
Contributions
Abstract: P694
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Sexual dysfunction (SD) can affect 40% to 80% of female patients with multiple sclerosis (pwMS), which negatively impacts women´s quality of life; however, little is known about its prevalence in clinically isolated syndrome (CIS).
Objectives: To address the frequency and pattern of SD dimensions in women with CIS.
Methods: Cross-sectional descriptive study from August 2011 to June 2017 on CIS women according to McDonalds criteria, 2010 (n=43, age 18-48). Sexually inactive women, post-menopausal; or those with endocrinal disorders or medications which affect sexual activity were excluded.
A comprehensive clinical evaluation was done at least 8 weeks after corticosteroid intake and before starting any disease modifying drugs. All patients were subjected to the self-reported “Multiple Sclerosis Intimacy and Sexuality Questionnaire” (MSISQ-19). Fatigue was assessed by 'Fatigue Scale for Motor and Cognitive Functions', and depression was evaluated by 'Hospital Anxiety and Depression Scale'. Radiological findings were compared between those with and those without SD.
Results: Mean patients age (24.71±3.55) years. Sexual dysfunctions were reported by 24/43 (55.81%), which included primary SD in 19/43 (44.19%); secondary SD in 7/43 (16.28%) and tertiary SD in 5/43 (11.63%). History of SD was reported before neurologic deficits in 4 women. The most common primary SD manifestations were lack of sexual interest/desire in 8/19 (42.11%), less intense orgasm/climax in 5/19 (26.32%) and inadequate vaginal lubrication in 4/19 (21.05%). Secondary SD was related to problems with concentration and memory in 4/7, urinary/bowel symptoms in 5/7 and pain/discomfort in body in 3/7. Tertiary SD was mostly related to lack of confidence about sexuality and fear of rejection. Women with SD were significantly older (27.51 ± 2.04 vs. 23.12 ± 1.19; P = 0.002), but there were no significant relations with educational level or occupation. Fatigue (OR = 2.09, 95% CI: 1.57-4.46, P = 0.006) and depression (OR = 2.79, 95% CI: 1.52-3.99, P = 0.002) were significant predictors.
No statistical difference in MRI brain/spine lesions locations between both groups of patients (P.0.05).
Conclusion: SD is a common multifactorial manifestation in women with CIS and it may predate frank neurological symptoms.
Disclosure: Nevin M. Shalaby: nothing to disclose
Maged Abdel-Naseer: nothing to disclose
Amr Hassan: nothing to disclose
Alaa Elmazny: nothing to disclose
Hatem S. Shehata: nothing to disclose
Abstract: P694
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Sexual dysfunction (SD) can affect 40% to 80% of female patients with multiple sclerosis (pwMS), which negatively impacts women´s quality of life; however, little is known about its prevalence in clinically isolated syndrome (CIS).
Objectives: To address the frequency and pattern of SD dimensions in women with CIS.
Methods: Cross-sectional descriptive study from August 2011 to June 2017 on CIS women according to McDonalds criteria, 2010 (n=43, age 18-48). Sexually inactive women, post-menopausal; or those with endocrinal disorders or medications which affect sexual activity were excluded.
A comprehensive clinical evaluation was done at least 8 weeks after corticosteroid intake and before starting any disease modifying drugs. All patients were subjected to the self-reported “Multiple Sclerosis Intimacy and Sexuality Questionnaire” (MSISQ-19). Fatigue was assessed by 'Fatigue Scale for Motor and Cognitive Functions', and depression was evaluated by 'Hospital Anxiety and Depression Scale'. Radiological findings were compared between those with and those without SD.
Results: Mean patients age (24.71±3.55) years. Sexual dysfunctions were reported by 24/43 (55.81%), which included primary SD in 19/43 (44.19%); secondary SD in 7/43 (16.28%) and tertiary SD in 5/43 (11.63%). History of SD was reported before neurologic deficits in 4 women. The most common primary SD manifestations were lack of sexual interest/desire in 8/19 (42.11%), less intense orgasm/climax in 5/19 (26.32%) and inadequate vaginal lubrication in 4/19 (21.05%). Secondary SD was related to problems with concentration and memory in 4/7, urinary/bowel symptoms in 5/7 and pain/discomfort in body in 3/7. Tertiary SD was mostly related to lack of confidence about sexuality and fear of rejection. Women with SD were significantly older (27.51 ± 2.04 vs. 23.12 ± 1.19; P = 0.002), but there were no significant relations with educational level or occupation. Fatigue (OR = 2.09, 95% CI: 1.57-4.46, P = 0.006) and depression (OR = 2.79, 95% CI: 1.52-3.99, P = 0.002) were significant predictors.
No statistical difference in MRI brain/spine lesions locations between both groups of patients (P.0.05).
Conclusion: SD is a common multifactorial manifestation in women with CIS and it may predate frank neurological symptoms.
Disclosure: Nevin M. Shalaby: nothing to disclose
Maged Abdel-Naseer: nothing to disclose
Amr Hassan: nothing to disclose
Alaa Elmazny: nothing to disclose
Hatem S. Shehata: nothing to disclose