Contributions
Abstract: P401
Type: Poster
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Purpose: The goal of this study was to determine the relations between pattern electroretinogram (PERG) with visual functions and ganglion cell layer thickness in patients with relapsing remitting multiple sclerosis (RRMS).
Method: One hundred forty eight eyes of 74 subjects (46 RRMS patients and 28 healthy controls) were recruited. All patients underwent a complete ophthalmic exam including low contrast visual acuity test. Steady-state PERG (Jorvec Corp) was recorded simultaneously from both eyes from surface electrodes in response to horizontal square-wave gratings presented on a LED visual display (1.6 cycles/deg, 98% contrast, reversal rate 15.63 Hz, 25 degree square field; 800 cd/sqm mean luminance). Binocular low contrast sensitivity tests (2.5% and 1.25%) were conducted by the Sloan low contrast letter chart (Precision Vision, La Salle, IL). The ganglion cell-inner plexiform layer (GCIPL) thickness was measured using Zeiss Cirrus optical coherence tomography.
Results: No differences were observed in the demographic characteristics between RRMS patients and normal control subjects. There were no significant differences in PERG amplitude between RRMS and controls (P > 0.05). However, the PERG phase showed a significant increase in MS compared to control analyzed separately in both eyes (P < 0.05). The averaged phase of both eyes was significantly and negatively related to low contrast visual acuity at 1.25% (r = -0.37, P < 0.05) and GCIPL thickness (r = -0.43, P < 0.05).
Conclusions: Increased PERG phase which related to impaired visual function and thinning of GCIPL thickness may indicate abnormal and disease specific activity of the ganglion cells in patients with RRMS.
Disclosure: All the authors have nothing to disclose.
Abstract: P401
Type: Poster
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Purpose: The goal of this study was to determine the relations between pattern electroretinogram (PERG) with visual functions and ganglion cell layer thickness in patients with relapsing remitting multiple sclerosis (RRMS).
Method: One hundred forty eight eyes of 74 subjects (46 RRMS patients and 28 healthy controls) were recruited. All patients underwent a complete ophthalmic exam including low contrast visual acuity test. Steady-state PERG (Jorvec Corp) was recorded simultaneously from both eyes from surface electrodes in response to horizontal square-wave gratings presented on a LED visual display (1.6 cycles/deg, 98% contrast, reversal rate 15.63 Hz, 25 degree square field; 800 cd/sqm mean luminance). Binocular low contrast sensitivity tests (2.5% and 1.25%) were conducted by the Sloan low contrast letter chart (Precision Vision, La Salle, IL). The ganglion cell-inner plexiform layer (GCIPL) thickness was measured using Zeiss Cirrus optical coherence tomography.
Results: No differences were observed in the demographic characteristics between RRMS patients and normal control subjects. There were no significant differences in PERG amplitude between RRMS and controls (P > 0.05). However, the PERG phase showed a significant increase in MS compared to control analyzed separately in both eyes (P < 0.05). The averaged phase of both eyes was significantly and negatively related to low contrast visual acuity at 1.25% (r = -0.37, P < 0.05) and GCIPL thickness (r = -0.43, P < 0.05).
Conclusions: Increased PERG phase which related to impaired visual function and thinning of GCIPL thickness may indicate abnormal and disease specific activity of the ganglion cells in patients with RRMS.
Disclosure: All the authors have nothing to disclose.