Contributions
Abstract: P1088
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Background: Optical Coherence Tomography (OCT) is a non-invasive modality used to quantify the thickness of the retinal nerve fiber layer (RNFL). In adult multiple sclerosis (MS) patients, RNFL thickness correlates with degree of impairment on neurocognitive measures. This has not been examined in pediatric MS patients.
Objective: To determine if RNFL thickness correlates with performance on neuropsychological measures in pediatric MS patients.
Methods: Data was collected via retrospective chart review of all 120 patients with MS at Texas Children's Hospital. 32 patients had OCT and MS clinic visit (where Expanded Disability Status Scale or EDSS was calculated) within 12 months of each other. 20 of these patients underwent neuropsychological evaluations and OCT with mean time between the two of 8.1 months. 5 of the 20 patients had a history of Optic Neuritis (ON).
The WISC-V/WAIS-V Processing Speed Index and the Oral Symbol Digit Modality Test assessed processing speed with or without a fine motor component. The Grooved Pegboard Test assessed fine motor speed. Correlation between average RNFL and processing speeds and fine motor standard scores was measured. Correlation between average RNFL and EDSS in all 32 patients was also measured.
Results: Thickness of the RNFL was positively correlated with fine motor speed and dexterity (r2= 0.46, p = 0.02). There was no significant correlation between RNFL and processing speed scores. Furthermore, there was no significant correlation between RNFL and EDSS.
Conclusion: The literature indicates that compromised fine motor skills are often the earliest sign of neurocognitive deficits in pediatric patients with demyelinating diseases. Our data showed a significant positive correlation between RNFL thickness and fine motor speed and dexterity, however did not show a significant correlation between RNFL thickness and EDSS or processing speed scores. This suggests that changes in RNFL may be indicative of early neurocognitive deficits that are perhaps too subtle to be captured by the EDSS or processing speed scores. Thus, our data supports early neuropsychological evaluation and consideration of possible interventions for patients with RNFL thinning on OCT.
Disclosure: Nikita Shukla: no disclosures
Karen Evankovich: no disclosures
Veeral Shah: no disclosures
Tim Lotze: no disclosures
Abstract: P1088
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Background: Optical Coherence Tomography (OCT) is a non-invasive modality used to quantify the thickness of the retinal nerve fiber layer (RNFL). In adult multiple sclerosis (MS) patients, RNFL thickness correlates with degree of impairment on neurocognitive measures. This has not been examined in pediatric MS patients.
Objective: To determine if RNFL thickness correlates with performance on neuropsychological measures in pediatric MS patients.
Methods: Data was collected via retrospective chart review of all 120 patients with MS at Texas Children's Hospital. 32 patients had OCT and MS clinic visit (where Expanded Disability Status Scale or EDSS was calculated) within 12 months of each other. 20 of these patients underwent neuropsychological evaluations and OCT with mean time between the two of 8.1 months. 5 of the 20 patients had a history of Optic Neuritis (ON).
The WISC-V/WAIS-V Processing Speed Index and the Oral Symbol Digit Modality Test assessed processing speed with or without a fine motor component. The Grooved Pegboard Test assessed fine motor speed. Correlation between average RNFL and processing speeds and fine motor standard scores was measured. Correlation between average RNFL and EDSS in all 32 patients was also measured.
Results: Thickness of the RNFL was positively correlated with fine motor speed and dexterity (r2= 0.46, p = 0.02). There was no significant correlation between RNFL and processing speed scores. Furthermore, there was no significant correlation between RNFL and EDSS.
Conclusion: The literature indicates that compromised fine motor skills are often the earliest sign of neurocognitive deficits in pediatric patients with demyelinating diseases. Our data showed a significant positive correlation between RNFL thickness and fine motor speed and dexterity, however did not show a significant correlation between RNFL thickness and EDSS or processing speed scores. This suggests that changes in RNFL may be indicative of early neurocognitive deficits that are perhaps too subtle to be captured by the EDSS or processing speed scores. Thus, our data supports early neuropsychological evaluation and consideration of possible interventions for patients with RNFL thinning on OCT.
Disclosure: Nikita Shukla: no disclosures
Karen Evankovich: no disclosures
Veeral Shah: no disclosures
Tim Lotze: no disclosures