Contributions
Abstract: P890
Type: Poster
Abstract Category: Clinical aspects of MS - 6 MS and gender
Introduction: Data regarding rates of pregnancy over time in women with multiple sclerosis (MS) versus women without MS are lacking. This study aimed to evaluate the annual prevalence of pregnancy in women with and without MS from 2006 to 2014.
Methods: IMS Health Real World Data Adjudicated Claims - US data were used to identify annual cohorts of US women with and without MS (International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code: 340.xx) between calendar year (CY) 2006 and CY2014. Annual pregnancy rates (identified via applicable diagnosis or procedure codes), adjusted for age, region, payer, and Charlson Comorbidity Index (CCI), were estimated separately among women with and without MS via logistic regression. Without MS estimates were conducted on a 5% random sample. Statistical comparison of the year-over-year pregnancy rates (ie, slope of best fit line estimated via linear regression) among women with and without MS during the CY2006-CY2014 study interval were conducted.
Results: The number of women with MS included in the nine annual study cohorts ranged from 39,801 to 59,622; those without MS ranged from 735,974 to 1,144,868. The mean age of pregnant women with MS was greater than that of pregnant women without MS (approximately 32.5 vs. 29.3 years), with little year-to-year variation. The adjusted proportion of women with MS who had a pregnancy increased from 7.91% in 2006 to 9.47% in 2014. The adjusted proportion of women without MS who had a pregnancy decreased from 8.83% in 2006 to 7.75% in 2014. The difference in linear trend between women with and without MS (0.17% increase and -0.15% decrease in per annum pregnancy rates, respectively) was statistically significant (t-statistic=7.8, p< 0.0001).
Conclusions: After adjustment for age, region, payer, and CCI, the proportion of women with MS who had a pregnancy increased from 2006 to 2014, while the proportion of women without MS who had a pregnancy decreased from 2006 to 2014.
Disclosure: MKH received funding support from EMD Serono, Inc.*; received support for service on scientific advisory boards from Biogen, Genzyme Sanofi, Teva Neuroscience, and Novartis; and received research support from Genzyme Sanofi.
NCE is an employee of Health Services Consulting Corporation. Health Services Consulting Corporation received funding from EMD Serono, Inc.* to run the analysis.
ALP is an employee of EMD Serono, Inc.,* Rockland, MA, USA. KS and GS are employees of Boston Health Economics, Inc. (BHE). BHE received consulting fees from EMD Serono, Inc.*
*A business of Merck KGaA, Darmstadt, Germany.
Abstract: P890
Type: Poster
Abstract Category: Clinical aspects of MS - 6 MS and gender
Introduction: Data regarding rates of pregnancy over time in women with multiple sclerosis (MS) versus women without MS are lacking. This study aimed to evaluate the annual prevalence of pregnancy in women with and without MS from 2006 to 2014.
Methods: IMS Health Real World Data Adjudicated Claims - US data were used to identify annual cohorts of US women with and without MS (International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code: 340.xx) between calendar year (CY) 2006 and CY2014. Annual pregnancy rates (identified via applicable diagnosis or procedure codes), adjusted for age, region, payer, and Charlson Comorbidity Index (CCI), were estimated separately among women with and without MS via logistic regression. Without MS estimates were conducted on a 5% random sample. Statistical comparison of the year-over-year pregnancy rates (ie, slope of best fit line estimated via linear regression) among women with and without MS during the CY2006-CY2014 study interval were conducted.
Results: The number of women with MS included in the nine annual study cohorts ranged from 39,801 to 59,622; those without MS ranged from 735,974 to 1,144,868. The mean age of pregnant women with MS was greater than that of pregnant women without MS (approximately 32.5 vs. 29.3 years), with little year-to-year variation. The adjusted proportion of women with MS who had a pregnancy increased from 7.91% in 2006 to 9.47% in 2014. The adjusted proportion of women without MS who had a pregnancy decreased from 8.83% in 2006 to 7.75% in 2014. The difference in linear trend between women with and without MS (0.17% increase and -0.15% decrease in per annum pregnancy rates, respectively) was statistically significant (t-statistic=7.8, p< 0.0001).
Conclusions: After adjustment for age, region, payer, and CCI, the proportion of women with MS who had a pregnancy increased from 2006 to 2014, while the proportion of women without MS who had a pregnancy decreased from 2006 to 2014.
Disclosure: MKH received funding support from EMD Serono, Inc.*; received support for service on scientific advisory boards from Biogen, Genzyme Sanofi, Teva Neuroscience, and Novartis; and received research support from Genzyme Sanofi.
NCE is an employee of Health Services Consulting Corporation. Health Services Consulting Corporation received funding from EMD Serono, Inc.* to run the analysis.
ALP is an employee of EMD Serono, Inc.,* Rockland, MA, USA. KS and GS are employees of Boston Health Economics, Inc. (BHE). BHE received consulting fees from EMD Serono, Inc.*
*A business of Merck KGaA, Darmstadt, Germany.