Contributions
Abstract: P854
Type: Poster
Abstract Category: Clinical aspects of MS - 2 MS Variants
MRI lesions suggestive of multiple sclerosis (MS) in the absence of a clinical scenario is a condition named ''radiologically isolated syndrome'' (RIS). The objective was to compare brain volume loss (BVL) in RIS subjects compared with early stages of relapsing remitting MS.
Methods: A retrospective review of RIS cases with at least 2 years of follow up was performed. Sex and age matched RRMS patients, with less than three years from disease onset, EDSS ≤3, follow up time of at least 2 years since disease onset and in which IFN beta 1-a 44 mcg was used, were included as a control group. MR scans were acquired 3 to 6 months after the initiation of IFN beta 1-a treatment and every 12 months after during 2 years in RRMS patients and every 6 months in RIS. Demographic, clinical and structural parameters from the MR scan, such as total brain volume, white matter volume, neocortical grey matter volume and PBVC during the 2 years of follow up were analyzed using SIENA and SIENAXr.
Results: 15 subjects with RIS and 65 RRMS patients were included (mean follow up time 33.6 ± 12 months). 5 (33%) of RIS progressed clinically (3 to CIS, 2 to RRMS) over a mean time of 22 ± 6 months from the date of RIS identification. No RIS subjects received DMDs treatment. PBVC during the period of time between baseline and month 12 was -0.75% in RRMS and -0.47 % in RIS (p< 0.01); between month 12 to 24 was -0.53% in RRMS vs. -0.51 in RIS (p=0.09); and for the entire period (0 to 24 months) -1.12 % for RRMS vs. -1.05 (p=0.06).
Conclusion: we observed a decrease in BVL in RIS similar to RRMS patients. Future studies will help to confirm this finding.
Disclosure: No funding for the research
Abstract: P854
Type: Poster
Abstract Category: Clinical aspects of MS - 2 MS Variants
MRI lesions suggestive of multiple sclerosis (MS) in the absence of a clinical scenario is a condition named ''radiologically isolated syndrome'' (RIS). The objective was to compare brain volume loss (BVL) in RIS subjects compared with early stages of relapsing remitting MS.
Methods: A retrospective review of RIS cases with at least 2 years of follow up was performed. Sex and age matched RRMS patients, with less than three years from disease onset, EDSS ≤3, follow up time of at least 2 years since disease onset and in which IFN beta 1-a 44 mcg was used, were included as a control group. MR scans were acquired 3 to 6 months after the initiation of IFN beta 1-a treatment and every 12 months after during 2 years in RRMS patients and every 6 months in RIS. Demographic, clinical and structural parameters from the MR scan, such as total brain volume, white matter volume, neocortical grey matter volume and PBVC during the 2 years of follow up were analyzed using SIENA and SIENAXr.
Results: 15 subjects with RIS and 65 RRMS patients were included (mean follow up time 33.6 ± 12 months). 5 (33%) of RIS progressed clinically (3 to CIS, 2 to RRMS) over a mean time of 22 ± 6 months from the date of RIS identification. No RIS subjects received DMDs treatment. PBVC during the period of time between baseline and month 12 was -0.75% in RRMS and -0.47 % in RIS (p< 0.01); between month 12 to 24 was -0.53% in RRMS vs. -0.51 in RIS (p=0.09); and for the entire period (0 to 24 months) -1.12 % for RRMS vs. -1.05 (p=0.06).
Conclusion: we observed a decrease in BVL in RIS similar to RRMS patients. Future studies will help to confirm this finding.
Disclosure: No funding for the research