Contributions
Abstract: EP1847
Type: ePoster
Abstract Category: Therapy - symptomatic - 35 Enhancing CNS plasticity
Background: Regular physical activity and physiotherapy accelerate the ability of the brain to slow down clinical progression in people with multiple sclerosis (MS). It positively influences impaired clinical functions, fatigue, mental and cognitive functions and the quality of live in the general. But the mechanism of this recovery is still not well described. For a better understanding of the pathophysiological and consequent reparative processes in MS are nowadays widely used imaging methods.
Aims: In this study, we want to focus on further in-depth understanding of the mechanism of neuroplasticity in people with MS, in terms of monitoring brain connectivity (centrality, regional homogeneity - REHO) in rest (resting state fMRI) - compared with healthy individuals. Further to describe changes in these reactions after ambulatory facilitation physiotherapy.
Methods: 39 patients with MS (mean age 46.7±12.3, Expanded Disability Status Scale - EDSS 4.3±1.7, disease duration 12.1±7.2 years) and 42 healthy volunteers (mean age 43.7±14.8 years) participated in the study. People with MS underwent a two-month program of facilitation physiotherapy
(2x a week, 1 hour). The resting state examination was performed at the beginning and at the end of the therapeutic program.
Results: The regional homogeneity (REHO) is more pronounced in the areas of occipital lobe (gyrus fusiform), frontal lobe (superior frontal gyrus) and temporal lobe (inferior temporal gyrus) in patients with MS. On the other side healthy controls have higher REHO in cerebellum and in parietal areas (supramarginal and angular gyrus) and limbic areas (posterior cingulate gyrus). The REHO parameter was not changed after the physiotherapy. The parameter of centrality was positively higher in healthy controls in areas of parietal lobus (superior parietal gyrus), subcortical grey nuclei (nucleus caudatus) and thalamus. After physiotherapy, the centrality was more pronounced in cerebellum, temporal lobe (inferior temporal gyrus) and parietal lobe (supramarginal gyrus).
Conclusions: There were found differences in connectivity measures as REHO and centrality between patients with MS and healthy controls. The REHO stayed unchanged after physiotherapy, while the degree of centrality slightly increased.
The study was realized due to the support of the Grant Agency, Czech Republic GA13-23940S, 260388/SVV/2017 and Progres Q35.
Disclosure:
Prochazkova M: nothing to disclose
Tintera J: nothing to disclose
Spanhelova S: nothing to disclose
Prokopiusova T: nothing to disclose
Angelova G: nothing to disclose
Rydlo J: nothing to disclose
Rasova K: nothing to disclose
Abstract: EP1847
Type: ePoster
Abstract Category: Therapy - symptomatic - 35 Enhancing CNS plasticity
Background: Regular physical activity and physiotherapy accelerate the ability of the brain to slow down clinical progression in people with multiple sclerosis (MS). It positively influences impaired clinical functions, fatigue, mental and cognitive functions and the quality of live in the general. But the mechanism of this recovery is still not well described. For a better understanding of the pathophysiological and consequent reparative processes in MS are nowadays widely used imaging methods.
Aims: In this study, we want to focus on further in-depth understanding of the mechanism of neuroplasticity in people with MS, in terms of monitoring brain connectivity (centrality, regional homogeneity - REHO) in rest (resting state fMRI) - compared with healthy individuals. Further to describe changes in these reactions after ambulatory facilitation physiotherapy.
Methods: 39 patients with MS (mean age 46.7±12.3, Expanded Disability Status Scale - EDSS 4.3±1.7, disease duration 12.1±7.2 years) and 42 healthy volunteers (mean age 43.7±14.8 years) participated in the study. People with MS underwent a two-month program of facilitation physiotherapy
(2x a week, 1 hour). The resting state examination was performed at the beginning and at the end of the therapeutic program.
Results: The regional homogeneity (REHO) is more pronounced in the areas of occipital lobe (gyrus fusiform), frontal lobe (superior frontal gyrus) and temporal lobe (inferior temporal gyrus) in patients with MS. On the other side healthy controls have higher REHO in cerebellum and in parietal areas (supramarginal and angular gyrus) and limbic areas (posterior cingulate gyrus). The REHO parameter was not changed after the physiotherapy. The parameter of centrality was positively higher in healthy controls in areas of parietal lobus (superior parietal gyrus), subcortical grey nuclei (nucleus caudatus) and thalamus. After physiotherapy, the centrality was more pronounced in cerebellum, temporal lobe (inferior temporal gyrus) and parietal lobe (supramarginal gyrus).
Conclusions: There were found differences in connectivity measures as REHO and centrality between patients with MS and healthy controls. The REHO stayed unchanged after physiotherapy, while the degree of centrality slightly increased.
The study was realized due to the support of the Grant Agency, Czech Republic GA13-23940S, 260388/SVV/2017 and Progres Q35.
Disclosure:
Prochazkova M: nothing to disclose
Tintera J: nothing to disclose
Spanhelova S: nothing to disclose
Prokopiusova T: nothing to disclose
Angelova G: nothing to disclose
Rydlo J: nothing to disclose
Rasova K: nothing to disclose