Contributions
Abstract: P344
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system that causes lesions in the optic nerve, spinal cord and brain.Literature data shows an ever-growing list of autoimmune diseases associated with NMOSD.
Aims: The aim of this study was to identify and compare the basic and clinical features of NMOSD patients with and without concomitant autoimmune diseases.
Methods: We conducted a case-control study among patients with a definite diagnosis of NMOSD, referred to Sina hospital, a tertiary care referral center in Tehran, from April 1, 2015 to April 1, 2016. Seventy nine NMOSD patients, both with concomitant autoimmune diseases (n = 18, case group) and without concomitant autoimmune diseases (n = 61, control group) were enrolled. The demographic data consist of gender, current age, NMOSD onset age, disease duration, family history of MS and NMOSD, smoking habit, passive smoker, and also clinical and laboratory data including Expanded Disability Status Scale (EDSS),Annual Relapse Rate (ARR) and positivity or negativity of NMO-IgG were collected. Data were processed using the Independent t-test and the Logistic regression was applied to evaluate association among variables.
Results: The female to male ratio was 8:1 in case group and 4.54:1 in control group. Our results revealed a significant relationship between case and control groups in NMOSD onset age (37.50±9.84 vs 30.72±10.87, P value = 0.02, 95%CI = 1.08-12.47). We found no significant differences in other characteristic variables between case and control groups. NMO-IgG positivity was 52.9% and 53.4% in case and control group respectively. The mean EDSS was 3.27±1.89 in case group and 2.89±2.11 in control group but this difference was not statically significant (P value˃0.05), even after adjusting for gender, age and disease duration. The mean ARR was calculated 1.18±0.88 in cases and 0.87±0.71 in controls (P value˃0.05).
Conclusions: Basic and clinical studies of the NMOSD associated with autoimmune diseases are limited and there is no consensus about that. Results of our study demonstrate that several autoimmune diseases may co-exist with NMOSD and this co-existence may enhance the NMOSD onset age and may also worsen the disease course. Further studies are needed to investigate the effect of concomitant autoimmune diseases on the course of NMOSD.
Disclosure: Negar Molazadeh: nothing to disclose
Sharareh Eskandarieh: nothing to disclose
Abdorreza Naser Moghadasi: nothing to disclose
Raziyeh Sadat Kazemi: nothing to disclose
Mohammad Ali Sahraian: nothing to disclose
Abstract: P344
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - MS Variants
Introduction: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system that causes lesions in the optic nerve, spinal cord and brain.Literature data shows an ever-growing list of autoimmune diseases associated with NMOSD.
Aims: The aim of this study was to identify and compare the basic and clinical features of NMOSD patients with and without concomitant autoimmune diseases.
Methods: We conducted a case-control study among patients with a definite diagnosis of NMOSD, referred to Sina hospital, a tertiary care referral center in Tehran, from April 1, 2015 to April 1, 2016. Seventy nine NMOSD patients, both with concomitant autoimmune diseases (n = 18, case group) and without concomitant autoimmune diseases (n = 61, control group) were enrolled. The demographic data consist of gender, current age, NMOSD onset age, disease duration, family history of MS and NMOSD, smoking habit, passive smoker, and also clinical and laboratory data including Expanded Disability Status Scale (EDSS),Annual Relapse Rate (ARR) and positivity or negativity of NMO-IgG were collected. Data were processed using the Independent t-test and the Logistic regression was applied to evaluate association among variables.
Results: The female to male ratio was 8:1 in case group and 4.54:1 in control group. Our results revealed a significant relationship between case and control groups in NMOSD onset age (37.50±9.84 vs 30.72±10.87, P value = 0.02, 95%CI = 1.08-12.47). We found no significant differences in other characteristic variables between case and control groups. NMO-IgG positivity was 52.9% and 53.4% in case and control group respectively. The mean EDSS was 3.27±1.89 in case group and 2.89±2.11 in control group but this difference was not statically significant (P value˃0.05), even after adjusting for gender, age and disease duration. The mean ARR was calculated 1.18±0.88 in cases and 0.87±0.71 in controls (P value˃0.05).
Conclusions: Basic and clinical studies of the NMOSD associated with autoimmune diseases are limited and there is no consensus about that. Results of our study demonstrate that several autoimmune diseases may co-exist with NMOSD and this co-existence may enhance the NMOSD onset age and may also worsen the disease course. Further studies are needed to investigate the effect of concomitant autoimmune diseases on the course of NMOSD.
Disclosure: Negar Molazadeh: nothing to disclose
Sharareh Eskandarieh: nothing to disclose
Abdorreza Naser Moghadasi: nothing to disclose
Raziyeh Sadat Kazemi: nothing to disclose
Mohammad Ali Sahraian: nothing to disclose