Contributions
Abstract: P1103
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Objective: Patients with multiple sclerosis (MS) often have unrecognized sleep disorders, that may contribute to fatigue and impact on quality of life (QoL). However, the exact relationship between sleep quality, fatigue and cognitive function is today poorly understood. Our purpose was to compare the neuropsychological profile of newly diagnosed MS subjects with and without sleep complains.
Materials and methods: we enrolled 85 subjects satisfying 2010 revised McDonald criteria from June 2012 to January 2017 at our MS Center. At a mean time of 5.3 months from diagnosis, each patient underwent a multidimensional assessment comprehensive of neuropsychological tests (BRB, MMSE, Clock Drawing, Verbal Fluency, Digit Span, Corsi, EBN, Rivermead Behavioural Memory, TMA, TMB, Stroop, Attentive Matrices, Raven's Progressive Matrices, Tower of London, Rey Complex Figure Test, WCST), evaluation of depression, anxiety, sleep, fatigue and QoL (BDI, STAI-Y, PSQI, ESS, FSS, MSQOL-54), motor function and disability (9HPT, TWT, EDSS). Subjects were classified as good (MS-SL+) or bad (MS-SL-) sleepers respectively by a PSQI score > or ≤ 5.
Results: 36% of our patients (n=30) were MS-SL-. No significant difference in sex prevalence (Males: 21.2% MS-SL+, 36.7% MS-SL-) or mean age (median MS-SL+: 35; MS-SL-: 39 years old) was detected. MS-SL+ had higher education (13.8±3.2 vs 11.5±3.4 years,p< 0.005) and less disability at diagnosis than MS-SL-(median EDSS: 1.5 vs 2.0,p< 0.005). Cognitive scores were all suprathreshold and comparable, except for MMSE (median: 30 vs 29, p< 0.05),SRT-LTS (mean score: 47.8±13.3 vs 40.9±14.9, p< 0.05), Rey Figure copy (median: 34 vs 32, p< 0.05) which were better in MS-SL+. No differences were detected on daytime sleepiness. MS-SL- subjects had higher scores on anxious-depressive symptoms (median BDI: 15 vs 5, p< 0.005; median STAY: 51 vs 37, p< 0.005), accentuated fatigue (FSS median: 4.5 vs 2.6,p< 0.005), poorer QoL (MSQOL-54 physical median: 49.6 vs 77.5, mental median: 51.8 vs 77.2,p< 0.005) and motor skills (9-HPT median: 19.1 vs 17.7,p< 0.05) than MS-SL+ subjects.
Discussion and conclusions: In line with others studies, our investigation confirms a relationship between sleep complains, cognitive functioning, emotional status, fatigue and QoL. In contrast with current literature, we didn't find any influence of daytime sleepiness on sleep disorders and fatigue. Further longitudinal observations and a larger sample are needed to validate our results.
Disclosure: Marta Zaffira Conti: nothing to disclose
Paola Previtali: nothing to disclose
Sara La Gioia: nothing to disclose
Valeria Barcella: nothing to disclose
Barbara Frigeni: nothing to disclose
Clara Zanchi: nothing to disclose
Marcella Vedovello: nothing to disclose
Simonetta Spada: nothing to disclose
Mariarosa Rottoli: nothing to disclose
Abstract: P1103
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Objective: Patients with multiple sclerosis (MS) often have unrecognized sleep disorders, that may contribute to fatigue and impact on quality of life (QoL). However, the exact relationship between sleep quality, fatigue and cognitive function is today poorly understood. Our purpose was to compare the neuropsychological profile of newly diagnosed MS subjects with and without sleep complains.
Materials and methods: we enrolled 85 subjects satisfying 2010 revised McDonald criteria from June 2012 to January 2017 at our MS Center. At a mean time of 5.3 months from diagnosis, each patient underwent a multidimensional assessment comprehensive of neuropsychological tests (BRB, MMSE, Clock Drawing, Verbal Fluency, Digit Span, Corsi, EBN, Rivermead Behavioural Memory, TMA, TMB, Stroop, Attentive Matrices, Raven's Progressive Matrices, Tower of London, Rey Complex Figure Test, WCST), evaluation of depression, anxiety, sleep, fatigue and QoL (BDI, STAI-Y, PSQI, ESS, FSS, MSQOL-54), motor function and disability (9HPT, TWT, EDSS). Subjects were classified as good (MS-SL+) or bad (MS-SL-) sleepers respectively by a PSQI score > or ≤ 5.
Results: 36% of our patients (n=30) were MS-SL-. No significant difference in sex prevalence (Males: 21.2% MS-SL+, 36.7% MS-SL-) or mean age (median MS-SL+: 35; MS-SL-: 39 years old) was detected. MS-SL+ had higher education (13.8±3.2 vs 11.5±3.4 years,p< 0.005) and less disability at diagnosis than MS-SL-(median EDSS: 1.5 vs 2.0,p< 0.005). Cognitive scores were all suprathreshold and comparable, except for MMSE (median: 30 vs 29, p< 0.05),SRT-LTS (mean score: 47.8±13.3 vs 40.9±14.9, p< 0.05), Rey Figure copy (median: 34 vs 32, p< 0.05) which were better in MS-SL+. No differences were detected on daytime sleepiness. MS-SL- subjects had higher scores on anxious-depressive symptoms (median BDI: 15 vs 5, p< 0.005; median STAY: 51 vs 37, p< 0.005), accentuated fatigue (FSS median: 4.5 vs 2.6,p< 0.005), poorer QoL (MSQOL-54 physical median: 49.6 vs 77.5, mental median: 51.8 vs 77.2,p< 0.005) and motor skills (9-HPT median: 19.1 vs 17.7,p< 0.05) than MS-SL+ subjects.
Discussion and conclusions: In line with others studies, our investigation confirms a relationship between sleep complains, cognitive functioning, emotional status, fatigue and QoL. In contrast with current literature, we didn't find any influence of daytime sleepiness on sleep disorders and fatigue. Further longitudinal observations and a larger sample are needed to validate our results.
Disclosure: Marta Zaffira Conti: nothing to disclose
Paola Previtali: nothing to disclose
Sara La Gioia: nothing to disclose
Valeria Barcella: nothing to disclose
Barbara Frigeni: nothing to disclose
Clara Zanchi: nothing to disclose
Marcella Vedovello: nothing to disclose
Simonetta Spada: nothing to disclose
Mariarosa Rottoli: nothing to disclose