Abstract: P370
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS and gender
Introduction: Multiple sclerosis (MS) commonly affects young women of childbearing age who also frequently face issues related to becoming pregnant. There are some myths and doubts about pregnancy, newborns and progression of MS, causing many patients to fear becoming pregnant.
Objective: To study the pregnancy and obstetrical outcomes of RRMS patients in a prospective spanish cohort
Methods: Observational study. We followed-up prospectively those MS patients who wanted to become pregnant, their pregnancies and twelve months post-partum for four years. We collected information about concomitant diseases, contraceptive methods, artificial reproductive techniques (ART), DMTs, anaesthesia, kind of delivery and outcomes of the newborns. We compared these data with data of the Spanish population.
Results: From a cohort of 1166 patients, 60 pregnant (patients?) with 76 pregnancies were followed in the last 4 years. The Mean age was 35 ( 25-43) , mean BMI 20, mean disease duration 75 months, 65% were treated with DMTs before pregnancy. 22% were smokers and 15% moderate alcohol consumers. 17% received ARTs. 20% (verb: e.g. had/experienced) spontaneous abortion in the first trimester and 9% (verb: e.g. had/developed gestational diabetes. Mean duration of pregnancy was 39 + 1,7 weeks. C-sections was performed in 23% of the patients. 18% of patients didn´t receive anaesthesia during vaginal birth. All pregnancies resulted in live births, with no complications. Only 2% of malformations in newborns were reported. The mean birthweight was 3120 gr. Newborns of patients with moderate alcohol consumptionbefore the pregnancy has a trend of less weight at birth (300mg less). When we compare these data with the national and obstetrical spanish register there were no significant differences.
Conclusions: MS patients have very similar pregnancy and obstetrical outcomes as the generalSpanish population. Newborns have similar outcomes as the newborns of the spanish population register, In conclusion there are no obstetrical or neurological reasons to avoid pregnancy in MS patients
Disclosure: Celia Oreja-Guevara received honoraria as speaker from Biogen-Idec, Roche, Merck-Serono, Teva, Genzyme and Novartis.
Marina Alonso-Sepulveda:nothing to disclose
Miguel Kawiorski:nothing to disclose
Monica Luque Alarcon: nothing to disclose
Pilar Lafuente-González:Speaking and/or consultancy honoraria from Biogen and Sanofi,
Abstract: P370
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS and gender
Introduction: Multiple sclerosis (MS) commonly affects young women of childbearing age who also frequently face issues related to becoming pregnant. There are some myths and doubts about pregnancy, newborns and progression of MS, causing many patients to fear becoming pregnant.
Objective: To study the pregnancy and obstetrical outcomes of RRMS patients in a prospective spanish cohort
Methods: Observational study. We followed-up prospectively those MS patients who wanted to become pregnant, their pregnancies and twelve months post-partum for four years. We collected information about concomitant diseases, contraceptive methods, artificial reproductive techniques (ART), DMTs, anaesthesia, kind of delivery and outcomes of the newborns. We compared these data with data of the Spanish population.
Results: From a cohort of 1166 patients, 60 pregnant (patients?) with 76 pregnancies were followed in the last 4 years. The Mean age was 35 ( 25-43) , mean BMI 20, mean disease duration 75 months, 65% were treated with DMTs before pregnancy. 22% were smokers and 15% moderate alcohol consumers. 17% received ARTs. 20% (verb: e.g. had/experienced) spontaneous abortion in the first trimester and 9% (verb: e.g. had/developed gestational diabetes. Mean duration of pregnancy was 39 + 1,7 weeks. C-sections was performed in 23% of the patients. 18% of patients didn´t receive anaesthesia during vaginal birth. All pregnancies resulted in live births, with no complications. Only 2% of malformations in newborns were reported. The mean birthweight was 3120 gr. Newborns of patients with moderate alcohol consumptionbefore the pregnancy has a trend of less weight at birth (300mg less). When we compare these data with the national and obstetrical spanish register there were no significant differences.
Conclusions: MS patients have very similar pregnancy and obstetrical outcomes as the generalSpanish population. Newborns have similar outcomes as the newborns of the spanish population register, In conclusion there are no obstetrical or neurological reasons to avoid pregnancy in MS patients
Disclosure: Celia Oreja-Guevara received honoraria as speaker from Biogen-Idec, Roche, Merck-Serono, Teva, Genzyme and Novartis.
Marina Alonso-Sepulveda:nothing to disclose
Miguel Kawiorski:nothing to disclose
Monica Luque Alarcon: nothing to disclose
Pilar Lafuente-González:Speaking and/or consultancy honoraria from Biogen and Sanofi,