Contributions
Abstract: P339
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: Multiple Sclerosis (MS) diagnosis remains a challenge because of the heterogeneity of the clinical presentation and the interindividual evolutivity among patients. Throughout the years, scientific and technological progress in multiple fields such as imaging, biology and pathology contributed to better define MS diagnosis. In 2017, new elements were added to the previous MS definition, the 2017 McDonald criteria.
Objective: To evaluate the impact of the 2017 McDonald criteria on MS diagnosis delay and on direct medical costs by studying a hundred recurrent-remitting MS patients.
Methods: We analysed the last hundred patients included in the European Database for Multiple Sclerosis (EDMUS) cohort by our Neurology department at the University Hospital of Rouen (France). Demographic (sex, age), clinical (Expanded Disability Status Scale - EDSS), imaging (lesion load on brain Magnetic Resonance Imaging - MRI), biology (oligoclonal bands in the Cerebrospinal Fluid - CSF) and economical variables were evaluated.
Results: Application of the 2017 McDonald criteria were associated with a mean decrease of MS diagnosis delay of 28.58 weeks eg. about 7 months (p=0,0002 ; CI 95%=[16,1 ; 40,3 weeks]) among 12 patients. All of these patients had received a lumbar puncture and had positive oligoclonal bands in the CSF. 2 of them had symptomatic lesions and 2 had cortical lesions on the MRI. The mean EDSS score was 1,38 [0 ; 5] . In comparison, among the patients whom MS diagnosis was not shortened by the 2017 McDonald criteria, 30 patients had a lumbar puncture, among which 16 (53%) had positive oligoclonal bands. 23 of these patients had symptomatic lesions and 2 had cortical lesions on the MRI. The mean direct medical costs during the delayed diagnosis period is under calculation. Further data will be presented at the ECTRIMS.
Conclusion: Applying the 2017 McDonald criteria can reduce diagnosis delay when oligoclonal bands are positive in the CSF and can contribute in treating MS patients earlier than with the previous Revised 2010 criteria.
Disclosure: Nothing to disclose
Abstract: P339
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Background: Multiple Sclerosis (MS) diagnosis remains a challenge because of the heterogeneity of the clinical presentation and the interindividual evolutivity among patients. Throughout the years, scientific and technological progress in multiple fields such as imaging, biology and pathology contributed to better define MS diagnosis. In 2017, new elements were added to the previous MS definition, the 2017 McDonald criteria.
Objective: To evaluate the impact of the 2017 McDonald criteria on MS diagnosis delay and on direct medical costs by studying a hundred recurrent-remitting MS patients.
Methods: We analysed the last hundred patients included in the European Database for Multiple Sclerosis (EDMUS) cohort by our Neurology department at the University Hospital of Rouen (France). Demographic (sex, age), clinical (Expanded Disability Status Scale - EDSS), imaging (lesion load on brain Magnetic Resonance Imaging - MRI), biology (oligoclonal bands in the Cerebrospinal Fluid - CSF) and economical variables were evaluated.
Results: Application of the 2017 McDonald criteria were associated with a mean decrease of MS diagnosis delay of 28.58 weeks eg. about 7 months (p=0,0002 ; CI 95%=[16,1 ; 40,3 weeks]) among 12 patients. All of these patients had received a lumbar puncture and had positive oligoclonal bands in the CSF. 2 of them had symptomatic lesions and 2 had cortical lesions on the MRI. The mean EDSS score was 1,38 [0 ; 5] . In comparison, among the patients whom MS diagnosis was not shortened by the 2017 McDonald criteria, 30 patients had a lumbar puncture, among which 16 (53%) had positive oligoclonal bands. 23 of these patients had symptomatic lesions and 2 had cortical lesions on the MRI. The mean direct medical costs during the delayed diagnosis period is under calculation. Further data will be presented at the ECTRIMS.
Conclusion: Applying the 2017 McDonald criteria can reduce diagnosis delay when oligoclonal bands are positive in the CSF and can contribute in treating MS patients earlier than with the previous Revised 2010 criteria.
Disclosure: Nothing to disclose