Contributions
Abstract: P390
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple sclerosis is an heterogenous disease, in which disability depends on the evolution time. Brain and spinal cord atrophy have been found to be predictors of the forthcoming disability.
Objective: To explore the relationship between brain and spinal cord atrophy with the disability, measured as the Expanded Disability Status Scale (EDSS) and as the time-related disability measured by the Multiple Sclerosis Severity Score (MSSS).
Method: The brain and cervical spinal cord atrophy were measured in 63 consecutive MS patients with 3T magnetic resonance imaging (MRI). Brain volume measures were calculated with FreeSurfer and spinal cord volumes were segmented manually. Clinical forms, the EDSS, and the MSSS were recorded at the time of the MRI scans and the correlation between brain atrophy measures, spinal cord atrophy, and clinical measures were obtained.
Results: Sixty-three MS patients were studied (73% females). Fifty-two relapsing-remitting MS and 11 secondary progressive patients. Mean age 40.1 (SD 10.6), evolution 12.1 years (SD 8.5), EDSS 2.6 (SD 1.4), MSSS 3.1 (SD 3.1). Brain parenchymal fraction, the cortical grey matter, cerebellum, brain stem, and cervical cord volumes correlated with the EDSS, but only the cervical spinal cord volume correlated negatively with the MSSS (Spermann Rank correlation -0.359, p=0.008). Similar results were found when excluding SPMS patients from the analyses (Spearmann Rank correlation -0.336, p=0.014).
Conclusions: Although several brain volume measurements correlate with the concurrent EDSS, only the spinal cord atrophy seems to encompass the disability adjusted by the time of evolution, reflected by the MSSS scale. Our results appoint to the necessity of measuring the spinal cord atrophy as a marker of continuous degeneration in MS.
Disclosure: The authors have not disclosures to declare
Abstract: P390
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Clinical assessment tools
Background: Multiple sclerosis is an heterogenous disease, in which disability depends on the evolution time. Brain and spinal cord atrophy have been found to be predictors of the forthcoming disability.
Objective: To explore the relationship between brain and spinal cord atrophy with the disability, measured as the Expanded Disability Status Scale (EDSS) and as the time-related disability measured by the Multiple Sclerosis Severity Score (MSSS).
Method: The brain and cervical spinal cord atrophy were measured in 63 consecutive MS patients with 3T magnetic resonance imaging (MRI). Brain volume measures were calculated with FreeSurfer and spinal cord volumes were segmented manually. Clinical forms, the EDSS, and the MSSS were recorded at the time of the MRI scans and the correlation between brain atrophy measures, spinal cord atrophy, and clinical measures were obtained.
Results: Sixty-three MS patients were studied (73% females). Fifty-two relapsing-remitting MS and 11 secondary progressive patients. Mean age 40.1 (SD 10.6), evolution 12.1 years (SD 8.5), EDSS 2.6 (SD 1.4), MSSS 3.1 (SD 3.1). Brain parenchymal fraction, the cortical grey matter, cerebellum, brain stem, and cervical cord volumes correlated with the EDSS, but only the cervical spinal cord volume correlated negatively with the MSSS (Spermann Rank correlation -0.359, p=0.008). Similar results were found when excluding SPMS patients from the analyses (Spearmann Rank correlation -0.336, p=0.014).
Conclusions: Although several brain volume measurements correlate with the concurrent EDSS, only the spinal cord atrophy seems to encompass the disability adjusted by the time of evolution, reflected by the MSSS scale. Our results appoint to the necessity of measuring the spinal cord atrophy as a marker of continuous degeneration in MS.
Disclosure: The authors have not disclosures to declare