Contributions
Abstract: P333
Type: Poster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Background: Although the negative impacts of smoking on general health has long been known, research has shown there are significant issues related to outcomes and treatments for People with Multiple Sclerosis (PwMS) who continue to smoke. The MS Register has one of the largest collections of Patient Reported outcome Measures (PRoMS) data from PwMS in the UK.
Objective: Employ the largest collection of PRoMs ever used in such a study to inform clinical anti-smoking interventions to PwMS.
Methods: Three longitudinal PRoMS from the Register were used. The 'baseline' questionnaire (MSLife) has included questions about participant smoking status since 2014. The physical component of the Multiple Sclerosis Impact Scale (MSIS-29) was used to measure disability, and the Hospital Anxiety and Depression Score (HADS) to assess mental wellbeing; both of these have been repeating instruments since 2012. There are multiple responses per participant, therefore fuzzy logic was used to join MSIS and HADS responses where dates were closely matched to the smoking status at baseline.
Results: Total participants providing Smoking data and at least one valid MSIS n= 6021; from this cohort, there were 10,878 survey responses over a period of 3.1 years. Participants with smoking data and a HADS score, n= 6125 with 10,961 responses. Kruskal-Wallis H tests showed a statistically significant difference between the physical portion of the MSIS-29 score (χ2(2) = 147.68, p < 0.001) as well as the total HADS score (χ2(2) =129.08, p < 0.001) for participants with different types of smoking status. Never smokers had a mean MSIS score of 48.4 (s = 19.9) and mean HADS of 28.1 (s = 7.6) while the same mean scores for smokers were 53.5 (s = 19.4) and 30.0 (s = 7.9).
Conclusion: In line with recent research, a change of MSIS of 7.5 has been found to be clinically significant. The higher average score for smokers suggests a real increase in disability for smokers over non-smokers. This study showed a significant difference in self-reported physical disability and for PwMS according to their smoking status. Future work will include an analysis of variance to account for confounders and potential clinical inventions.
Disclosure: This work was funded in its entirety by the UK MS Society, and there are no potential conflicts of interest for any of the named authors.
Abstract: P333
Type: Poster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Background: Although the negative impacts of smoking on general health has long been known, research has shown there are significant issues related to outcomes and treatments for People with Multiple Sclerosis (PwMS) who continue to smoke. The MS Register has one of the largest collections of Patient Reported outcome Measures (PRoMS) data from PwMS in the UK.
Objective: Employ the largest collection of PRoMs ever used in such a study to inform clinical anti-smoking interventions to PwMS.
Methods: Three longitudinal PRoMS from the Register were used. The 'baseline' questionnaire (MSLife) has included questions about participant smoking status since 2014. The physical component of the Multiple Sclerosis Impact Scale (MSIS-29) was used to measure disability, and the Hospital Anxiety and Depression Score (HADS) to assess mental wellbeing; both of these have been repeating instruments since 2012. There are multiple responses per participant, therefore fuzzy logic was used to join MSIS and HADS responses where dates were closely matched to the smoking status at baseline.
Results: Total participants providing Smoking data and at least one valid MSIS n= 6021; from this cohort, there were 10,878 survey responses over a period of 3.1 years. Participants with smoking data and a HADS score, n= 6125 with 10,961 responses. Kruskal-Wallis H tests showed a statistically significant difference between the physical portion of the MSIS-29 score (χ2(2) = 147.68, p < 0.001) as well as the total HADS score (χ2(2) =129.08, p < 0.001) for participants with different types of smoking status. Never smokers had a mean MSIS score of 48.4 (s = 19.9) and mean HADS of 28.1 (s = 7.6) while the same mean scores for smokers were 53.5 (s = 19.4) and 30.0 (s = 7.9).
Conclusion: In line with recent research, a change of MSIS of 7.5 has been found to be clinically significant. The higher average score for smokers suggests a real increase in disability for smokers over non-smokers. This study showed a significant difference in self-reported physical disability and for PwMS according to their smoking status. Future work will include an analysis of variance to account for confounders and potential clinical inventions.
Disclosure: This work was funded in its entirety by the UK MS Society, and there are no potential conflicts of interest for any of the named authors.