Contributions
Abstract: P361
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Given the role of both environmental and genetic factors in the aetiology of MS, quantifying the local prevalence of this condition in geographically distinct regions is important to understand its true burden, especially across diverse racial/ethnic populations residing in the same region and with access to the same healthcare.
Aims: To quantify the prevalence of MS in a healthcare delivery system in Northern California, USA.
Methods: We used an electronic health records database from a healthcare delivery system in Northern California, USA to quantify the prevalence of MS in adults ≥18 years of age. Individuals who had an International Classification of Disease 9/10 diagnosis of MS between 2010 and 2016 were identified. Overall and annual prevalence rates were calculated based on the total number of patient encounters during the entire study period and during each year, respectively. Rates were expressed per 100,000 of the population with 95% confidence intervals (CI). For comparisons by year, gender, and racial/ethnic groups, rates were age-adjusted using logistic regression.
Results: Among 1,508,102 adult patients in the Northern California healthcare system between 2010 and 2016, MS prevalence was 311 (95% CI: 300 to 321) per 100,000 population. There was a significant increase in age-adjusted prevalence from 259 (95% CI: 249 to 271) per 100,000 in 2010 to 358 (95% CI: 344 to 372) per 100,000 in 2016 (P< 0.0001). A 2.3-fold higher age-adjusted MS prevalence was observed for women compared with men (385 and 164 per 100,000, respectively; P< 0.0001). The highest age-adjusted MS prevalence was found among black women (677 per 100,000), whereas Asian men had the lowest prevalence (50 per 100,000). The age-adjusted prevalence of MS showed a numerical increase from 2010 to 2016 across all gender and racial/ethnic subgroups; however, only non-Hispanic white women, the largest subgroup, showed a significant linear increase in prevalence by year (27 additional cases per 100,000 population per year; P< 0.0001).
Conclusion: In a healthcare practice-based setting in Northern California, the prevalence of MS differed by gender and race/ethnicity, and was highest among black women. This study suggests that the prevalence of MS in the US is increasing, most notably among non-Hispanic white women.
Disclosure: RJR: Research funding (Janssen, Regeneron, and Sanofi); QH: Nothing to disclose; JL: Speaker (EMD Serono, and Sanofi); AW, LH, and AS: Employees of Sanofi. STUDY SUPPORT: Sanofi.
Abstract: P361
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Epidemiology
Introduction: Given the role of both environmental and genetic factors in the aetiology of MS, quantifying the local prevalence of this condition in geographically distinct regions is important to understand its true burden, especially across diverse racial/ethnic populations residing in the same region and with access to the same healthcare.
Aims: To quantify the prevalence of MS in a healthcare delivery system in Northern California, USA.
Methods: We used an electronic health records database from a healthcare delivery system in Northern California, USA to quantify the prevalence of MS in adults ≥18 years of age. Individuals who had an International Classification of Disease 9/10 diagnosis of MS between 2010 and 2016 were identified. Overall and annual prevalence rates were calculated based on the total number of patient encounters during the entire study period and during each year, respectively. Rates were expressed per 100,000 of the population with 95% confidence intervals (CI). For comparisons by year, gender, and racial/ethnic groups, rates were age-adjusted using logistic regression.
Results: Among 1,508,102 adult patients in the Northern California healthcare system between 2010 and 2016, MS prevalence was 311 (95% CI: 300 to 321) per 100,000 population. There was a significant increase in age-adjusted prevalence from 259 (95% CI: 249 to 271) per 100,000 in 2010 to 358 (95% CI: 344 to 372) per 100,000 in 2016 (P< 0.0001). A 2.3-fold higher age-adjusted MS prevalence was observed for women compared with men (385 and 164 per 100,000, respectively; P< 0.0001). The highest age-adjusted MS prevalence was found among black women (677 per 100,000), whereas Asian men had the lowest prevalence (50 per 100,000). The age-adjusted prevalence of MS showed a numerical increase from 2010 to 2016 across all gender and racial/ethnic subgroups; however, only non-Hispanic white women, the largest subgroup, showed a significant linear increase in prevalence by year (27 additional cases per 100,000 population per year; P< 0.0001).
Conclusion: In a healthcare practice-based setting in Northern California, the prevalence of MS differed by gender and race/ethnicity, and was highest among black women. This study suggests that the prevalence of MS in the US is increasing, most notably among non-Hispanic white women.
Disclosure: RJR: Research funding (Janssen, Regeneron, and Sanofi); QH: Nothing to disclose; JL: Speaker (EMD Serono, and Sanofi); AW, LH, and AS: Employees of Sanofi. STUDY SUPPORT: Sanofi.