Contributions
Abstract: EP1830
Type: ePoster
Abstract Category: Therapy - symptomatic - 34 Quality of life
Introduction: Multiple sclerosis (MS) not only causes somatic disability but often leads to psychopathological symptoms such as cognitive impairment (CI), depression and fatigue. Benedict et al (2005) showed that CI, depression and fatigue worsen the patients' QoL as much as the physical disability. This study aimed to assess the impact of these symptoms on the patients' QoL during a 1-year follow up.
Patients and methods: We recruited 178 relapsing-remitting and CIS patients to our study from two major MS clinics in Hungary (Szeged, Budapest); 52 were man, 126 women. We utilized the BICAMS battery for cognitive screening, the MSQoL-54 for the assessment of QoL, the FIS questionnaire for measurement of fatigue, and the BDI-II for the assessment of depression. The first evaluation was carried out in 2014-2015, the follow-up period was in 2015-2016, 1-year after the initial tests. For statistical analysis, we developed a linear mixed-effects model.
Results: The mean age at the follow-up of our patients was 44.8±11.4 years, the mean disease duration was 15.3±8.0 years and median EDSS score was 2.0 (range: 0-6.0) points. In our model we found, that the appearance of fatigue significantly (p< 0.05) reduces the patients' QoL in all 14 dimensions measured by the MSQoL-54. Similarly, the appearance depression has a significant (p< 0.05) impact on the patients QoL on 13 of 14 dimensions (except for the “Change in health” dimension; p=0.287). The appearance of CI does not have such a wide impact, but it significantly reduces the patients QoL in the “Physical functioning”, “Social functions” and “Cognitive functions” dimensions (p< 0.05), even if the rate of cognitive impairment is mild.
Discussion: Our findings strongly suggest that the psychopathological changes are heavy factors in determining MS patients' quality of life. Fatigue and depression have particularly strong and wide effects. Also, even mild CI seriously impacts the patients' quality of life on both the social and the physical level.
Disclosure: Tamás Biernacki: nothing to disclose.
Dániel Sandi: nothing to disclose.
Dóra Szekeres: nothing to disclose.
Judit Füvesi: nothing to disclose.
Zsigmond Tamás Kincses: nothing to disclose.
Zsanett Fricska-Nagy: nothing to disclose.
Csilla Rózsa: nothing to disclose.
Krisztián Kása: nothing to disclose.
Judit Matolcsi: nothing to disclose.
Dóra Zboznovits: nothing to disclose.
Zita Burány: nothing to disclose.
Éva Langane: nothing to disclose.
László Vécsei: nothing to disclose.
Krisztina Bencsik
Abstract: EP1830
Type: ePoster
Abstract Category: Therapy - symptomatic - 34 Quality of life
Introduction: Multiple sclerosis (MS) not only causes somatic disability but often leads to psychopathological symptoms such as cognitive impairment (CI), depression and fatigue. Benedict et al (2005) showed that CI, depression and fatigue worsen the patients' QoL as much as the physical disability. This study aimed to assess the impact of these symptoms on the patients' QoL during a 1-year follow up.
Patients and methods: We recruited 178 relapsing-remitting and CIS patients to our study from two major MS clinics in Hungary (Szeged, Budapest); 52 were man, 126 women. We utilized the BICAMS battery for cognitive screening, the MSQoL-54 for the assessment of QoL, the FIS questionnaire for measurement of fatigue, and the BDI-II for the assessment of depression. The first evaluation was carried out in 2014-2015, the follow-up period was in 2015-2016, 1-year after the initial tests. For statistical analysis, we developed a linear mixed-effects model.
Results: The mean age at the follow-up of our patients was 44.8±11.4 years, the mean disease duration was 15.3±8.0 years and median EDSS score was 2.0 (range: 0-6.0) points. In our model we found, that the appearance of fatigue significantly (p< 0.05) reduces the patients' QoL in all 14 dimensions measured by the MSQoL-54. Similarly, the appearance depression has a significant (p< 0.05) impact on the patients QoL on 13 of 14 dimensions (except for the “Change in health” dimension; p=0.287). The appearance of CI does not have such a wide impact, but it significantly reduces the patients QoL in the “Physical functioning”, “Social functions” and “Cognitive functions” dimensions (p< 0.05), even if the rate of cognitive impairment is mild.
Discussion: Our findings strongly suggest that the psychopathological changes are heavy factors in determining MS patients' quality of life. Fatigue and depression have particularly strong and wide effects. Also, even mild CI seriously impacts the patients' quality of life on both the social and the physical level.
Disclosure: Tamás Biernacki: nothing to disclose.
Dániel Sandi: nothing to disclose.
Dóra Szekeres: nothing to disclose.
Judit Füvesi: nothing to disclose.
Zsigmond Tamás Kincses: nothing to disclose.
Zsanett Fricska-Nagy: nothing to disclose.
Csilla Rózsa: nothing to disclose.
Krisztián Kása: nothing to disclose.
Judit Matolcsi: nothing to disclose.
Dóra Zboznovits: nothing to disclose.
Zita Burány: nothing to disclose.
Éva Langane: nothing to disclose.
László Vécsei: nothing to disclose.
Krisztina Bencsik