Contributions
Abstract: P1083
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Objective: To explore potential relationships between VEP-L and OCT outcomes in People with Multiple Sclerosis (PwMS).
Background: Multiple Sclerosis (MS) is a disease with both demyelinating and axonal injury, but the degree/percent of each cannot be determined solely by EDSS and routine MRI metrics. Relapses and progressive disease in PwMS likely occur with varied types/degrees or combinations of such damage. Varied symptoms in PwMS likely represents a direct result of such complex damage. Objective proxy measures to evaluate the nature/type of disease impact/progression could help identify therapy efficacy, and perhaps provide a path towards treatment decisions. OCT objectifies axonal damage by measurement of retinal fiber density. VEP-L objectifies demyelinating burden along some of the visual pathway.
Methods: Retrospective cross sectional analysis of PwMS who completed both VEP and OCT testing prospectively. Linear regression modeling was used to analyze significant relationships between VEP-L (right eye, left eye, interocular latency difference) and OCT outcomes [retinal nerve fiber layer-global (RNFL-G) and nasal/temporal ratio (RNFL-N/T), Perimacular Bundle (PMB) and Macular Volume (MV)] for each eye and hemispheric asymmetry. Significance was set at p< 0.01.
Results: PwMS n=99, 76.8% female, average age 50.5±10.4 years. Significant associations (p< 0.01) were identified: VEP-L OD correlated with RNFL-G OU, PMB OU, and MV OU; VEP-L OS correlated with RNFL-G OU, PMB OU, MV OU, and with RNFL-N/T hemispheric asymmetry. VEP-L interocular latency difference correlated with both eyes and OCT hemispheric asymmetry for RNFL-G, PMB, and MV outcomes.
Conclusions: OCT measurements (RNFL-G, PMB, and MV) correlated better with VEP-L findings in PwMS than did RNFL-N/T regardless of which eye was investigated. VEP-L interocular latency difference was significantly correlated to hemispheric asymmetry in these same OCT outcomes. Proxy measurements of both myelin and axonal injury are relevant to evaluate the types/degrees of MS related damage and specific OCT measurements might reflect partial aspects of CNS damage in PwMS. Future studies investigating these proxy measures both cross sectionally and longitudinally should target RNFL-G, PMB, and MV outcomes rather than RNFL-N/T and how these relate to patient-centered metrics, biomarkers, prognosis and therapy efficacy.
Disclosure: This study was not supported by any outside funding.
Tabiri K: nothing to disclose
Srinivasan J: nothing to disclose
Wissemann K: nothing to disclose
Anand D: nothing to disclose
Fafard L: nothing to disclose
Bumstead B: nothing to disclose
Buhse M: nothing to disclose
Zarif M: nothing to disclose
Blitz K: nothing to disclose
Sergott R: is a consultant to Heidelberg Engineering
Gudesblatt M: nothing to disclose
Abstract: P1083
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Objective: To explore potential relationships between VEP-L and OCT outcomes in People with Multiple Sclerosis (PwMS).
Background: Multiple Sclerosis (MS) is a disease with both demyelinating and axonal injury, but the degree/percent of each cannot be determined solely by EDSS and routine MRI metrics. Relapses and progressive disease in PwMS likely occur with varied types/degrees or combinations of such damage. Varied symptoms in PwMS likely represents a direct result of such complex damage. Objective proxy measures to evaluate the nature/type of disease impact/progression could help identify therapy efficacy, and perhaps provide a path towards treatment decisions. OCT objectifies axonal damage by measurement of retinal fiber density. VEP-L objectifies demyelinating burden along some of the visual pathway.
Methods: Retrospective cross sectional analysis of PwMS who completed both VEP and OCT testing prospectively. Linear regression modeling was used to analyze significant relationships between VEP-L (right eye, left eye, interocular latency difference) and OCT outcomes [retinal nerve fiber layer-global (RNFL-G) and nasal/temporal ratio (RNFL-N/T), Perimacular Bundle (PMB) and Macular Volume (MV)] for each eye and hemispheric asymmetry. Significance was set at p< 0.01.
Results: PwMS n=99, 76.8% female, average age 50.5±10.4 years. Significant associations (p< 0.01) were identified: VEP-L OD correlated with RNFL-G OU, PMB OU, and MV OU; VEP-L OS correlated with RNFL-G OU, PMB OU, MV OU, and with RNFL-N/T hemispheric asymmetry. VEP-L interocular latency difference correlated with both eyes and OCT hemispheric asymmetry for RNFL-G, PMB, and MV outcomes.
Conclusions: OCT measurements (RNFL-G, PMB, and MV) correlated better with VEP-L findings in PwMS than did RNFL-N/T regardless of which eye was investigated. VEP-L interocular latency difference was significantly correlated to hemispheric asymmetry in these same OCT outcomes. Proxy measurements of both myelin and axonal injury are relevant to evaluate the types/degrees of MS related damage and specific OCT measurements might reflect partial aspects of CNS damage in PwMS. Future studies investigating these proxy measures both cross sectionally and longitudinally should target RNFL-G, PMB, and MV outcomes rather than RNFL-N/T and how these relate to patient-centered metrics, biomarkers, prognosis and therapy efficacy.
Disclosure: This study was not supported by any outside funding.
Tabiri K: nothing to disclose
Srinivasan J: nothing to disclose
Wissemann K: nothing to disclose
Anand D: nothing to disclose
Fafard L: nothing to disclose
Bumstead B: nothing to disclose
Buhse M: nothing to disclose
Zarif M: nothing to disclose
Blitz K: nothing to disclose
Sergott R: is a consultant to Heidelberg Engineering
Gudesblatt M: nothing to disclose