Contributions
Abstract: P333
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Development of the Mac Donald criteria (MDc) for Multiple sclerosis (MS) diagnosis and subsequent revisions were based on data from adult white European and North American populations. In North Africans (NAs), prevalence, clinical phenotype and differential diagnosis of MS are different. In 2017, the International Panel on Diagnosis of MS reviewed the 2010 criteria and recommended revisions. However, their relevance in NAs remains discussed. Data about the reliability of MS criteria in our region are scarce.
To study the sensitivity of 2017 MDc in a cohort of Tunisian patients with typical clinical isolated syndrome (CIS).
From 2003 to 2017, we collected patients with typical CIS followed in the department of Neurology of Razi Hospital. They had clinical follow-up of at least two years or until the development of definite MS. All patients were aged of 18 to 50 years and had baseline MRI obtained within three months of onset.
Seventy patients met inclusion criteria and consisted of 54 women and 16 men. Mean age was 36.6 ± 11.2 years with mean age when CIS occurred around 29.6 ±9.7 years. CIS was monofocal in 80.6%. It included spinal cord symptoms (40%), optic neuritis (32%), brainstem or cerebellar symptoms (18%) and supratentorial syndrome (10%). Only one patient remained diagnosed as CIS. At first attack, 2010 MDc were fulfilled in 38.5% while 64.4% with 2017 MDc thanks to CSF analysis in 11.4% and inclusion of symptomatic and asymptomatic lesions in 14.5%. The 2017 criteria had higher sensitivity compared to 2010 version in our population (74% versus 44.4%).
In our NA cohort, new criteria allowed the diagnosis of a higher rate of MS since first clinical event. More studies are urgently needed to really validate these criteria in our latitudes.
Disclosure: Souissi A: nothing to disclose
Mrabet S: nothing ti disclose
Nasri A: nothing to disclose
Laarnaout F: nothing to disclose
Kacem I: nothing to disclose
Gargouri A: nothing to disclose
Gouider R: nothing to disclose
Abstract: P333
Type: Poster Sessions
Abstract Category: Clinical aspects of MS - Diagnosis and differential diagnosis
Development of the Mac Donald criteria (MDc) for Multiple sclerosis (MS) diagnosis and subsequent revisions were based on data from adult white European and North American populations. In North Africans (NAs), prevalence, clinical phenotype and differential diagnosis of MS are different. In 2017, the International Panel on Diagnosis of MS reviewed the 2010 criteria and recommended revisions. However, their relevance in NAs remains discussed. Data about the reliability of MS criteria in our region are scarce.
To study the sensitivity of 2017 MDc in a cohort of Tunisian patients with typical clinical isolated syndrome (CIS).
From 2003 to 2017, we collected patients with typical CIS followed in the department of Neurology of Razi Hospital. They had clinical follow-up of at least two years or until the development of definite MS. All patients were aged of 18 to 50 years and had baseline MRI obtained within three months of onset.
Seventy patients met inclusion criteria and consisted of 54 women and 16 men. Mean age was 36.6 ± 11.2 years with mean age when CIS occurred around 29.6 ±9.7 years. CIS was monofocal in 80.6%. It included spinal cord symptoms (40%), optic neuritis (32%), brainstem or cerebellar symptoms (18%) and supratentorial syndrome (10%). Only one patient remained diagnosed as CIS. At first attack, 2010 MDc were fulfilled in 38.5% while 64.4% with 2017 MDc thanks to CSF analysis in 11.4% and inclusion of symptomatic and asymptomatic lesions in 14.5%. The 2017 criteria had higher sensitivity compared to 2010 version in our population (74% versus 44.4%).
In our NA cohort, new criteria allowed the diagnosis of a higher rate of MS since first clinical event. More studies are urgently needed to really validate these criteria in our latitudes.
Disclosure: Souissi A: nothing to disclose
Mrabet S: nothing ti disclose
Nasri A: nothing to disclose
Laarnaout F: nothing to disclose
Kacem I: nothing to disclose
Gargouri A: nothing to disclose
Gouider R: nothing to disclose