Contributions
Abstract: P376
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Movement disorders are thought to be rare in MS, however, many retrospective studies and review articles suggest that the prevalence is under-estimated. Moreover, the clinical characteristics of movement disorders have never been evaluated prospectively in patients with primary progressive MS (PPMS).
Objectives: To prospectively evaluate the prevalence and clinical characteristics of movement disorders in a sample of patients with PPMS.
Methods: A consecutive sample of PPMS was evaluated by a movement disorder specialist who carried out a standardized movement disorder questionnaire and performed a movement disorders-focused neurological exam. This study is still currently recruiting.
Results: Twenty PPMS were recruited so far (mean age 56.4 years, mean disease duration 12.2 years, 30% males). Movement disorders were present in 95% of the patients. the most common movement disorders were: action tremor 50%, tonic spasms 40%, focal dystonia 40%, myoclonus 30%, RLS 25%, spontaneous clonus 15%, demyelination-related parkinsonism 5%, fasciculation 5%, hemifacial spasm 5%. The movement disorders were spinal in origin in 60% of the patients, cerebellar in 25%, and ganglionic in 15%.
Conclusion: Movement disorders are very frequent in patients with PPMS and are often spinal or cerebellar in origin. Ganglionic movement disorders are much more common in PPMS compared to our previously-studied group of RRMS patients.
Disclosure: Dr. Abboud is a consultant for Biogen and Genentech. Ms. Woodson is a speaker for Genentech and Biogen. Dr. Serra is a consultant for Biogen.
Abstract: P376
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS symptoms
Introduction: Movement disorders are thought to be rare in MS, however, many retrospective studies and review articles suggest that the prevalence is under-estimated. Moreover, the clinical characteristics of movement disorders have never been evaluated prospectively in patients with primary progressive MS (PPMS).
Objectives: To prospectively evaluate the prevalence and clinical characteristics of movement disorders in a sample of patients with PPMS.
Methods: A consecutive sample of PPMS was evaluated by a movement disorder specialist who carried out a standardized movement disorder questionnaire and performed a movement disorders-focused neurological exam. This study is still currently recruiting.
Results: Twenty PPMS were recruited so far (mean age 56.4 years, mean disease duration 12.2 years, 30% males). Movement disorders were present in 95% of the patients. the most common movement disorders were: action tremor 50%, tonic spasms 40%, focal dystonia 40%, myoclonus 30%, RLS 25%, spontaneous clonus 15%, demyelination-related parkinsonism 5%, fasciculation 5%, hemifacial spasm 5%. The movement disorders were spinal in origin in 60% of the patients, cerebellar in 25%, and ganglionic in 15%.
Conclusion: Movement disorders are very frequent in patients with PPMS and are often spinal or cerebellar in origin. Ganglionic movement disorders are much more common in PPMS compared to our previously-studied group of RRMS patients.
Disclosure: Dr. Abboud is a consultant for Biogen and Genentech. Ms. Woodson is a speaker for Genentech and Biogen. Dr. Serra is a consultant for Biogen.