Contributions
Abstract: P935
Type: Poster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Aim: The aim of this population-based study was to determine comorbidity in multiple sclerosis (MS) in northeastern Poland. To date, no studies evaluating comorbidity in MS have been conducted in this region.
Materials and methods: Each participating patient, diagnosed in accordance with the McDonald criteria, completed a questionnaire and underwent a neurological examination. MS patients living in northeastern Poland were recorded in a patient registry. We compared our database with the local National Health Service registry (all patients presenting to healthcare facilities in the years 2012-2013 with a diagnosis of MS (ICD 10: G35)).
Results: 815 cases of MS (67.6% women and 32.4% men) were registered. The mean age of the patients was 47.7±12.2 years. The mean EDSS was 3.33±2.15. Most patients (89%) were not treated with disease-modifying therapies (DMTs). In our data, the most common comorbidities were hypertension (4.3%) and thyroid diseases (3.3%). Continuously or periodically, patients reported: pain (69.6%), urinary incontinence (39.2%, 44.9% of which was treated), depression (37.6%, 67% of which was treated) memory problems (39.2%), and fatigue (70.8%). Nicotine addiction was reported by 23.2% patients. In the local National Health Service data, the most common comorbidity was also hypertension (7.2% in 2012 n-1343; 8% in 2013 n-1299). The prevalence of hypertension gradually increased with age. Musculoskeletal diseases (according to ICD 10): M50-54 (4.3%); G54-55 (3%) were the most common in the age group of 55-64 years; M47-48 (3.7% in 2012; 5.4% in 2013, were the most common in the age group of 55-64 years); M15-M17 (1.7% in 2012, 2.5% in 2013). The third most common disease was urinary tract infection (3.2% in 2012, 3.5% in 2013). Next, depression F32-39 (1.7% in 2012, 2.4% in 2013), disorders of lipid metabolism E78 (1.4% in 2012, 2% in 2013), and diabetes E10-13 (1.3% in 2012, 2% in 2013) were reported. There were no statistical differences in the incidence of comorbidities comparing 2012 to 2013. It should be emphasized that in both years significantly higher incidence of diabetes and disorders of lipid metabolism was reported in men compared to women´s groups.
Conclusion: In northeastern Poland, most patients with multiple sclerosis untreated with DMTs do not suffer from any other diseases. The most common comorbidity in multiple sclerosis is hypertension. Diabetes and hyperlipidemia are higher in men than women.
Disclosure:
Katarzyna Kapica-Topczewska: nothing to disclose
Joanna Tarasiuk: nothing to disclose
Monika Chorąży: nothing to disclose
Waldemar Brola: nothing to disclose
Jan Kochanowicz: nothing to disclose
Alina Kułakowska: nothing to disclose
Abstract: P935
Type: Poster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Aim: The aim of this population-based study was to determine comorbidity in multiple sclerosis (MS) in northeastern Poland. To date, no studies evaluating comorbidity in MS have been conducted in this region.
Materials and methods: Each participating patient, diagnosed in accordance with the McDonald criteria, completed a questionnaire and underwent a neurological examination. MS patients living in northeastern Poland were recorded in a patient registry. We compared our database with the local National Health Service registry (all patients presenting to healthcare facilities in the years 2012-2013 with a diagnosis of MS (ICD 10: G35)).
Results: 815 cases of MS (67.6% women and 32.4% men) were registered. The mean age of the patients was 47.7±12.2 years. The mean EDSS was 3.33±2.15. Most patients (89%) were not treated with disease-modifying therapies (DMTs). In our data, the most common comorbidities were hypertension (4.3%) and thyroid diseases (3.3%). Continuously or periodically, patients reported: pain (69.6%), urinary incontinence (39.2%, 44.9% of which was treated), depression (37.6%, 67% of which was treated) memory problems (39.2%), and fatigue (70.8%). Nicotine addiction was reported by 23.2% patients. In the local National Health Service data, the most common comorbidity was also hypertension (7.2% in 2012 n-1343; 8% in 2013 n-1299). The prevalence of hypertension gradually increased with age. Musculoskeletal diseases (according to ICD 10): M50-54 (4.3%); G54-55 (3%) were the most common in the age group of 55-64 years; M47-48 (3.7% in 2012; 5.4% in 2013, were the most common in the age group of 55-64 years); M15-M17 (1.7% in 2012, 2.5% in 2013). The third most common disease was urinary tract infection (3.2% in 2012, 3.5% in 2013). Next, depression F32-39 (1.7% in 2012, 2.4% in 2013), disorders of lipid metabolism E78 (1.4% in 2012, 2% in 2013), and diabetes E10-13 (1.3% in 2012, 2% in 2013) were reported. There were no statistical differences in the incidence of comorbidities comparing 2012 to 2013. It should be emphasized that in both years significantly higher incidence of diabetes and disorders of lipid metabolism was reported in men compared to women´s groups.
Conclusion: In northeastern Poland, most patients with multiple sclerosis untreated with DMTs do not suffer from any other diseases. The most common comorbidity in multiple sclerosis is hypertension. Diabetes and hyperlipidemia are higher in men than women.
Disclosure:
Katarzyna Kapica-Topczewska: nothing to disclose
Joanna Tarasiuk: nothing to disclose
Monika Chorąży: nothing to disclose
Waldemar Brola: nothing to disclose
Jan Kochanowicz: nothing to disclose
Alina Kułakowska: nothing to disclose