Contributions
Abstract: P540
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Biomarkers
Introduction: Evoked potentials (EP) are useful for the diagnosis of multiple sclerosis (MS), but they are not mandatory. Previous studies suggest that they could be more useful in long-term prognosis. On the other hand, brain volume has a better association with disability than T2 lesion burden.
Objetives: In this study, we asses for the first time whether there is an association between EP results and magnetic resonance imaging (MRI) measures and if both tools used together would improve the prognostic value.
Methods: MS patients were randomly recruited along three months. We collected their EP results at diagnosis: visual evoked potentials, brain stem auditory evoked potentials, somatosensory evoked potentials and motor evoked potentials (MEP) and combined results: the evoked potential abnormality score (EPAS). In addition, we quantified number and volume of T2 lesions, black holes, number of enhancing lesions and number of spinal lesions with JIM software and whole brain (WB), white matter and gray matter (GM) volume with SIENAX. We collected the evolution of the disability measured by Expanded Disability Status Scale (EDSS) too. Correlations between MRI measures, EP results and EDSS were evaluated using correlation coefficients.
Results: We included 60 MS patients (39 were women). Among all variables tested, MEP results had the highest correlation coefficient with the disability (for average central conduction times with EDDS in the fifth year: R= 0.516, p< 0,01). The correlations with the disability improved when we used combined scale (EPAS) (in the fifth year: R=0,514, p< 0,01). We found the best correlations among all MRI and EP variables for MEP of lower limbs: average central conduction times with volume of T2 lesions (R=0,301, p< 0,05), WB volume (R=-0,306, p< 0,05), GM volume (R=-0,319, p< 0,05) and average of amplitudes with volume of T1 lesions (R=-0,499, p< 0,05), WB volume (R=0,726, p< 0,01) and GM volume (R=0,597, p< 0,01). We found significant positive correlations (p< 0,05) between EPAS results and T2 lesions, black holes and spinal lesions.
Conclusions: Early alterations in EP have a long-term predictive value. MEP data and EPAS score showed the best correlations with disability, better even than WB and GM volume. EP could be useful as predictors of neurodegeneration given the correlations with MRI parameters. The combination of both tools might be useful to determinate the risk of individual progression.
Disclosure: Reyes Garrido V. : Nothing to disclose.
Fernández Sánchez V.E .:Nothing to disclose.
Castro Sánchez M.V. : Nothing to disclose.
Alonso Torres A.M. : Nothing to disclose.
Postigo Pozo M.J. : Nothing to disclose.
Villagrán García M. : Nothing to disclose.
Ciano Petersen N.L. : Nothing to disclose.
Pons Pons G. : Nothing to disclose.
Guerrero Fernández M.M. : Nothing to disclose.
León Martín A. : Nothing to disclose.
Muñoz Ruiz T. : Nothing to disclose.
Urbaneja Romero P. : Nothing to disclose.
Serrano Castro P.J. :Nothing to disclose.
Fernández Fernández Ó. : Nothing to disclose.
Abstract: P540
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Biomarkers
Introduction: Evoked potentials (EP) are useful for the diagnosis of multiple sclerosis (MS), but they are not mandatory. Previous studies suggest that they could be more useful in long-term prognosis. On the other hand, brain volume has a better association with disability than T2 lesion burden.
Objetives: In this study, we asses for the first time whether there is an association between EP results and magnetic resonance imaging (MRI) measures and if both tools used together would improve the prognostic value.
Methods: MS patients were randomly recruited along three months. We collected their EP results at diagnosis: visual evoked potentials, brain stem auditory evoked potentials, somatosensory evoked potentials and motor evoked potentials (MEP) and combined results: the evoked potential abnormality score (EPAS). In addition, we quantified number and volume of T2 lesions, black holes, number of enhancing lesions and number of spinal lesions with JIM software and whole brain (WB), white matter and gray matter (GM) volume with SIENAX. We collected the evolution of the disability measured by Expanded Disability Status Scale (EDSS) too. Correlations between MRI measures, EP results and EDSS were evaluated using correlation coefficients.
Results: We included 60 MS patients (39 were women). Among all variables tested, MEP results had the highest correlation coefficient with the disability (for average central conduction times with EDDS in the fifth year: R= 0.516, p< 0,01). The correlations with the disability improved when we used combined scale (EPAS) (in the fifth year: R=0,514, p< 0,01). We found the best correlations among all MRI and EP variables for MEP of lower limbs: average central conduction times with volume of T2 lesions (R=0,301, p< 0,05), WB volume (R=-0,306, p< 0,05), GM volume (R=-0,319, p< 0,05) and average of amplitudes with volume of T1 lesions (R=-0,499, p< 0,05), WB volume (R=0,726, p< 0,01) and GM volume (R=0,597, p< 0,01). We found significant positive correlations (p< 0,05) between EPAS results and T2 lesions, black holes and spinal lesions.
Conclusions: Early alterations in EP have a long-term predictive value. MEP data and EPAS score showed the best correlations with disability, better even than WB and GM volume. EP could be useful as predictors of neurodegeneration given the correlations with MRI parameters. The combination of both tools might be useful to determinate the risk of individual progression.
Disclosure: Reyes Garrido V. : Nothing to disclose.
Fernández Sánchez V.E .:Nothing to disclose.
Castro Sánchez M.V. : Nothing to disclose.
Alonso Torres A.M. : Nothing to disclose.
Postigo Pozo M.J. : Nothing to disclose.
Villagrán García M. : Nothing to disclose.
Ciano Petersen N.L. : Nothing to disclose.
Pons Pons G. : Nothing to disclose.
Guerrero Fernández M.M. : Nothing to disclose.
León Martín A. : Nothing to disclose.
Muñoz Ruiz T. : Nothing to disclose.
Urbaneja Romero P. : Nothing to disclose.
Serrano Castro P.J. :Nothing to disclose.
Fernández Fernández Ó. : Nothing to disclose.