Contributions
Abstract: P395
Type: Poster
Abstract Category: Clinical aspects of MS - 9 Economic burden
Objective: To examine interaction of self-reported physical and cognitive disability on fall risk in a population of PwMS.
Background: Falls are common in PwMS. Falling/injuries in PwMS increase costs. Increasing fear of falling (FOF) restricts activities, independence, and adversely impacts quality of life (QoL). FOF has been shown to correlate with increased falls in PwMS. An increasing risk of falling results from varied factors, but only physical disability is commonly recognized and appreciated. Analysis of physical and cognitive impact related to FOF might provide another metric to evaluate MS impact/progression, treatment efficacy/choice and economic burden of disease impact.
Methods: Retrospective review of PwMS who prospectively completed the Multiple Sclerosis Impact Scale (MSIS-29), Modified Falls Efficacy Scale (MFES), and simple (ADL-S) and complex (ADL-C) Activities of Daily Living scales. MSIS-29 scores included: global score, and physical and cognitive sub-scores. Multivariate linear regression was used for and significance was set at p< 0.01.
Results: 602 PwMS; average age=48.9±11.8, 74.6% female. Significant relationships were identified: MSIS-29 global scores and MFES (r=0.57, p< 0.01), ADL-S (r=0.62, p< 0.01), and ADL-C (r=0.64, p< 0.01). MSIS-29 physical scores and MFES (r=0.64, p< 0.01), ADL-S (r=0.69, p< 0.01), and ADL-C (r=0.71, p< 0.01). MSIS-29 cognitive scores and MFES (r=0.33, p< 0.01), ADL-S (r=0.31, p< 0.01), and ADL-C (r=0.32, p< 0.01)
Conclusions: Global and physical disability scores were strongly associated with fall risk for both simple and complex ADL. However, cognitive disability scores consistently accounted for 30-35% of the change in all three disability outcomes. Not only is cognitive impairment an under-measured and underreported symptom in PwMS, its impact on ADL in this population is under-recognized.
Disclosure: All authors: nothing to disclose
Abstract: P395
Type: Poster
Abstract Category: Clinical aspects of MS - 9 Economic burden
Objective: To examine interaction of self-reported physical and cognitive disability on fall risk in a population of PwMS.
Background: Falls are common in PwMS. Falling/injuries in PwMS increase costs. Increasing fear of falling (FOF) restricts activities, independence, and adversely impacts quality of life (QoL). FOF has been shown to correlate with increased falls in PwMS. An increasing risk of falling results from varied factors, but only physical disability is commonly recognized and appreciated. Analysis of physical and cognitive impact related to FOF might provide another metric to evaluate MS impact/progression, treatment efficacy/choice and economic burden of disease impact.
Methods: Retrospective review of PwMS who prospectively completed the Multiple Sclerosis Impact Scale (MSIS-29), Modified Falls Efficacy Scale (MFES), and simple (ADL-S) and complex (ADL-C) Activities of Daily Living scales. MSIS-29 scores included: global score, and physical and cognitive sub-scores. Multivariate linear regression was used for and significance was set at p< 0.01.
Results: 602 PwMS; average age=48.9±11.8, 74.6% female. Significant relationships were identified: MSIS-29 global scores and MFES (r=0.57, p< 0.01), ADL-S (r=0.62, p< 0.01), and ADL-C (r=0.64, p< 0.01). MSIS-29 physical scores and MFES (r=0.64, p< 0.01), ADL-S (r=0.69, p< 0.01), and ADL-C (r=0.71, p< 0.01). MSIS-29 cognitive scores and MFES (r=0.33, p< 0.01), ADL-S (r=0.31, p< 0.01), and ADL-C (r=0.32, p< 0.01)
Conclusions: Global and physical disability scores were strongly associated with fall risk for both simple and complex ADL. However, cognitive disability scores consistently accounted for 30-35% of the change in all three disability outcomes. Not only is cognitive impairment an under-measured and underreported symptom in PwMS, its impact on ADL in this population is under-recognized.
Disclosure: All authors: nothing to disclose