Contributions
Abstract: P868
Type: Poster
Abstract Category: Clinical aspects of MS - 4 Natural course
Background: Multiple Sclerosis (MS) is a progressive inflammatory and degenerative disease of the central nervous system. Previous studies have suggested that older age at onset of MS is a risk factor for poor clinical prognosis. The aim of this study is to quantify the rate of disease progression among patients with differing ages of MS onset.
Methods: This is a cross-sectional retrospective data analysis using a clinical database containing patient data from a single tertiary care MS center after IRB approval. Patients were divided into different groups based on age at time of diagnosis: 10-20, 20-29, 30-39, 40-49, and >50. Rate of disease progression was calculated using expanded disability status scale (EDSS) score divided by years since diagnosis.
Results: A total of 854 patients age 18 to 65 with a diagnosis of MS were included in the study (F=620, M=234). Of these patients 612 (71.6%) carried a diagnosis of relapsing remitting MS (RRMS), 179 (21.0%) carried a diagnosis of secondary progressive MS (SPMS), and 63 (7.4%) carried a diagnosis of primary progressive MS (PPMS). Patients stratified by age of onset comprised of N=36 for age 10-20, N=229 for age 20-29, N=269 for age 30-39, N=214 for age 40-49, and N=106 for age >50. >90% of patients were either currently on or had prior exposure to disease modifying therapy (DMT). EDSS change per year was the lowest in patients diagnosed at age < 20 (0.17) and increased with higher age at the time of diagnosis (20-29=0.21, 30-39=0.22, 40-49=0.33, and >50=0.67; p< 0.001). For PPMS patients the rate of EDSS change per year was higher when compared to the rate of EDSS change per year for patients with a diagnosis of either RRMS or SPMS (0.84 vs. 0.26, p< 0.001).
Conclusion: The rate of disability progression correlates with age at diagnosis and progressively worsens with increasing age at diagnosis. The rate of disability progression in patients with PPMS is higher than in patients with a diagnosis of either RRMS or SPMS.
Disclosure:
Brian Wong: nothing to disclose
Jonathan Cahill: nothing to disclose
Andrew Bouley: nothing to disclose
Alison Daigle: nothing to disclose
Tinting Zhang: nothing to disclose
Syed Rizvi: nothing to disclose
Abstract: P868
Type: Poster
Abstract Category: Clinical aspects of MS - 4 Natural course
Background: Multiple Sclerosis (MS) is a progressive inflammatory and degenerative disease of the central nervous system. Previous studies have suggested that older age at onset of MS is a risk factor for poor clinical prognosis. The aim of this study is to quantify the rate of disease progression among patients with differing ages of MS onset.
Methods: This is a cross-sectional retrospective data analysis using a clinical database containing patient data from a single tertiary care MS center after IRB approval. Patients were divided into different groups based on age at time of diagnosis: 10-20, 20-29, 30-39, 40-49, and >50. Rate of disease progression was calculated using expanded disability status scale (EDSS) score divided by years since diagnosis.
Results: A total of 854 patients age 18 to 65 with a diagnosis of MS were included in the study (F=620, M=234). Of these patients 612 (71.6%) carried a diagnosis of relapsing remitting MS (RRMS), 179 (21.0%) carried a diagnosis of secondary progressive MS (SPMS), and 63 (7.4%) carried a diagnosis of primary progressive MS (PPMS). Patients stratified by age of onset comprised of N=36 for age 10-20, N=229 for age 20-29, N=269 for age 30-39, N=214 for age 40-49, and N=106 for age >50. >90% of patients were either currently on or had prior exposure to disease modifying therapy (DMT). EDSS change per year was the lowest in patients diagnosed at age < 20 (0.17) and increased with higher age at the time of diagnosis (20-29=0.21, 30-39=0.22, 40-49=0.33, and >50=0.67; p< 0.001). For PPMS patients the rate of EDSS change per year was higher when compared to the rate of EDSS change per year for patients with a diagnosis of either RRMS or SPMS (0.84 vs. 0.26, p< 0.001).
Conclusion: The rate of disability progression correlates with age at diagnosis and progressively worsens with increasing age at diagnosis. The rate of disability progression in patients with PPMS is higher than in patients with a diagnosis of either RRMS or SPMS.
Disclosure:
Brian Wong: nothing to disclose
Jonathan Cahill: nothing to disclose
Andrew Bouley: nothing to disclose
Alison Daigle: nothing to disclose
Tinting Zhang: nothing to disclose
Syed Rizvi: nothing to disclose