Contributions
Abstract: 73
Type: Oral
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Background: Diagnostic criteria were published by the European Susac Syndrome Consortium (EuSaC) for Susac Syndrome (SuS), an autoimmune endotheliopathy. While the authors suggest the criteria do diagnose reported cases with good sensitivity, their method of case review did not evaluate diagnosis at first presentation. Classification criteria for Susac Syndrome that recognize early and limited forms of disease will enhance both clinical care and facilitate research and are proposed by the North American Susac Syndrome Collaboration.
Objectives: Compare performance of EuSaC diagnostic criteria and proposed classification criteria in early SuS.
Methods: Apply both EuSaC diagnostis criteria and NASSC classification criteria to 100 recently reported cases from the literature.
Results: There was discrepancy between the criteria in 74/100 cases. The EuSaC criteria diagnosed 45 cases at first evaluation. The results included 11 definite and 34 probable cases, with 55 not meeting diagnostic criteria. The NASSC criteria were able to classify 97/100 cases. 32 cases were classified at definite levels, 47 as probable. The NASSC classification criteria also include levels of possible and potential, which accounted for 1 and 16 cases respectively. At final diagnosis, only 14 cases did not meet EuSaC diagnostic criteria and all were classified in NASSC criteria.
Conclusion: The proposed NASSC Classification Criteria provides labels for the heterogeneity of reported cases of SuS, including the presence/absence of the complete triad and callosal lesions and EuSaC Diagnostic Criteria.
Disclosure:
Gillian Paton: Nothing to disclose
Mollie Carruthers: Nothing to disclose
Claire Sheldon: Nothing to disclose
Talia Vertinsky: Nothing to disclose
Anthony Traboulsee: Nothing to disclose
Robert Rennebohm: Nothing to disclose
Robert Carruthers: Nothing to disclose
Abstract: 73
Type: Oral
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Background: Diagnostic criteria were published by the European Susac Syndrome Consortium (EuSaC) for Susac Syndrome (SuS), an autoimmune endotheliopathy. While the authors suggest the criteria do diagnose reported cases with good sensitivity, their method of case review did not evaluate diagnosis at first presentation. Classification criteria for Susac Syndrome that recognize early and limited forms of disease will enhance both clinical care and facilitate research and are proposed by the North American Susac Syndrome Collaboration.
Objectives: Compare performance of EuSaC diagnostic criteria and proposed classification criteria in early SuS.
Methods: Apply both EuSaC diagnostis criteria and NASSC classification criteria to 100 recently reported cases from the literature.
Results: There was discrepancy between the criteria in 74/100 cases. The EuSaC criteria diagnosed 45 cases at first evaluation. The results included 11 definite and 34 probable cases, with 55 not meeting diagnostic criteria. The NASSC criteria were able to classify 97/100 cases. 32 cases were classified at definite levels, 47 as probable. The NASSC classification criteria also include levels of possible and potential, which accounted for 1 and 16 cases respectively. At final diagnosis, only 14 cases did not meet EuSaC diagnostic criteria and all were classified in NASSC criteria.
Conclusion: The proposed NASSC Classification Criteria provides labels for the heterogeneity of reported cases of SuS, including the presence/absence of the complete triad and callosal lesions and EuSaC Diagnostic Criteria.
Disclosure:
Gillian Paton: Nothing to disclose
Mollie Carruthers: Nothing to disclose
Claire Sheldon: Nothing to disclose
Talia Vertinsky: Nothing to disclose
Anthony Traboulsee: Nothing to disclose
Robert Rennebohm: Nothing to disclose
Robert Carruthers: Nothing to disclose