Contributions
Abstract: P915
Type: Poster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Brain volume has been suggested and explored as the cause of cognitive impairment patients with Multiple Sclerosis (MS). Optical coherence tomography (OCT) has been linked with brain atrophy and ongoing studies continue to explore this relationship.
Objective: We explored the relationship between OCT and the presence of cognitive impairment in patients with MS compared to healthy controls.
Methods: A prospective collection of OCT scans and scores from the symbols digit modality test(SDMT) were analyzed in 20 patients with MS and 20 healthy controls between the ages of 18-59.
Results: Demographics included in the MS group (70% female, average age 43 +/-10.9, average disease duration 8.2 years +/-6.9), and on 20 healthy controls (55% female, average age 38.1 +/-10.7). As expected, an Independent Samples T-test comparing the SDMT scores of the MS group to the control group showed that there was a significant difference in the MS group SDMT scores (M=48.05, SD=11.61) and control group SDMT scores(M=63.15, SD=11.82); t(38)=-4.07, p< .01, 95% CI [-22.60, -7.59]. Also expected, an Independent Samples T-test comparing the RNFL measures G of OD, G of OS, PMB of OD and PMB of OS of the MS group to the control group showed that there was a significant difference between the groups: G of OD(t(38)=-3.00, p< .01), G of OS(t(38)=-3.00, p=.021), PMB of OD(t(38)=-2.96, p< .01); and PMB of OS approached significance (t(38)=-1.75, p=.087).
In order to observe the relationship between SDMT performance and RNFL values, participants were divided into 2 groups: “within normal range,” and “above or below normal range.” Pearson correlation performed on the SDMT scores and RNFL groups was highly significant in both the right eye (r=.42, p< .01) and the left eye (r=.37, p< .01).
Conclusion: There is a significant correlation between RNFL values and cognitive disability. As suggested in other studies, the OCT may serve as a valuable screen for axonal loss and degeneration.
Disclosure:
Krupa Pandey: This study was unfunded. Dr. Pandey serves on the speaker bureaus for Biogen, Genzyme, Genentech and Teva. She serves as a consultant for Biogen, Genzyme and Genentech.
Ms. Russell-Gillen and Mohn have nothing to disclose
Abstract: P915
Type: Poster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Brain volume has been suggested and explored as the cause of cognitive impairment patients with Multiple Sclerosis (MS). Optical coherence tomography (OCT) has been linked with brain atrophy and ongoing studies continue to explore this relationship.
Objective: We explored the relationship between OCT and the presence of cognitive impairment in patients with MS compared to healthy controls.
Methods: A prospective collection of OCT scans and scores from the symbols digit modality test(SDMT) were analyzed in 20 patients with MS and 20 healthy controls between the ages of 18-59.
Results: Demographics included in the MS group (70% female, average age 43 +/-10.9, average disease duration 8.2 years +/-6.9), and on 20 healthy controls (55% female, average age 38.1 +/-10.7). As expected, an Independent Samples T-test comparing the SDMT scores of the MS group to the control group showed that there was a significant difference in the MS group SDMT scores (M=48.05, SD=11.61) and control group SDMT scores(M=63.15, SD=11.82); t(38)=-4.07, p< .01, 95% CI [-22.60, -7.59]. Also expected, an Independent Samples T-test comparing the RNFL measures G of OD, G of OS, PMB of OD and PMB of OS of the MS group to the control group showed that there was a significant difference between the groups: G of OD(t(38)=-3.00, p< .01), G of OS(t(38)=-3.00, p=.021), PMB of OD(t(38)=-2.96, p< .01); and PMB of OS approached significance (t(38)=-1.75, p=.087).
In order to observe the relationship between SDMT performance and RNFL values, participants were divided into 2 groups: “within normal range,” and “above or below normal range.” Pearson correlation performed on the SDMT scores and RNFL groups was highly significant in both the right eye (r=.42, p< .01) and the left eye (r=.37, p< .01).
Conclusion: There is a significant correlation between RNFL values and cognitive disability. As suggested in other studies, the OCT may serve as a valuable screen for axonal loss and degeneration.
Disclosure:
Krupa Pandey: This study was unfunded. Dr. Pandey serves on the speaker bureaus for Biogen, Genzyme, Genentech and Teva. She serves as a consultant for Biogen, Genzyme and Genentech.
Ms. Russell-Gillen and Mohn have nothing to disclose