Contributions
Abstract: P933
Type: Poster
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Introduction and purpose: The radiological isolated syndrome (RIS) defines MRI findings suggestive of multiple sclerosis (MS) in healthy individuals without signs of neurological dysfunction. Ocular motor disorders (OMDs) are a common feature of MS and may occur at all stages of the disease. The aim of this study is to measure the prevalence of sub-clinical OMDs using video-oculography (VOG) in RIS.
Methods: We assessed eye movements by VOG in a cohort of individuals with RIS referred to the universitary neurological department of Nimes and Nice hospitals (France). Eye movements were recorded using the Mobile EyeBrain Tracker. We tested for horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit in all subjects, and anti-saccades in four patients.
Results: Nine consecutive individuals fulfilling the RIS criteria underwent VOG. At least one abnormality of eye movements was found in all patients but one. Dysmetria of vertical and horizontal saccades was observed in five and in one subject respectively. Velocity of vertical saccades was reduced in one subject and of horizontal saccades in one subject. Latencies of saccades were normal in all subjects. Anti-saccades task was performed in four subjects and was pathological in all but one. Saccadic vertical pursuit was observed in three subjects. Horizontal pursuit was normal in all patients. In one patient we observed unilateral internuclear ophthalmoplegia. Significant saccadic intrusions were identified in five subjects.
Discussion: We assessed eye movements in a cohort of 9 individuals with RIS using VOG. To our best knowledge, this is first description of infraclinical OMDs in RIS. Vertical ocular movements were more often abnormal than horizontal ocular movements. We found that the prevalence of OMDs in RIS individuals is not very different when compared with CIS, RRMS and PPMS patients.
Conclusion: OMDs are frequently observed in RIS individuals. Clinical follow-up will allow us to assess whether detection of OMDs influences the risk of conversion to MS.
Disclosure: The authors are nothing to disclose
Abstract: P933
Type: Poster
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Introduction and purpose: The radiological isolated syndrome (RIS) defines MRI findings suggestive of multiple sclerosis (MS) in healthy individuals without signs of neurological dysfunction. Ocular motor disorders (OMDs) are a common feature of MS and may occur at all stages of the disease. The aim of this study is to measure the prevalence of sub-clinical OMDs using video-oculography (VOG) in RIS.
Methods: We assessed eye movements by VOG in a cohort of individuals with RIS referred to the universitary neurological department of Nimes and Nice hospitals (France). Eye movements were recorded using the Mobile EyeBrain Tracker. We tested for horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit in all subjects, and anti-saccades in four patients.
Results: Nine consecutive individuals fulfilling the RIS criteria underwent VOG. At least one abnormality of eye movements was found in all patients but one. Dysmetria of vertical and horizontal saccades was observed in five and in one subject respectively. Velocity of vertical saccades was reduced in one subject and of horizontal saccades in one subject. Latencies of saccades were normal in all subjects. Anti-saccades task was performed in four subjects and was pathological in all but one. Saccadic vertical pursuit was observed in three subjects. Horizontal pursuit was normal in all patients. In one patient we observed unilateral internuclear ophthalmoplegia. Significant saccadic intrusions were identified in five subjects.
Discussion: We assessed eye movements in a cohort of 9 individuals with RIS using VOG. To our best knowledge, this is first description of infraclinical OMDs in RIS. Vertical ocular movements were more often abnormal than horizontal ocular movements. We found that the prevalence of OMDs in RIS individuals is not very different when compared with CIS, RRMS and PPMS patients.
Conclusion: OMDs are frequently observed in RIS individuals. Clinical follow-up will allow us to assess whether detection of OMDs influences the risk of conversion to MS.
Disclosure: The authors are nothing to disclose