Contributions
Abstract: P1100
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: Cognitive impairment (CI) is common in multiple sclerosis (MS). Few patients complain about cognitive difficulties in early stages. The structural correlates of CI are still controversial.
Method: We compared 69 MS patients with definite CI according to detailed neuropsychological evaluation (NPE) with 612 MS patients without CI according to the screening test MUSIC (MS Inventory Cognition) by three-dimensional T1-weighted and FLAIR scans at 3 Tesla. Factor analysis was performed to reduce the number of NPE subtests. We determined volumes of cortical grey matter (GM), white matter (WM), thalamus, putamen, caudate nucleus, hippocampus, amygdala, nucleus accumbens and WM lesion volume (WML). The relationship between neuropsychological findings and brain volumes was examined by general linear models.
Results: By factor analysis, we identified four factors in the CI group and chose the most representative subtest of each factor for further analysis (free recall, reaction time without tone, verbal memory span, trail making test A). Yet we were unable to demonstrate differential relationships of neuropsychological subtests with MRI-based volumes. Comparing MS patients with CI to those without CI, we found higher WML (p< 0.001) and decreased GM volumes (all ps< 0.03). After correction for EDSS and multiple testing, however, only thalamic atrophy and WML remained significant (p< 0.001). In models including both WML and thalamic volume, only WML explained CI independently.
Conclusion: Although we could confirm the relation of thalamic atrophy with CI, we observed the most robust association of CI with WML.
Disclosure:
Christina Engl received research grant from „Kommission für Klinische Forschung (KKF, Committee for clinical research ) of the Technical University Munich.
Muna-Miriam Hoshi received travel grant from Bayer Health Care for participation in annual Meeting of German Neurologic Society 2016.
Jan Kirschke has received research funding from the European Research Council and the German Research Foundation, travel support from Kaneka Europe as well as speaker honoraria from Philips Healthcare; all not related to this work.
Bernhard Hemmer has served on scientific advisory boards for F. Hoffmann-La Roche Ltd, Novartis, Bayer AG, and Genentech; he has served as DMSC member for AllergyCare; he or his institution have received speaker honoraria from Biogen Idec, Teva Neuroscience, Merck Serono, Medimmune, Novartis, Desitin, and F. Hoffmann-La Roche Ltd; his institution has received research support from Chugai Pharmaceuticals and Hoffmann-La-Roche; holds part of two patents; one for the detection of antibodies and T cells against KIR4.1 in a subpopulation of MS patients and one for genetic determinants of neutralizing antibodies to interferon β.
Mark Mühlau received research support from Merck Serono and Novartis.
Laura Bok: nothing to disclose. Sophia Grahl: nothing to disclose. Paul Schmidt: nothing to disclose. Viola Biberacher: nothing to disclose. Annkathrin Beer: nothing to disclose.
Abstract: P1100
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: Cognitive impairment (CI) is common in multiple sclerosis (MS). Few patients complain about cognitive difficulties in early stages. The structural correlates of CI are still controversial.
Method: We compared 69 MS patients with definite CI according to detailed neuropsychological evaluation (NPE) with 612 MS patients without CI according to the screening test MUSIC (MS Inventory Cognition) by three-dimensional T1-weighted and FLAIR scans at 3 Tesla. Factor analysis was performed to reduce the number of NPE subtests. We determined volumes of cortical grey matter (GM), white matter (WM), thalamus, putamen, caudate nucleus, hippocampus, amygdala, nucleus accumbens and WM lesion volume (WML). The relationship between neuropsychological findings and brain volumes was examined by general linear models.
Results: By factor analysis, we identified four factors in the CI group and chose the most representative subtest of each factor for further analysis (free recall, reaction time without tone, verbal memory span, trail making test A). Yet we were unable to demonstrate differential relationships of neuropsychological subtests with MRI-based volumes. Comparing MS patients with CI to those without CI, we found higher WML (p< 0.001) and decreased GM volumes (all ps< 0.03). After correction for EDSS and multiple testing, however, only thalamic atrophy and WML remained significant (p< 0.001). In models including both WML and thalamic volume, only WML explained CI independently.
Conclusion: Although we could confirm the relation of thalamic atrophy with CI, we observed the most robust association of CI with WML.
Disclosure:
Christina Engl received research grant from „Kommission für Klinische Forschung (KKF, Committee for clinical research ) of the Technical University Munich.
Muna-Miriam Hoshi received travel grant from Bayer Health Care for participation in annual Meeting of German Neurologic Society 2016.
Jan Kirschke has received research funding from the European Research Council and the German Research Foundation, travel support from Kaneka Europe as well as speaker honoraria from Philips Healthcare; all not related to this work.
Bernhard Hemmer has served on scientific advisory boards for F. Hoffmann-La Roche Ltd, Novartis, Bayer AG, and Genentech; he has served as DMSC member for AllergyCare; he or his institution have received speaker honoraria from Biogen Idec, Teva Neuroscience, Merck Serono, Medimmune, Novartis, Desitin, and F. Hoffmann-La Roche Ltd; his institution has received research support from Chugai Pharmaceuticals and Hoffmann-La-Roche; holds part of two patents; one for the detection of antibodies and T cells against KIR4.1 in a subpopulation of MS patients and one for genetic determinants of neutralizing antibodies to interferon β.
Mark Mühlau received research support from Merck Serono and Novartis.
Laura Bok: nothing to disclose. Sophia Grahl: nothing to disclose. Paul Schmidt: nothing to disclose. Viola Biberacher: nothing to disclose. Annkathrin Beer: nothing to disclose.