Contributions
Abstract: 111
Type: Oral
Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS. Recent rediscoveries of lymphatic vessels within the dura mater surrounding the brain, made possible by modern live-cell imaging technologies, have revived this discussion. Understanding the immune privilege of the CNS requires intimate knowledge of its unique anatomy. The presentation will highlight how endothelial and epithelial brain barriers establish compartments in the CNS that differ strikingly with respect to their accessibility to immune-cell subsets. This will include explanation of our present knowledge on the cellular and molecular mechanisms involved in immune-cell trafficking across these barriers
Disclosure: I have no disclosures
Abstract: 111
Type: Oral
Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS. Recent rediscoveries of lymphatic vessels within the dura mater surrounding the brain, made possible by modern live-cell imaging technologies, have revived this discussion. Understanding the immune privilege of the CNS requires intimate knowledge of its unique anatomy. The presentation will highlight how endothelial and epithelial brain barriers establish compartments in the CNS that differ strikingly with respect to their accessibility to immune-cell subsets. This will include explanation of our present knowledge on the cellular and molecular mechanisms involved in immune-cell trafficking across these barriers
Disclosure: I have no disclosures