Contributions
Abstract: P409
Type: Poster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Background: Multiple sclerosis (MS) is associated with an increased risk of morbidity due to complications of the disease itself and to treatments.
Typically, the most common cause of morbidity and mortality has been complicated infections in patients with a more severe disability but, in the last decade, other causes associated to new therapies have increased.
Objectives: To compare the morbidity spectrum and mortality in MS patients between two different periods of nine years.
Methods: Retrospective study that includes all MS patients treated at the MS Unit of the Virgen de la Arrixaca Hospital, in Spain, from 1998 to 2016. We have analyzed their demographic and MS characteristics, and we have compared morbidity causes in two nine-year periods: 1998- 2007 and 2007-2016.
Results: In the first period there were 313 MS patients with an average age of 39 (SD 6.8) and EDSS 4.3 (SD 2.5); 450 MS patients in the second group with an average age of 45 (SD 9.8) and EDSS 4 (SD 2). The mean duration of the MS was longer in the second group.
In the first group, the main cause of morbidity related with MS was urinary infection followed by respiratory infection. There were three patients with epileptic seizures and one with posterior reversible encephalopathy related to interferon. There were two women with breast cancer.
In the second group, the main cause was urinary infection followed by alterations in red and white blood count, hepatic damage, herpetic reactivation, autoimmune disease (idiopathic thrombocytopenic purpura, thyroiditis) and opportunistic infection (leishmaniasis, pneumocystis and herpetic encephalitis). In this group there were two breast-, one ovarian- and one testicular tumour.
Conclusions: MS patients are suffering a change in the main causes of morbidity due to the complications arising from new and emergent therapies.
Opportunistic infections and hematological complications are emerging in the last years as frequent side effects in MS patients, which forces the neurologist to a deepest knowledge of this pathologies.
Disclosure:
Rocio Hernandez Clares: nothing to disclose
Ester Carreon Guarnizo: nothing to disclose
Ana E. Baidez Guerrero: nothing to disclose
Gabriel Valero Lopez: nothing to disclose
Estefania García Molina: nothing to disclose
Rosa Sanchez Galvez:nothing to disclose
Joaquin Zamarro Parra: nothing to disclose
Adelaida Leon Hernandez: nothing to disclose
Francisca Velazquez Marin: nothing to disclose
Jose E Meca Lallana: nothing to disclose
Abstract: P409
Type: Poster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Background: Multiple sclerosis (MS) is associated with an increased risk of morbidity due to complications of the disease itself and to treatments.
Typically, the most common cause of morbidity and mortality has been complicated infections in patients with a more severe disability but, in the last decade, other causes associated to new therapies have increased.
Objectives: To compare the morbidity spectrum and mortality in MS patients between two different periods of nine years.
Methods: Retrospective study that includes all MS patients treated at the MS Unit of the Virgen de la Arrixaca Hospital, in Spain, from 1998 to 2016. We have analyzed their demographic and MS characteristics, and we have compared morbidity causes in two nine-year periods: 1998- 2007 and 2007-2016.
Results: In the first period there were 313 MS patients with an average age of 39 (SD 6.8) and EDSS 4.3 (SD 2.5); 450 MS patients in the second group with an average age of 45 (SD 9.8) and EDSS 4 (SD 2). The mean duration of the MS was longer in the second group.
In the first group, the main cause of morbidity related with MS was urinary infection followed by respiratory infection. There were three patients with epileptic seizures and one with posterior reversible encephalopathy related to interferon. There were two women with breast cancer.
In the second group, the main cause was urinary infection followed by alterations in red and white blood count, hepatic damage, herpetic reactivation, autoimmune disease (idiopathic thrombocytopenic purpura, thyroiditis) and opportunistic infection (leishmaniasis, pneumocystis and herpetic encephalitis). In this group there were two breast-, one ovarian- and one testicular tumour.
Conclusions: MS patients are suffering a change in the main causes of morbidity due to the complications arising from new and emergent therapies.
Opportunistic infections and hematological complications are emerging in the last years as frequent side effects in MS patients, which forces the neurologist to a deepest knowledge of this pathologies.
Disclosure:
Rocio Hernandez Clares: nothing to disclose
Ester Carreon Guarnizo: nothing to disclose
Ana E. Baidez Guerrero: nothing to disclose
Gabriel Valero Lopez: nothing to disclose
Estefania García Molina: nothing to disclose
Rosa Sanchez Galvez:nothing to disclose
Joaquin Zamarro Parra: nothing to disclose
Adelaida Leon Hernandez: nothing to disclose
Francisca Velazquez Marin: nothing to disclose
Jose E Meca Lallana: nothing to disclose