Contributions
Abstract: P849
Type: Poster
Abstract Category: Clinical aspects of MS - 2 MS Variants
We aim to present the clinical features of MOG-ab-positive CNS inflammatory demyelinating diseases (MOG-IDDs) in a Chinese Han cohort and compare clinical features between patients with MOG-IDDs and NMOSD. The clinical data of 31 MOG-ab-seropositive patients and 28 AQP4-ab-seropositive patients was retrospectively reviewed. Among patients with MOG-IDDs, the mean onset age was 28 years and the female to male ratio was 1.2:1. The median disease duration was 18 months. Ratio of monophasic to relapsing was 1:3.4. ON was the most common onset presentation (64.5%), followed by cerebral syndrome (22.6%) and brainstem syndrome (12.9%). 61.3% of the MOG-ab-seropositive patients presented with intracranial lesion. These lesions might distributed in parietal lobe (63.2%), frontal lobe (52.6%), temporal lobe (47.4%) and occipital lobe (36.8%). Brainstem lesions were also observed (52.6%), with lesions in pons being the most common. Involvement of thalamus (26.3%), basal ganglia (26.3%), cerebellum (15.8%) and corpus callosum (15.8%) was also observed. We observed four types of brain lesions on MRI: 1) midline structure or deep grey matter lesion (68.8%, Fig 1A, F, G), 2) juxtacortical white matter lesion (56.3%, Fig 1B, E), 3) large, edematous white matter lesion (25.0%, Fig 1C), 4) non-specific lesion around lateral ventricle angle (31.3%, Fig 1D). Dorsal brain stem lesion around the fourth ventricle was also seen in 1 patient (Fig 1G), but no patient had ever had postrema syndrome. Gadolinium-enhanced T1-weighted imaging revealed patchy enhancement in some cases (Fig 1H). Microbleeds of brain lesion was observed in 2 of 7 patients that had underwent SWI (2/7, Fig 1I). 5 patients had spinal cord lesion, with median length 4 segments. Compared to patients with positive AQP4-ab, patients with positive MOG-ab demonstrated significantly higher female to male ratio (p=0.004) and higher possibility of recurrence (p=0.002), with myelitis less commonly seen at disease onset (p< 0.0001). There was no significant difference of onset age, disease duration, CSF protein, CSF WBC or other concommitant autoimmune-antibodies (including TPO-ab, TG-ab, TR-ab, ANA, SSA, RO-52).
Disclosure: The authors have no financial conflicts of interest.
Abstract: P849
Type: Poster
Abstract Category: Clinical aspects of MS - 2 MS Variants
We aim to present the clinical features of MOG-ab-positive CNS inflammatory demyelinating diseases (MOG-IDDs) in a Chinese Han cohort and compare clinical features between patients with MOG-IDDs and NMOSD. The clinical data of 31 MOG-ab-seropositive patients and 28 AQP4-ab-seropositive patients was retrospectively reviewed. Among patients with MOG-IDDs, the mean onset age was 28 years and the female to male ratio was 1.2:1. The median disease duration was 18 months. Ratio of monophasic to relapsing was 1:3.4. ON was the most common onset presentation (64.5%), followed by cerebral syndrome (22.6%) and brainstem syndrome (12.9%). 61.3% of the MOG-ab-seropositive patients presented with intracranial lesion. These lesions might distributed in parietal lobe (63.2%), frontal lobe (52.6%), temporal lobe (47.4%) and occipital lobe (36.8%). Brainstem lesions were also observed (52.6%), with lesions in pons being the most common. Involvement of thalamus (26.3%), basal ganglia (26.3%), cerebellum (15.8%) and corpus callosum (15.8%) was also observed. We observed four types of brain lesions on MRI: 1) midline structure or deep grey matter lesion (68.8%, Fig 1A, F, G), 2) juxtacortical white matter lesion (56.3%, Fig 1B, E), 3) large, edematous white matter lesion (25.0%, Fig 1C), 4) non-specific lesion around lateral ventricle angle (31.3%, Fig 1D). Dorsal brain stem lesion around the fourth ventricle was also seen in 1 patient (Fig 1G), but no patient had ever had postrema syndrome. Gadolinium-enhanced T1-weighted imaging revealed patchy enhancement in some cases (Fig 1H). Microbleeds of brain lesion was observed in 2 of 7 patients that had underwent SWI (2/7, Fig 1I). 5 patients had spinal cord lesion, with median length 4 segments. Compared to patients with positive AQP4-ab, patients with positive MOG-ab demonstrated significantly higher female to male ratio (p=0.004) and higher possibility of recurrence (p=0.002), with myelitis less commonly seen at disease onset (p< 0.0001). There was no significant difference of onset age, disease duration, CSF protein, CSF WBC or other concommitant autoimmune-antibodies (including TPO-ab, TG-ab, TR-ab, ANA, SSA, RO-52).
Disclosure: The authors have no financial conflicts of interest.