to measure atrophy in MS in a simple way and its relation with certain cognitive profiles.
Disclosure: This study was funded by Novartis®