Contributions
Abstract: P685
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Due to the evidence suggesting oxidative stress role in the pathogenesis of multiple sclerosis (MS), it has been postulated that higher levels of uric acid (UA), a natural peroxynitrite scavenger and endogenous antioxidant, could reduce or influence the disease progression. In addition, cigarette smoking, as a well-established environmental risk factor associated with the incidence and progression of MS, has been reported to reduce serum UA in healthy individuals. The objective of this study was to analyse the effect of smoking on serum UA levels before and after smoking cessation, as well as the correlation of serum UA levels with both disability and disease severity.
Methods: In this study, 127 participants were identified from Nottingham University Hospital MS clinics database. Serum UA levels, smoking status and the clinical outcomes, including Multiple Sclerosis Severity Score (MSSS), Expanded Disability Status Scale (EDSS) Multiple Sclerosis Impact Scale (MSIS-29) scores and others were obtained. The comparison between current smokers, non-smokers and ex-smokers in UA levels were applied by analysis of variance (ANOVA). Linear regression analyses were used to determine the correlation of UA levels with the disease severity and the level of disability.
Results: We found that serum UA was significantly lower in current smokers than in ex-smokers (p = 0.02) but not in non-smokers (p = 0.09). In addition, we found no correlation between serum UA levels and the level of disability or disease severity.
Conclusion: The low plasma UA levels in current smokers was connected to a reduction of its endogenous production because of the chronic exposure to cigarette smoke, which restored upon smoking cessation, and that is influencing the process of oxidative stress and may involve in the underlying mechanisms of many diseases including MS. The UA levels may be not a good marker for the level of disability or severity of MS; however, further studies will follow with a larger participants numbers to assess the association of smoking and UA levels as well as the correlation with the clinical outcomes taking account and adjusting for confounders.
Disclosure: Mohammed Alrouji and Bruno Gran had nothing to disclose. Cris S Constantinescu has been supported by MS Society of Great Britain and Northern Ireland and the Forman Hardy Charitable Trust via the University of Nottingham.
Abstract: P685
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Background: Due to the evidence suggesting oxidative stress role in the pathogenesis of multiple sclerosis (MS), it has been postulated that higher levels of uric acid (UA), a natural peroxynitrite scavenger and endogenous antioxidant, could reduce or influence the disease progression. In addition, cigarette smoking, as a well-established environmental risk factor associated with the incidence and progression of MS, has been reported to reduce serum UA in healthy individuals. The objective of this study was to analyse the effect of smoking on serum UA levels before and after smoking cessation, as well as the correlation of serum UA levels with both disability and disease severity.
Methods: In this study, 127 participants were identified from Nottingham University Hospital MS clinics database. Serum UA levels, smoking status and the clinical outcomes, including Multiple Sclerosis Severity Score (MSSS), Expanded Disability Status Scale (EDSS) Multiple Sclerosis Impact Scale (MSIS-29) scores and others were obtained. The comparison between current smokers, non-smokers and ex-smokers in UA levels were applied by analysis of variance (ANOVA). Linear regression analyses were used to determine the correlation of UA levels with the disease severity and the level of disability.
Results: We found that serum UA was significantly lower in current smokers than in ex-smokers (p = 0.02) but not in non-smokers (p = 0.09). In addition, we found no correlation between serum UA levels and the level of disability or disease severity.
Conclusion: The low plasma UA levels in current smokers was connected to a reduction of its endogenous production because of the chronic exposure to cigarette smoke, which restored upon smoking cessation, and that is influencing the process of oxidative stress and may involve in the underlying mechanisms of many diseases including MS. The UA levels may be not a good marker for the level of disability or severity of MS; however, further studies will follow with a larger participants numbers to assess the association of smoking and UA levels as well as the correlation with the clinical outcomes taking account and adjusting for confounders.
Disclosure: Mohammed Alrouji and Bruno Gran had nothing to disclose. Cris S Constantinescu has been supported by MS Society of Great Britain and Northern Ireland and the Forman Hardy Charitable Trust via the University of Nottingham.