Contributions
Abstract: P440
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Immunology
Introduction: Potential cerebrospinal fluid (CSF) and serum candidate biomarkers, reflecting the inflammatory and/or the neurodegenerative processes associated with multiple sclerosis (MS) have been identified, but have not been well characterized in patients with primary progressive multiple sclerosis (PPMS)
Objective: To assess the correlation between CSF biomarkers and disease activity (physical and cognitive) in PPMS.
Methods: A multicentre, cross-sectional study was conducted in a sample of adult patients with PPMS (McDonald 2010 criteria). Chitinase-3-like protein 1 and 2 (CHI3L1 and CHI3L2) and neurofilament light chain (NfL) were analysed in stored CSF samples obtained at the time of diagnosis and correlated to disability progression measured by Expanded Disability Status Scale (EDSS), 9-Hole-peg test (9HPT) and timed 25-foot walk test (T25-FW) and cognitive evaluation measured by brief repeatable neurophyscological battery (BRNB.)
Results: Twenty-five out of 55 subjects had availability of CSF samples for study (mean age 57 ± 9.4 years, 52% female). The median time from diagnosis to baseline EDSS was 3.5 years (IQR 1.2-6.4), and the median Expanded Disability Status Scale (EDSS) score at diagnosis was 3.5 (interquartile range 2.5-4.5). CHI3L1 levels were associated to a greater EDSS at baseline (correlation coefficient 0.490, p=0.013). Furthermore, a trend to a negative correlation was observed with CHI3L2 and EDSS (correlation coefficient -0.366, P= 0.086). No other correlations, including NfL, were observed.
Conclusion: CHI3L1 in CSF could be a good biomarker for disability progression in PPMS patients. NfL levels in CSF were not related with the evolution of disability in our series of PPMS patients.
Disclosure: This study was funded by the Medical Department of Roche Farma Spain. D.P. and N.M. are employees of Roche Farma Spain. The rest of the authors declare no potential conflict of interest.
Abstract: P440
Type: Poster Sessions
Abstract Category: Pathology and pathogenesis of MS - Immunology
Introduction: Potential cerebrospinal fluid (CSF) and serum candidate biomarkers, reflecting the inflammatory and/or the neurodegenerative processes associated with multiple sclerosis (MS) have been identified, but have not been well characterized in patients with primary progressive multiple sclerosis (PPMS)
Objective: To assess the correlation between CSF biomarkers and disease activity (physical and cognitive) in PPMS.
Methods: A multicentre, cross-sectional study was conducted in a sample of adult patients with PPMS (McDonald 2010 criteria). Chitinase-3-like protein 1 and 2 (CHI3L1 and CHI3L2) and neurofilament light chain (NfL) were analysed in stored CSF samples obtained at the time of diagnosis and correlated to disability progression measured by Expanded Disability Status Scale (EDSS), 9-Hole-peg test (9HPT) and timed 25-foot walk test (T25-FW) and cognitive evaluation measured by brief repeatable neurophyscological battery (BRNB.)
Results: Twenty-five out of 55 subjects had availability of CSF samples for study (mean age 57 ± 9.4 years, 52% female). The median time from diagnosis to baseline EDSS was 3.5 years (IQR 1.2-6.4), and the median Expanded Disability Status Scale (EDSS) score at diagnosis was 3.5 (interquartile range 2.5-4.5). CHI3L1 levels were associated to a greater EDSS at baseline (correlation coefficient 0.490, p=0.013). Furthermore, a trend to a negative correlation was observed with CHI3L2 and EDSS (correlation coefficient -0.366, P= 0.086). No other correlations, including NfL, were observed.
Conclusion: CHI3L1 in CSF could be a good biomarker for disability progression in PPMS patients. NfL levels in CSF were not related with the evolution of disability in our series of PPMS patients.
Disclosure: This study was funded by the Medical Department of Roche Farma Spain. D.P. and N.M. are employees of Roche Farma Spain. The rest of the authors declare no potential conflict of interest.