Contributions
Abstract: P607
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 23 Neurophysiology
The triple stimulation technique (TST) enables a functional quantification of the central motor conduction failure through the resynchronization of the motor neurones discharges along the corticospinal pathway. Unlike classical motor evoked potentials (MEP), TST is rarely used in the clinical setting of multiple sclerosis (MS), despite a likely strong link with the central axonal loss.
Central motor conduction of 28 consecutive MS patients (median EDSS 4) was prospectively and transversely assessed, based on classical motor evoked potentials (four limbs) and TST (upper limbs). In the same time, disability (Expanded Disability Status Scale), grasping strength (JAMAR dynamometer) and motor components of the multiple sclerosis functional composite (MSFCm) clinical scale, consisting of the hand dexterity (9-hole peg test) and the walking speed (Timed 25 foot walk), were evaluated. The Spearman correlation (rS) was used to evaluate the relationship between MEP, TST and clinical findings.
Central motor conduction time and amplitude of MEP (upper and lower limbs) significantly correlated with MSFCm (0.43 ≤ rS ≤ 0.61) and EDSS (0.57 ≤ rS ≤ 0.64). Correlations between TST and MSFCm (0.59 ≤ rS ≤ 0.69), TST and grasping strength (rS = 0.51) or TST and EDSS (rS = 0.75) were even higher.
The good correlations observed with the EDSS and clinimetry underline the value of classical MEP parameters as a quantitative tool for the functional assessment. The TST, focused on the upper limbs, appears to reflect a global disability since it is correlated not only to the hand dexterity and grasping strength but also to the walking capacity. The TST allows a quantification of the central motor conduction failure, which could be a key surrogate marker in MS, but need further validation through a confrontation with quantitative metrics provided by magnetic resonance imagery.
Keywords: Triple stimulation technique, Motor evoked potentials, Multiple sclerosis, Axonopathy, Disability, Multiple sclerosis functional composite
Disclosure:
Xavier Giffroy: nothing to disclose
François Wang: nothing to disclose
Catherine Göbels: nothing to disclose
Christine Ernon: nothing to disclose
Dominique Dive: nothing to disclose
Abstract: P607
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 23 Neurophysiology
The triple stimulation technique (TST) enables a functional quantification of the central motor conduction failure through the resynchronization of the motor neurones discharges along the corticospinal pathway. Unlike classical motor evoked potentials (MEP), TST is rarely used in the clinical setting of multiple sclerosis (MS), despite a likely strong link with the central axonal loss.
Central motor conduction of 28 consecutive MS patients (median EDSS 4) was prospectively and transversely assessed, based on classical motor evoked potentials (four limbs) and TST (upper limbs). In the same time, disability (Expanded Disability Status Scale), grasping strength (JAMAR dynamometer) and motor components of the multiple sclerosis functional composite (MSFCm) clinical scale, consisting of the hand dexterity (9-hole peg test) and the walking speed (Timed 25 foot walk), were evaluated. The Spearman correlation (rS) was used to evaluate the relationship between MEP, TST and clinical findings.
Central motor conduction time and amplitude of MEP (upper and lower limbs) significantly correlated with MSFCm (0.43 ≤ rS ≤ 0.61) and EDSS (0.57 ≤ rS ≤ 0.64). Correlations between TST and MSFCm (0.59 ≤ rS ≤ 0.69), TST and grasping strength (rS = 0.51) or TST and EDSS (rS = 0.75) were even higher.
The good correlations observed with the EDSS and clinimetry underline the value of classical MEP parameters as a quantitative tool for the functional assessment. The TST, focused on the upper limbs, appears to reflect a global disability since it is correlated not only to the hand dexterity and grasping strength but also to the walking capacity. The TST allows a quantification of the central motor conduction failure, which could be a key surrogate marker in MS, but need further validation through a confrontation with quantitative metrics provided by magnetic resonance imagery.
Keywords: Triple stimulation technique, Motor evoked potentials, Multiple sclerosis, Axonopathy, Disability, Multiple sclerosis functional composite
Disclosure:
Xavier Giffroy: nothing to disclose
François Wang: nothing to disclose
Catherine Göbels: nothing to disclose
Christine Ernon: nothing to disclose
Dominique Dive: nothing to disclose