Contributions
Abstract: P645
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 25 Biomarkers
Objective: To prospectively assess the development of olfactory function in multiple sclerosis over time and its correlation with occurrence of relapse and disability progression.
Methods: In this prospective, 3-year longitudinal study on 151 MS patients and 30 healthy controls, three different qualities of olfactory function (threshold, discrimination and identification) were quantified using the Sniffin' Sticks test. The influence of occurrence of relapses and expanded disability status scale (EDSS) on olfactory function was analyzed at different timepoints. We conducted a multivariate logistic regression model including baseline covariates (age, sex, disease duration, EDSS, cognitive dysfunction and disease modifying treatment) to assess the association between olfactory function at baseline and occurrence of relapse and EDSS progression.
Results: Odor discrimination and identification capability significantly worsened over three years in MS patients, while olfactory threshold did not. Threshold was markedly impaired in patients with relapse activity within 12 months, recovered in the absence of relapse and was associated with a 2.5-fold increased risk of relapse within three years when measured at baseline. Deterioration of discrimination and identification was irreversible and was both strongly associated with and predictive of EDSS progression.
Conclusions: Olfactory function changes over time in MS. Impairment of threshold is transient and a predictor of inflammatory disease activity, while odor identification and discrimination are associated with disability progression. Olfactory dysfunction might be a useful and easily obtainable parameter to monitor patients with regard to inflammation and neurodegeneration in MS.
Disclosure:
Gabriel Bsteh - conflicts of interest: none.
Harald Hegen - conflicts of interest: none.
Klaus Berek - conflicts of interest: none.
Felix Ladstätter - conflicts of interest: none.
Matthias Amprosi - conflicts of interest: none.
Sebastian Wurth - conflicts of interest: none.
Michael Auer - conflicts of interest: none.
Franziska Di Pauli - conflicts of interest: none.
Florian Deisenhammer - conflicts of interest: none.
Markus Reindl - conflicts of interest: none.
Thomas Berger - conflicts of interest: none.
Andreas Lutterotti - conflicts of interest: none.
Abstract: P645
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 25 Biomarkers
Objective: To prospectively assess the development of olfactory function in multiple sclerosis over time and its correlation with occurrence of relapse and disability progression.
Methods: In this prospective, 3-year longitudinal study on 151 MS patients and 30 healthy controls, three different qualities of olfactory function (threshold, discrimination and identification) were quantified using the Sniffin' Sticks test. The influence of occurrence of relapses and expanded disability status scale (EDSS) on olfactory function was analyzed at different timepoints. We conducted a multivariate logistic regression model including baseline covariates (age, sex, disease duration, EDSS, cognitive dysfunction and disease modifying treatment) to assess the association between olfactory function at baseline and occurrence of relapse and EDSS progression.
Results: Odor discrimination and identification capability significantly worsened over three years in MS patients, while olfactory threshold did not. Threshold was markedly impaired in patients with relapse activity within 12 months, recovered in the absence of relapse and was associated with a 2.5-fold increased risk of relapse within three years when measured at baseline. Deterioration of discrimination and identification was irreversible and was both strongly associated with and predictive of EDSS progression.
Conclusions: Olfactory function changes over time in MS. Impairment of threshold is transient and a predictor of inflammatory disease activity, while odor identification and discrimination are associated with disability progression. Olfactory dysfunction might be a useful and easily obtainable parameter to monitor patients with regard to inflammation and neurodegeneration in MS.
Disclosure:
Gabriel Bsteh - conflicts of interest: none.
Harald Hegen - conflicts of interest: none.
Klaus Berek - conflicts of interest: none.
Felix Ladstätter - conflicts of interest: none.
Matthias Amprosi - conflicts of interest: none.
Sebastian Wurth - conflicts of interest: none.
Michael Auer - conflicts of interest: none.
Franziska Di Pauli - conflicts of interest: none.
Florian Deisenhammer - conflicts of interest: none.
Markus Reindl - conflicts of interest: none.
Thomas Berger - conflicts of interest: none.
Andreas Lutterotti - conflicts of interest: none.