Contributions
Abstract: P862
Type: Poster
Abstract Category: Clinical aspects of MS - 3 Paediatric MS
Background and goals: Pregnancies in Multiple Sclerosis (MS) women are reported to be well tolerated in general. However, maternal factors, as deficient nutritional status and uterine neuronal dysfunction, may influence intrauterine conditions and fetal growth. We sought to evaluate obstetrical and newborn outcomes in women with MS.
Methods: Pregnant women with the diagnosis of Relapse Remitting MS were recruited from the department's demyelinating diseases outpatient clinic between 2010-2015. Pregnancy data, mode of delivery and respective complications were evaluated. Considering newborn outcomes, spontaneous abortion was considered when occurred fetal loss before 22 gestational weeks; birth asphyxia were defined as 5 minute APGAR (Appearance, Pulse, Grimace, Activity, Respiration) score under 7 and low birth weight was defined as less than 2500g.
Results: In the study were included 84 pregnancies, with 77 resulting in live-infants, 6 spontaneous abortions and 1 voluntary abortion. The mean disease duration prior to pregnancy was 5.5 ± 2.8 years, with mean Expanded Disability Status Scale (EDSS) of 1.5 ± 0.8. The mean age at pregnancy was 32.5 ± 4.2 years, and the mean duration of pregnancy was 38.9 ± 1.7 weeks, with 7.8% of preterm deliveries. For 77.9% of our patients this was their first pregnancy. Restriction of intrauterine fetal growth was the most frequent pregnancy complication and no malformations were registered. 41.2% of our women had a caesarean delivery, mostly due to fetal-pelvic conflict. Birth asphyxia was registered in 7.5% of newborns. The mean newborn weight was 3080.2 ± 412.6g, with 7.0% of low birth weight.
Conclusion: Comparing the results to those for general Portuguese women from Portuguese National Statistical Institute (2010), our MS patients had a higher percentage of caesarean delivery, a similar percentage of preterm delivery and a lower percentage of low birth weight. Overall, MS did not seem to have a negative impact in newborn outcome.
Disclosure:
Joana Ribeiro: nothing to disclose
Inês Correia: nothing to disclose
Inês Martins: nothing to disclose
Manuel Fonseca: nothing to disclose
Inês Marques: nothing to disclose
Sónia Batista: nothing to disclose
Carla Nunes: nothing to disclose
Carmo Macário: nothing to disclose
Céu Almeida: nothing to disclose
Lívia Sousa: nothing to disclose
Abstract: P862
Type: Poster
Abstract Category: Clinical aspects of MS - 3 Paediatric MS
Background and goals: Pregnancies in Multiple Sclerosis (MS) women are reported to be well tolerated in general. However, maternal factors, as deficient nutritional status and uterine neuronal dysfunction, may influence intrauterine conditions and fetal growth. We sought to evaluate obstetrical and newborn outcomes in women with MS.
Methods: Pregnant women with the diagnosis of Relapse Remitting MS were recruited from the department's demyelinating diseases outpatient clinic between 2010-2015. Pregnancy data, mode of delivery and respective complications were evaluated. Considering newborn outcomes, spontaneous abortion was considered when occurred fetal loss before 22 gestational weeks; birth asphyxia were defined as 5 minute APGAR (Appearance, Pulse, Grimace, Activity, Respiration) score under 7 and low birth weight was defined as less than 2500g.
Results: In the study were included 84 pregnancies, with 77 resulting in live-infants, 6 spontaneous abortions and 1 voluntary abortion. The mean disease duration prior to pregnancy was 5.5 ± 2.8 years, with mean Expanded Disability Status Scale (EDSS) of 1.5 ± 0.8. The mean age at pregnancy was 32.5 ± 4.2 years, and the mean duration of pregnancy was 38.9 ± 1.7 weeks, with 7.8% of preterm deliveries. For 77.9% of our patients this was their first pregnancy. Restriction of intrauterine fetal growth was the most frequent pregnancy complication and no malformations were registered. 41.2% of our women had a caesarean delivery, mostly due to fetal-pelvic conflict. Birth asphyxia was registered in 7.5% of newborns. The mean newborn weight was 3080.2 ± 412.6g, with 7.0% of low birth weight.
Conclusion: Comparing the results to those for general Portuguese women from Portuguese National Statistical Institute (2010), our MS patients had a higher percentage of caesarean delivery, a similar percentage of preterm delivery and a lower percentage of low birth weight. Overall, MS did not seem to have a negative impact in newborn outcome.
Disclosure:
Joana Ribeiro: nothing to disclose
Inês Correia: nothing to disclose
Inês Martins: nothing to disclose
Manuel Fonseca: nothing to disclose
Inês Marques: nothing to disclose
Sónia Batista: nothing to disclose
Carla Nunes: nothing to disclose
Carmo Macário: nothing to disclose
Céu Almeida: nothing to disclose
Lívia Sousa: nothing to disclose