Contributions
Abstract: P604
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Objective: To explore the potential relationship between objective OCT outcomes and fatigue and depression in people with Multiple Sclerosis (PwMS).
Background: Multiple Sclerosis is characterized by relapses and progression and disease burden is quantified by EDSS/MRI. Fatigue and depression frequently reported in PwMS can be severe/disabling but is not addressed by either measure. Patient reported outcomes (PRO) are utilized to evaluate/track such PwMS symptoms. Objective analysis of disease impact by MRI lesion burden/changes has improved treatment decisions but does not track with PwMS PRO and EDSS. OCT provides additional objective information about disease in PwMS. A relationship between OCT and PRO in PwMS might provide additional proxy measurements to better understand/predict disease impact.
Methods: Retrospective review of PwMS who prospectively completed both OCT testing and PRO Modified Fatigue Impact Scale (MFIS) and Beck's Depression Index (BDI). Linear regression modeling was used to analyze significant relationships between BDI, Rasch-corrected global (MFIS-G), physical (MFIS-P) and cognitive (MFIS-C) fatigue scores, and OCT outcomes [retinal nerve fiber layer-global (RNFL-G) and nasal/temporal ratio (RNFL-N/T), Perimacular Bundle (PMB) and Macular Volume (MV)] for each eye and inter-ocular asymmetry. Significance was set at p< 0.01.
Results: PwMS N=103, 76.9% female, average age = 50.4±10.3. PRO MFIS-C in PwMS significantly correlated (p< 0.01) with: RNFL-G OD (p=0.004, r=0.28), and PMB OS (p=0.005, r=0.28). MFIS-G, and MFIS-P, and Depression scores were not significantly associated with any OCT outcome measurement (although depression correlations approached significance with RNFL-G OD and PMB OS).
Conclusions: OCT findings related to the degree of axonal damage identified significantly correlated with PRO cognitive fatigue in PwMS. No OCT outcomes were found to be correlated with either MFIS-G, MFIS-P, or BDI. “Fatigue” as a construct should not be exclusively measured as a global outcome, as fatigue subtypes can manifest independently and likely impact PwMS Quality of Life differently.
Disclosure: This study was not supported by any outside funding.
Tabiri K: nothing to disclose
Srinivasan J: nothing to disclose
Wissemann K: nothing to disclose
Anand D: nothing to disclose
Fafard L: nothing to disclose
Bumstead B: nothing to disclose
Buhse M: nothing to disclose
Zarif M: nothing to disclose
Blitz K: nothing to disclose
Sergott R: is a consultant to Heidelberg Engineering
Gudesblatt M: nothing to disclose
Abstract: P604
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Objective: To explore the potential relationship between objective OCT outcomes and fatigue and depression in people with Multiple Sclerosis (PwMS).
Background: Multiple Sclerosis is characterized by relapses and progression and disease burden is quantified by EDSS/MRI. Fatigue and depression frequently reported in PwMS can be severe/disabling but is not addressed by either measure. Patient reported outcomes (PRO) are utilized to evaluate/track such PwMS symptoms. Objective analysis of disease impact by MRI lesion burden/changes has improved treatment decisions but does not track with PwMS PRO and EDSS. OCT provides additional objective information about disease in PwMS. A relationship between OCT and PRO in PwMS might provide additional proxy measurements to better understand/predict disease impact.
Methods: Retrospective review of PwMS who prospectively completed both OCT testing and PRO Modified Fatigue Impact Scale (MFIS) and Beck's Depression Index (BDI). Linear regression modeling was used to analyze significant relationships between BDI, Rasch-corrected global (MFIS-G), physical (MFIS-P) and cognitive (MFIS-C) fatigue scores, and OCT outcomes [retinal nerve fiber layer-global (RNFL-G) and nasal/temporal ratio (RNFL-N/T), Perimacular Bundle (PMB) and Macular Volume (MV)] for each eye and inter-ocular asymmetry. Significance was set at p< 0.01.
Results: PwMS N=103, 76.9% female, average age = 50.4±10.3. PRO MFIS-C in PwMS significantly correlated (p< 0.01) with: RNFL-G OD (p=0.004, r=0.28), and PMB OS (p=0.005, r=0.28). MFIS-G, and MFIS-P, and Depression scores were not significantly associated with any OCT outcome measurement (although depression correlations approached significance with RNFL-G OD and PMB OS).
Conclusions: OCT findings related to the degree of axonal damage identified significantly correlated with PRO cognitive fatigue in PwMS. No OCT outcomes were found to be correlated with either MFIS-G, MFIS-P, or BDI. “Fatigue” as a construct should not be exclusively measured as a global outcome, as fatigue subtypes can manifest independently and likely impact PwMS Quality of Life differently.
Disclosure: This study was not supported by any outside funding.
Tabiri K: nothing to disclose
Srinivasan J: nothing to disclose
Wissemann K: nothing to disclose
Anand D: nothing to disclose
Fafard L: nothing to disclose
Bumstead B: nothing to disclose
Buhse M: nothing to disclose
Zarif M: nothing to disclose
Blitz K: nothing to disclose
Sergott R: is a consultant to Heidelberg Engineering
Gudesblatt M: nothing to disclose