Contributions
Abstract: P593
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Background: Multiple Sclerosis (MS) is characterized by alterations in brain structural integrity and worsening of motor performance.
Objectives: We applied structural MRI techniques in a large cohort of MS patients to evaluate the correlation between abnormalities of regional brain gray matter (GM) volumes and white matter (WM) architecture and measures of manual dexterity and Expanded Disability Status Scale (EDSS).
Methods: From 134 HC and 366 right-handed MS patients, brain 3D T1-weighted and diffusion tensor (DT) MRI scans were acquired and used to performed a Voxel-based Morphometry and a Tract-based Spatial Statistic. Correlations between altered MRI measures and EDSS as well as manual dexterity tests [9 Hole Peg Test (9HPT) and Finger Tapping (FT) test] were investigated.
Results: Compared with HC, MS patients show a widespread pattern of GM atrophy involving the frontal, parietal and occipital lobes. The analysis of WM architecture showed a distributed reduction of fractional anisotropy (FA) and an increased axial (AD), radial (RD) and mean diffusivity (MD) in MS patients compared to HC. In MS patients, better performance at 9HPT correlated with higher volume of the putamen, insula and cerebellum, whereas lower 9HPT performance correlated with R cerebellum atrophy. Better FT performance correlated with higher left superior temporal gyrus volume, whereas higher EDSS correlated with atrophy of the cerebellum, temporal lobe and putamen. Finally, a negative correlation between reduced FA and increased AD, RD and MD with worse manual dexterity performances was found.
Conclusions: Tissue loss and microscopic tissue abnormalities of the cerebellum and deep GM structures contributes to explain motor dysfunction in patients with MS.
Disclosure:
C. Cordani, C. Piazza, M. Roselli, F. Esposito, M. Radaelli, B. Colombo have nothing to disclose.
G. Comi, has received compensation for consulting services for Novartis, Teva, Sanofi, Genzyme, Merck, Biogen, Excemed, Roche, Almirall, Chugai, Receptos, and Forward Pharma, and compensation for speaking activities for Novartis, Teva, Sanofi, Genzyme, Merck, Biogen, Excemed, and Roche.
M. Filippi is Editor-in-Chief of the Journal of Neurology; serves on a scientific advisory board for Teva Pharmaceutical Industries; has received compensation for consulting services and/or speaking activities from Biogen Idec, Merck-Serono, Novartis, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Teva Pharmaceutical Industries, Novartis, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, Cure PSP, Alzheimer´s Drug Discovery Foundation (ADDF), the Jacques and Gloria Gossweiler Foundation (Switzerland), and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
M.A. Rocca received speakers honoraria from Biogen Idec, Novartis, Teva Neurosciences and Genzyme and receives research support from the Italian Ministry of Health and Fondazione Italiana Sclerosi Multipla.
Abstract: P593
Type: Poster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Background: Multiple Sclerosis (MS) is characterized by alterations in brain structural integrity and worsening of motor performance.
Objectives: We applied structural MRI techniques in a large cohort of MS patients to evaluate the correlation between abnormalities of regional brain gray matter (GM) volumes and white matter (WM) architecture and measures of manual dexterity and Expanded Disability Status Scale (EDSS).
Methods: From 134 HC and 366 right-handed MS patients, brain 3D T1-weighted and diffusion tensor (DT) MRI scans were acquired and used to performed a Voxel-based Morphometry and a Tract-based Spatial Statistic. Correlations between altered MRI measures and EDSS as well as manual dexterity tests [9 Hole Peg Test (9HPT) and Finger Tapping (FT) test] were investigated.
Results: Compared with HC, MS patients show a widespread pattern of GM atrophy involving the frontal, parietal and occipital lobes. The analysis of WM architecture showed a distributed reduction of fractional anisotropy (FA) and an increased axial (AD), radial (RD) and mean diffusivity (MD) in MS patients compared to HC. In MS patients, better performance at 9HPT correlated with higher volume of the putamen, insula and cerebellum, whereas lower 9HPT performance correlated with R cerebellum atrophy. Better FT performance correlated with higher left superior temporal gyrus volume, whereas higher EDSS correlated with atrophy of the cerebellum, temporal lobe and putamen. Finally, a negative correlation between reduced FA and increased AD, RD and MD with worse manual dexterity performances was found.
Conclusions: Tissue loss and microscopic tissue abnormalities of the cerebellum and deep GM structures contributes to explain motor dysfunction in patients with MS.
Disclosure:
C. Cordani, C. Piazza, M. Roselli, F. Esposito, M. Radaelli, B. Colombo have nothing to disclose.
G. Comi, has received compensation for consulting services for Novartis, Teva, Sanofi, Genzyme, Merck, Biogen, Excemed, Roche, Almirall, Chugai, Receptos, and Forward Pharma, and compensation for speaking activities for Novartis, Teva, Sanofi, Genzyme, Merck, Biogen, Excemed, and Roche.
M. Filippi is Editor-in-Chief of the Journal of Neurology; serves on a scientific advisory board for Teva Pharmaceutical Industries; has received compensation for consulting services and/or speaking activities from Biogen Idec, Merck-Serono, Novartis, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Teva Pharmaceutical Industries, Novartis, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, Cure PSP, Alzheimer´s Drug Discovery Foundation (ADDF), the Jacques and Gloria Gossweiler Foundation (Switzerland), and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
M.A. Rocca received speakers honoraria from Biogen Idec, Novartis, Teva Neurosciences and Genzyme and receives research support from the Italian Ministry of Health and Fondazione Italiana Sclerosi Multipla.