Contributions
Abstract: P941
Type: Poster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Introduction: Comorbidities are common in patients with multiple sclerosis (MS), and many occur in greater frequency among patients with MS than those without MS. Data comparing the prevalence of comorbidities in patients with and without MS by age and sex are lacking. The objective of this research was to compare the prevalence of comorbidities in patients with and without MS within different age groups and by sex.
Methods: This retrospective database analysis used administrative claims data from the IMS Health Real World Data Adjudicated Claims - US database from 1/1/2011 to 30/9/2015. Patients with MS were required to have a minimum of 2 claims in which a diagnosis of MS (ICD-9-CM code = 340.xx) appeared in any diagnosis field between 1/1/2011 and 30/9/2015. In the first analysis, patients from 5 age cohorts were selected (18-24, 25-34, 35-44, 45-54 and 55-65 years). Patients were also evaluated by sex. The prevalence of common comorbidities in MS was assessed, and prevalence rates were compared between patients with and without MS within the age groupings and by sex. Exact matching was used to match patients with MS 1:1 to the pool of patients without MS within each grouping. Matching factors included age, geographic region and index year quarter.
Results: Anxiety, depression, gastrointestinal disease, hyperlipidaemia, hypertension and thyroid disease were all statistically significantly more prevalent in patients with MS compared with those without MS across all age groups (p< 0.0001 for all). Arthritis, chronic lung disease and diabetes were statistically significantly more prevalent in patients with MS compared with those without MS across all age groups except the 55-65 year group (p< 0.0001 for all other age groups). Anxiety, arthritis, chronic lung disease, depression, gastrointestinal disease, hyperlipidaemia, hypertension and thyroid disease were all statistically significantly more prevalent in patients with MS compared with those without MS in both women and men (p< 0.001). The prevalence of diabetes did not statistically significantly differ between patients with and without MS in either women or men (p>0.05).
Conclusions: Rates of several comorbidities differed in patients with MS compared with those without MS within various age groups and by sex. Some of these differences were not present in the oldest age group. Reasons for this finding have yet to be elucidated.
Disclosure: KK-R has received consulting fees from Biogen and EMD Serono, Inc.*; speakers fees and honoraria from Biogen, EMD Serono, Inc.,* Genzyme, Mallinckrodt, Novartis, and Teva; and grant/research support from Biogen, Genentech, Genzyme, Mallinckrodt, and Novartis. NCE is an employee of Health Services Consulting Corporation. Health Services Consulting Corporation received funding from EMD Serono, Inc.,* to run the analysis. ALP is an employee of EMD Serono, Inc.,* Rockland, MA, USA. *A business of Merck KGaA, Darmstadt, Germany.
Abstract: P941
Type: Poster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Introduction: Comorbidities are common in patients with multiple sclerosis (MS), and many occur in greater frequency among patients with MS than those without MS. Data comparing the prevalence of comorbidities in patients with and without MS by age and sex are lacking. The objective of this research was to compare the prevalence of comorbidities in patients with and without MS within different age groups and by sex.
Methods: This retrospective database analysis used administrative claims data from the IMS Health Real World Data Adjudicated Claims - US database from 1/1/2011 to 30/9/2015. Patients with MS were required to have a minimum of 2 claims in which a diagnosis of MS (ICD-9-CM code = 340.xx) appeared in any diagnosis field between 1/1/2011 and 30/9/2015. In the first analysis, patients from 5 age cohorts were selected (18-24, 25-34, 35-44, 45-54 and 55-65 years). Patients were also evaluated by sex. The prevalence of common comorbidities in MS was assessed, and prevalence rates were compared between patients with and without MS within the age groupings and by sex. Exact matching was used to match patients with MS 1:1 to the pool of patients without MS within each grouping. Matching factors included age, geographic region and index year quarter.
Results: Anxiety, depression, gastrointestinal disease, hyperlipidaemia, hypertension and thyroid disease were all statistically significantly more prevalent in patients with MS compared with those without MS across all age groups (p< 0.0001 for all). Arthritis, chronic lung disease and diabetes were statistically significantly more prevalent in patients with MS compared with those without MS across all age groups except the 55-65 year group (p< 0.0001 for all other age groups). Anxiety, arthritis, chronic lung disease, depression, gastrointestinal disease, hyperlipidaemia, hypertension and thyroid disease were all statistically significantly more prevalent in patients with MS compared with those without MS in both women and men (p< 0.001). The prevalence of diabetes did not statistically significantly differ between patients with and without MS in either women or men (p>0.05).
Conclusions: Rates of several comorbidities differed in patients with MS compared with those without MS within various age groups and by sex. Some of these differences were not present in the oldest age group. Reasons for this finding have yet to be elucidated.
Disclosure: KK-R has received consulting fees from Biogen and EMD Serono, Inc.*; speakers fees and honoraria from Biogen, EMD Serono, Inc.,* Genzyme, Mallinckrodt, Novartis, and Teva; and grant/research support from Biogen, Genentech, Genzyme, Mallinckrodt, and Novartis. NCE is an employee of Health Services Consulting Corporation. Health Services Consulting Corporation received funding from EMD Serono, Inc.,* to run the analysis. ALP is an employee of EMD Serono, Inc.,* Rockland, MA, USA. *A business of Merck KGaA, Darmstadt, Germany.