Contributions
Abstract: P396
Type: Poster
Abstract Category: Clinical aspects of MS - 9 Economic burden
Background: Multiple sclerosis (MS) is the leading neurological disorder affecting young adults during the primary productive time of their life, and exerts a significant burden not only on people living with the disease but also on their families, friends, healthcare systems and society as a whole. The objective of this study was to identify the health-related quality of life (HRQoL) attributes associated with work productivity loss and caregiver burden in MS.
Methods: Data were compiled from the national representative cross-sectional Survey on Living with Neurological Conditions in Canada (SLNCC) 2011/12. HRQoL was measured using Health Utilities Index Mark 3 (HUI-3). Work productivity loss was derived from two variables: not currently working because of MS and permanently unable to work because of MS. The frequency of informal care that people living with MS (PwMS) received was used as a surrogate of caregiver burden. Multivariable logistic regression analyses were undertaken to identify the HRQoL attributes associated with work productivity loss and greater caregiver burden.
Results: Our analysis included 530 PwMS, nearly half of whom reported receiving informal care and/or stopped working due to MS. Work productivity loss among PwMS was associated with impaired cognition (adjusted odds ratio [aOR]=1.97; 95% confidence interval [CI] 1.46-2.65), pain/discomfort (aOR=1.57; 95% CI 1.23-2.05), and impaired mobility (aOR=2.45; 95% CI 1.84 -3.25) adjusting for sex, age, education, years living with MS, and comorbidity. Caregiver burden was associated with pain/discomfort (aOR=1.34; 95% CI 1.01-1.77), impaired mobility (aOR=1.36; 95% CI 1.10-1.68) and dexterity (aOR=1.77, 95% CI 1.02-3.06) adjusting for PwMS' sex, age, education, years living with MS, and comorbidity.
Conclusion: People living with MS who report having pain and impaired mobility and dexterity are more likely to require greater informal care; while those who report impaired cognition and mobility and pain are more likely to incur productivity loss. Interventions targeting these HRQoL attributes could contribute to improving overall quality of life of PwMS and also keeping them in the workforce and reducing caregiver burden.
Disclosure:
Funding: This research was supported by funds to the Canadian Research Data Centre Network (CRDCN) from the Social Sciences and Humanities Research Council (SSHRC), the Canadian Institute for Health Research (CIHR), the Canadian Foundation for Innovation (CFI), and Statistics Canada. Although the research and analysis are based on data from Statistics Canada, the opinions expressed do not represent the views of Statistics Canada.
Conflict of interest:
Dr. Hategeka has nothing to disclose.
Dr. Traboulsee has received personal compensation for activities with Genzyme and Roche as a consultant.
Dr. Traboulsee has received research support from Genzyme, Roche, and Chugai.
Dr. Lynd has nothing to disclose.
Abstract: P396
Type: Poster
Abstract Category: Clinical aspects of MS - 9 Economic burden
Background: Multiple sclerosis (MS) is the leading neurological disorder affecting young adults during the primary productive time of their life, and exerts a significant burden not only on people living with the disease but also on their families, friends, healthcare systems and society as a whole. The objective of this study was to identify the health-related quality of life (HRQoL) attributes associated with work productivity loss and caregiver burden in MS.
Methods: Data were compiled from the national representative cross-sectional Survey on Living with Neurological Conditions in Canada (SLNCC) 2011/12. HRQoL was measured using Health Utilities Index Mark 3 (HUI-3). Work productivity loss was derived from two variables: not currently working because of MS and permanently unable to work because of MS. The frequency of informal care that people living with MS (PwMS) received was used as a surrogate of caregiver burden. Multivariable logistic regression analyses were undertaken to identify the HRQoL attributes associated with work productivity loss and greater caregiver burden.
Results: Our analysis included 530 PwMS, nearly half of whom reported receiving informal care and/or stopped working due to MS. Work productivity loss among PwMS was associated with impaired cognition (adjusted odds ratio [aOR]=1.97; 95% confidence interval [CI] 1.46-2.65), pain/discomfort (aOR=1.57; 95% CI 1.23-2.05), and impaired mobility (aOR=2.45; 95% CI 1.84 -3.25) adjusting for sex, age, education, years living with MS, and comorbidity. Caregiver burden was associated with pain/discomfort (aOR=1.34; 95% CI 1.01-1.77), impaired mobility (aOR=1.36; 95% CI 1.10-1.68) and dexterity (aOR=1.77, 95% CI 1.02-3.06) adjusting for PwMS' sex, age, education, years living with MS, and comorbidity.
Conclusion: People living with MS who report having pain and impaired mobility and dexterity are more likely to require greater informal care; while those who report impaired cognition and mobility and pain are more likely to incur productivity loss. Interventions targeting these HRQoL attributes could contribute to improving overall quality of life of PwMS and also keeping them in the workforce and reducing caregiver burden.
Disclosure:
Funding: This research was supported by funds to the Canadian Research Data Centre Network (CRDCN) from the Social Sciences and Humanities Research Council (SSHRC), the Canadian Institute for Health Research (CIHR), the Canadian Foundation for Innovation (CFI), and Statistics Canada. Although the research and analysis are based on data from Statistics Canada, the opinions expressed do not represent the views of Statistics Canada.
Conflict of interest:
Dr. Hategeka has nothing to disclose.
Dr. Traboulsee has received personal compensation for activities with Genzyme and Roche as a consultant.
Dr. Traboulsee has received research support from Genzyme, Roche, and Chugai.
Dr. Lynd has nothing to disclose.