Contributions
Abstract: P969
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 14 Genetics/Epigenetics
Background: The distribution of courses of multiple sclerosis (MS) is well established. It is also well known that the etiology of MS has a familial component. But little is known about the distribution of courses among the familial MS cases. The hypothesis of this study is that the distribution of courses is different in familial cases compared to non-familial MS cases reflecting differences in the pathophysiology of relapsing and progressive MS.
Material and methods: This register study is a part of a neurogenetic Ph.D. project also involving clinical and molecular biological aspects of familial MS using data from the The Danish Multiple Sclerosis Register, The National Patient Register and The Danish Civil Register. We have defined a cohort of Danish MS patients diagnosed from 1994-2014 and included information on courses of MS and first degree relatives with MS. In this study we have defined familial MS as MS cases with 1 or more first degree relatives with MS.
Results: We have information on 25,471 MS patients from in The Danish Multiple Sclerosis Register. 12,537 of them are diagnosed from 1994-2014. Course of MS was first included in the Danish MS Registry in 1994, meaning that we have missing information in the first years of the total period. The MS cases missing information on courses are nearly equally distributed among familial and non-familial MS (35% vs 38%). Information on courses is missing in 4,755 MS cases.
We therefor included 7,782 MS cases in this study, 7,314 of them are in the non-familial group and 468 are in the familial group. Regarding the distribution of courses, 69.9 % from the familial MS group are relapsing-remitting MS (RRMS) compared to 65.0 % from the non-familiar MS group. 8.8 % of the familial MS group has primary progressive MS (PPMS) compared to 14.3 % of the non-familial group and among the secondary progressive MS (SPMS) cases there are 21.4 % in the familiar group and 20.7 % in the non-familial group. A logistic regression analysis is in process and will be presented at the congress.
Conclusion: In the preliminary results difference in the distribution of familial and non-familial MS
(8.8 % vs 14,3 %) in PPMS was found. There were no major differences among the distribution of familial and non-familial MS in RRMS and SPMS. Thus, the distribution of familial and non-familial MS may be different in different courses of MS. Further results will be presented at the Congress.
Disclosure: All authors declare: nothing to disclose.
Abstract: P969
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 14 Genetics/Epigenetics
Background: The distribution of courses of multiple sclerosis (MS) is well established. It is also well known that the etiology of MS has a familial component. But little is known about the distribution of courses among the familial MS cases. The hypothesis of this study is that the distribution of courses is different in familial cases compared to non-familial MS cases reflecting differences in the pathophysiology of relapsing and progressive MS.
Material and methods: This register study is a part of a neurogenetic Ph.D. project also involving clinical and molecular biological aspects of familial MS using data from the The Danish Multiple Sclerosis Register, The National Patient Register and The Danish Civil Register. We have defined a cohort of Danish MS patients diagnosed from 1994-2014 and included information on courses of MS and first degree relatives with MS. In this study we have defined familial MS as MS cases with 1 or more first degree relatives with MS.
Results: We have information on 25,471 MS patients from in The Danish Multiple Sclerosis Register. 12,537 of them are diagnosed from 1994-2014. Course of MS was first included in the Danish MS Registry in 1994, meaning that we have missing information in the first years of the total period. The MS cases missing information on courses are nearly equally distributed among familial and non-familial MS (35% vs 38%). Information on courses is missing in 4,755 MS cases.
We therefor included 7,782 MS cases in this study, 7,314 of them are in the non-familial group and 468 are in the familial group. Regarding the distribution of courses, 69.9 % from the familial MS group are relapsing-remitting MS (RRMS) compared to 65.0 % from the non-familiar MS group. 8.8 % of the familial MS group has primary progressive MS (PPMS) compared to 14.3 % of the non-familial group and among the secondary progressive MS (SPMS) cases there are 21.4 % in the familiar group and 20.7 % in the non-familial group. A logistic regression analysis is in process and will be presented at the congress.
Conclusion: In the preliminary results difference in the distribution of familial and non-familial MS
(8.8 % vs 14,3 %) in PPMS was found. There were no major differences among the distribution of familial and non-familial MS in RRMS and SPMS. Thus, the distribution of familial and non-familial MS may be different in different courses of MS. Further results will be presented at the Congress.
Disclosure: All authors declare: nothing to disclose.