Contributions
Abstract: EP1815
Type: ePoster
Abstract Category: Therapy - symptomatic - 33 Treatment of specific symptoms
Fampridine may influence upper limb dysfunction, such as strength and even in upper limb tremor. In this study we aimed to assess the effect of Fampridine treatment on upper limb function of persons with multiple sclerosis (PwMS). We also compared the effect of Fampridine on cerebellar and pyramidal dysfunctions. PwMS aged 18 to 60 years followed-up at the Dokuz Eylul MS Center eligible to Fampridine treatment due to ambulatory disabilities and that in addition presented complains in manual function such as lack of coordination, deficits in fine motor skills, difficulties with dressing, writing and/or buttoning, were invited to participate in this study.
A total of 168 patients (109 female) were included in the study. Nine patients were excluded from the study due to early discontinuation of Fampridine because of side effects, or personal considerations. One hundred fifty-nine patients were followed up to 12 months and 151 patients up to 24 months after initiation of the treatment and are included in this study. Seventy-seven (50 female) healthy controls (HCs) were also included. No significant statistical differences between demographic characteristics of these two groups were found. Manual functions were evaluated by 9 Hole Peg Test (9HP) and visual analog scale (VAS) for hand functions. For evaluating the disability EDSS was performed. Cerebellar and pyramidal functional system (FS) scores were compared.
9HPT improved by 19.8% after 1 month of treatment (p=0.004). Improvement was sustained on month 3, 6, 12 and 24. HC 9HPT results were also improved (3.6%) but not statistically significant (p>0.05). VAS improved by 18% after 1 month of treatment (p=0.02). When comparing FSs, patients with 0 to 2 cerebellar FS scores (n=76) were significantly more improved (23.5%) than patients with 3 and up cerebellar FS scores (9.2%) (p< 0.0001).
The results of this study suggest that Fampridine improves manual function of PwMS. Patients with cerebellar dysfunction were also improved but not as much as patients without marked cerebellar impairment. Patients complains in manual functions due to pyramidal dysfunction seems to be more improved in Fampridine treatment then cerebellar dysfunction.
Disclosure:
Serkan Ozakbas: nothing to disclose
Turhan Kahraman: nothing to disclose
Bilge Piri Cinar: nothing to disclose
Abstract: EP1815
Type: ePoster
Abstract Category: Therapy - symptomatic - 33 Treatment of specific symptoms
Fampridine may influence upper limb dysfunction, such as strength and even in upper limb tremor. In this study we aimed to assess the effect of Fampridine treatment on upper limb function of persons with multiple sclerosis (PwMS). We also compared the effect of Fampridine on cerebellar and pyramidal dysfunctions. PwMS aged 18 to 60 years followed-up at the Dokuz Eylul MS Center eligible to Fampridine treatment due to ambulatory disabilities and that in addition presented complains in manual function such as lack of coordination, deficits in fine motor skills, difficulties with dressing, writing and/or buttoning, were invited to participate in this study.
A total of 168 patients (109 female) were included in the study. Nine patients were excluded from the study due to early discontinuation of Fampridine because of side effects, or personal considerations. One hundred fifty-nine patients were followed up to 12 months and 151 patients up to 24 months after initiation of the treatment and are included in this study. Seventy-seven (50 female) healthy controls (HCs) were also included. No significant statistical differences between demographic characteristics of these two groups were found. Manual functions were evaluated by 9 Hole Peg Test (9HP) and visual analog scale (VAS) for hand functions. For evaluating the disability EDSS was performed. Cerebellar and pyramidal functional system (FS) scores were compared.
9HPT improved by 19.8% after 1 month of treatment (p=0.004). Improvement was sustained on month 3, 6, 12 and 24. HC 9HPT results were also improved (3.6%) but not statistically significant (p>0.05). VAS improved by 18% after 1 month of treatment (p=0.02). When comparing FSs, patients with 0 to 2 cerebellar FS scores (n=76) were significantly more improved (23.5%) than patients with 3 and up cerebellar FS scores (9.2%) (p< 0.0001).
The results of this study suggest that Fampridine improves manual function of PwMS. Patients with cerebellar dysfunction were also improved but not as much as patients without marked cerebellar impairment. Patients complains in manual functions due to pyramidal dysfunction seems to be more improved in Fampridine treatment then cerebellar dysfunction.
Disclosure:
Serkan Ozakbas: nothing to disclose
Turhan Kahraman: nothing to disclose
Bilge Piri Cinar: nothing to disclose