Contributions
Abstract: P319
Type: Poster
Abstract Category: Clinical aspects of MS - 3 Paediatric MS
Background: Compared to adult-onset MS, paediatric-onset MS (POMS) patients exhibit a more inflammatory disease course with a higher frequency of clinical relapses, a greater burden of infratentorial lesions, and an overall higher brain lesion volume. Despite this, POMS patients tend to have characteristically low levels of sustained disability within the first 10 years of disease. As a result, objective measures of physical disability are considered largely unreliable in this population. Continuous accelerometry represents a novel candidate measure for detecting mild physical disability in paediatric MS subjects.
Design and methods: 21 POMS and 50 healthy controls were recruited from the University of Virginia's Paediatric MS Clinic and the local community, respectively. Subjects completed surveys on physical activity (International Physical Activity Questionnaire (IPAQ) and factors affecting activity levels (Modified Fatigue Impact Scale (MFIS), Beck's Depression Inventory). All subjects completed timed walking tests (2-minute (2MW) and 6-minute (6MW) walks) and 7-day waist-worn continuous accelerometry.
Results: Baseline demographics of sex, age, race, and smoking history were not different between groups; however, POMS subjects had higher rates of obesity (p=0.01). POMS subjects had a median Expanded Disability Status Scale (EDSS) score of 1.5 (range: 0-3). Cases and controls reported similar physical activity levels as measured by IPAQ (p=0.61), but POMS subjects reported significantly higher levels of physical fatigue on MFIS (8.0 ±7.2 vs 4.6 ±5.3; p=0.03). Of timed walking tests, the 6MW performance best distinguished POMS subjects from controls (p=0.027). There were no significant differences between groups on continuous accelerometry-derived measures, including daily steps, time spent in vigorous or moderate activity, and maximum step rate (MSR). In both groups, obesity negatively impacted subject MSR, but with a more pronounced effect in POMS subjects (r= -0.62; p=0.003).
Conclusions: POMS subjects subjectively experience more fatigue but do not report lower levels of physical activity compared to healthy peers. Timed walking tests are potentially useful measures in POMS, but 7-day continuous accelerometry did not distinguish POMS from healthy peers.
Disclosure:
J. N. Brenton: Nothing to disclose
M. Engelhard: Nothing to disclose
H. Koshiba: Nothing to disclose
E. Woolbright: Nothing to disclose
G. Herod: Nothing to disclose
C. Engel: Nothing to disclose
M.D. Goldman: Nothing to disclose
Abstract: P319
Type: Poster
Abstract Category: Clinical aspects of MS - 3 Paediatric MS
Background: Compared to adult-onset MS, paediatric-onset MS (POMS) patients exhibit a more inflammatory disease course with a higher frequency of clinical relapses, a greater burden of infratentorial lesions, and an overall higher brain lesion volume. Despite this, POMS patients tend to have characteristically low levels of sustained disability within the first 10 years of disease. As a result, objective measures of physical disability are considered largely unreliable in this population. Continuous accelerometry represents a novel candidate measure for detecting mild physical disability in paediatric MS subjects.
Design and methods: 21 POMS and 50 healthy controls were recruited from the University of Virginia's Paediatric MS Clinic and the local community, respectively. Subjects completed surveys on physical activity (International Physical Activity Questionnaire (IPAQ) and factors affecting activity levels (Modified Fatigue Impact Scale (MFIS), Beck's Depression Inventory). All subjects completed timed walking tests (2-minute (2MW) and 6-minute (6MW) walks) and 7-day waist-worn continuous accelerometry.
Results: Baseline demographics of sex, age, race, and smoking history were not different between groups; however, POMS subjects had higher rates of obesity (p=0.01). POMS subjects had a median Expanded Disability Status Scale (EDSS) score of 1.5 (range: 0-3). Cases and controls reported similar physical activity levels as measured by IPAQ (p=0.61), but POMS subjects reported significantly higher levels of physical fatigue on MFIS (8.0 ±7.2 vs 4.6 ±5.3; p=0.03). Of timed walking tests, the 6MW performance best distinguished POMS subjects from controls (p=0.027). There were no significant differences between groups on continuous accelerometry-derived measures, including daily steps, time spent in vigorous or moderate activity, and maximum step rate (MSR). In both groups, obesity negatively impacted subject MSR, but with a more pronounced effect in POMS subjects (r= -0.62; p=0.003).
Conclusions: POMS subjects subjectively experience more fatigue but do not report lower levels of physical activity compared to healthy peers. Timed walking tests are potentially useful measures in POMS, but 7-day continuous accelerometry did not distinguish POMS from healthy peers.
Disclosure:
J. N. Brenton: Nothing to disclose
M. Engelhard: Nothing to disclose
H. Koshiba: Nothing to disclose
E. Woolbright: Nothing to disclose
G. Herod: Nothing to disclose
C. Engel: Nothing to disclose
M.D. Goldman: Nothing to disclose