Contributions
Abstract: P884
Type: Poster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
The spectrum of idiopathic inflammatory demyelinating central nervous system disease (CNS-IIDD) includes neuromyelitis optica spectrum disorders (NMOSD) and Multiple sclerosis (MS). They are characterized by neurological deficits disseminated in time and space with serious repercussions on daily life activities. Lethality studies contributes to the prognosis and to evaluate the impact of therapeutic strategies on long-term outcomes. We studied the lethality rates of MS and NMOSD patients followed since the onset of clinic service for CNS-IIDD in HUCFF/UFRJ, Rio de Janeiro/Brasil, in 1995. The diagnosis of MS was based on McDonald's criteria and all cases of NMOSD were reviewed applying the new diagnostic criteria. Demographic factors such as age at onset, ethnicity, and gender were collected along with clinical features such as annualized relapse rate, disease duration, functional systems at first relapse, first two-years relapse ratio, interval time to EDSS 3, 4, 6, 7 and 8, and therapeutic response. Among 183 individuals with MS and 83 with NMOSD, females predominated in both conditions. The mean age of first relapse was higher among NMOSD patients: 31.12 (±11.05) (mean-SD) for the latter, against 27±9.39 (mean-SD) for MS . Caucasians were the predominant ethnicity in both MS (73%) and NMOSD (65%) groups; besides, as we expected, afro-brazilians were more frequent among NMOSD patients (35% vs 27%). The long-term follow-up (22-years in the majority of patients) allowed us to estimate lethality rates and its causes. In NMOSD we've found a lethality rate of 4,81%, as twice as found in MS patients (2,18%). The most common causes of death in NMOSD included severe respiratory infection and pulmonary sepsis; in MS, gastric adenocarcinomatosis and urinary sepsis. Regarding demographic factors, our findings were very similar to literature. However, lethality data still lacks; it is important to estimate and establish its main causes, so such events are preventable.
Disclosure:
João Gabriel Dib Farinhas Valeria Coelho Santa Rita Pereira, Fabíola Rachid Malfetano, Simone Batista Scherpenhuijzen, Vanderson Carvalho Neri and Soniza Vieira Alves-Leon have received consulting and lecture fees
Fabrícia Lima Fontes-Dantas, Laise Caroline França, Amanda Dutra de Araújo and André Peres: nothing to disclose.
Abstract: P884
Type: Poster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
The spectrum of idiopathic inflammatory demyelinating central nervous system disease (CNS-IIDD) includes neuromyelitis optica spectrum disorders (NMOSD) and Multiple sclerosis (MS). They are characterized by neurological deficits disseminated in time and space with serious repercussions on daily life activities. Lethality studies contributes to the prognosis and to evaluate the impact of therapeutic strategies on long-term outcomes. We studied the lethality rates of MS and NMOSD patients followed since the onset of clinic service for CNS-IIDD in HUCFF/UFRJ, Rio de Janeiro/Brasil, in 1995. The diagnosis of MS was based on McDonald's criteria and all cases of NMOSD were reviewed applying the new diagnostic criteria. Demographic factors such as age at onset, ethnicity, and gender were collected along with clinical features such as annualized relapse rate, disease duration, functional systems at first relapse, first two-years relapse ratio, interval time to EDSS 3, 4, 6, 7 and 8, and therapeutic response. Among 183 individuals with MS and 83 with NMOSD, females predominated in both conditions. The mean age of first relapse was higher among NMOSD patients: 31.12 (±11.05) (mean-SD) for the latter, against 27±9.39 (mean-SD) for MS . Caucasians were the predominant ethnicity in both MS (73%) and NMOSD (65%) groups; besides, as we expected, afro-brazilians were more frequent among NMOSD patients (35% vs 27%). The long-term follow-up (22-years in the majority of patients) allowed us to estimate lethality rates and its causes. In NMOSD we've found a lethality rate of 4,81%, as twice as found in MS patients (2,18%). The most common causes of death in NMOSD included severe respiratory infection and pulmonary sepsis; in MS, gastric adenocarcinomatosis and urinary sepsis. Regarding demographic factors, our findings were very similar to literature. However, lethality data still lacks; it is important to estimate and establish its main causes, so such events are preventable.
Disclosure:
João Gabriel Dib Farinhas Valeria Coelho Santa Rita Pereira, Fabíola Rachid Malfetano, Simone Batista Scherpenhuijzen, Vanderson Carvalho Neri and Soniza Vieira Alves-Leon have received consulting and lecture fees
Fabrícia Lima Fontes-Dantas, Laise Caroline França, Amanda Dutra de Araújo and André Peres: nothing to disclose.