Contributions
Abstract: EP1784
Type: ePoster
Abstract Category: Therapy - disease modifying - 31 Treatment of progressive MS
Background: Biotin is vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis and could promote remyelination. One double blind placebo controlled trial showed improvement in a significant proportion of patients with progressive multiple sclerosis (MS). Biotin is available in France in temporary use since July 2015.
Aim: To study baseline characteristics and follow up of patients treated with Biotin in Dijon (Burgundy).
MEthods: We studied all progressive MS treated with biotin for more than 3 months included in EDMUS database. EDMUS is used in Dijon since 2000 and includes patients from burgundy MS center. We calculated number of primary progressive (PP) or secondary progressive (SP) form of MS, mean age and EDSS at biotin initiation, proportion of patients for which biotin was used as add on therapy or with fampyra, number of adverse events, Clinical Global Impression (CGI) Scale assessed by patient..
Results: 154 patients were treated with biotin, 114 had SPMS and 40 PP. The mean age at MS onset was 32.0 and 45.6 years respectively. Mean age at biotin initiation was 57.6 years with mean EDSS at 6.9 for SPMS; 61.6 years and 6.7 for PPMS. The mean duration of treatment was 8.8 months. 35 patients had biotin as add on therapy among SPMS and 12 for PPMS. 19 (16.7%) patients with SPMS reported adverse events (skin rash, hyperpilosity, diarrhea, anxiety asthenia, oedema) and 3 (7.5%) patients with PPMS (abdominal pain, diarrhea, constipation). 42% of patients reported CGI= 4, 39.5% CGI< 4, 18.4% CGI>4. 48 (31.8%) patients were under fampyra and 103 (68.2%) without, those under fampyra reported CGI improvement more frequently (56% versus 32%)
Conclusion: Despite short treatment duration, biotin is well tolerated, and seems more effective among patients under fampyra.
Disclosure: Fromont: nothing to disclose
Gueniat: nothing to disclose
Romain: nothing to disclose
Arjmand: nothing to disclose
Audry: nothing to disclose
Moreau: nothing to disclose
Abstract: EP1784
Type: ePoster
Abstract Category: Therapy - disease modifying - 31 Treatment of progressive MS
Background: Biotin is vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis and could promote remyelination. One double blind placebo controlled trial showed improvement in a significant proportion of patients with progressive multiple sclerosis (MS). Biotin is available in France in temporary use since July 2015.
Aim: To study baseline characteristics and follow up of patients treated with Biotin in Dijon (Burgundy).
MEthods: We studied all progressive MS treated with biotin for more than 3 months included in EDMUS database. EDMUS is used in Dijon since 2000 and includes patients from burgundy MS center. We calculated number of primary progressive (PP) or secondary progressive (SP) form of MS, mean age and EDSS at biotin initiation, proportion of patients for which biotin was used as add on therapy or with fampyra, number of adverse events, Clinical Global Impression (CGI) Scale assessed by patient..
Results: 154 patients were treated with biotin, 114 had SPMS and 40 PP. The mean age at MS onset was 32.0 and 45.6 years respectively. Mean age at biotin initiation was 57.6 years with mean EDSS at 6.9 for SPMS; 61.6 years and 6.7 for PPMS. The mean duration of treatment was 8.8 months. 35 patients had biotin as add on therapy among SPMS and 12 for PPMS. 19 (16.7%) patients with SPMS reported adverse events (skin rash, hyperpilosity, diarrhea, anxiety asthenia, oedema) and 3 (7.5%) patients with PPMS (abdominal pain, diarrhea, constipation). 42% of patients reported CGI= 4, 39.5% CGI< 4, 18.4% CGI>4. 48 (31.8%) patients were under fampyra and 103 (68.2%) without, those under fampyra reported CGI improvement more frequently (56% versus 32%)
Conclusion: Despite short treatment duration, biotin is well tolerated, and seems more effective among patients under fampyra.
Disclosure: Fromont: nothing to disclose
Gueniat: nothing to disclose
Romain: nothing to disclose
Arjmand: nothing to disclose
Audry: nothing to disclose
Moreau: nothing to disclose