Contributions
Abstract: EP1765
Type: ePoster
Abstract Category: Therapy - disease modifying - 30 Tools for detecting therapeutic response
Background: Assessment of maximal oxygen uptake (V̇O2max) during an incremental exercise test is the gold-standard measure of cardiorespiratory fitness (CRF). Exercise training resulting in improved CRF may be a viable therapeutic strategy to improve MS-related symptoms. Although the association between level of disability and V̇O2max has been established in persons with Multiple Sclerosis (PwMS), the long-term repeatability of V̇O2max and its association with changes in other clinical measures is unclear.
Methods: Participants in an ongoing longitudinal study completed year 1 and year 2 physical profiles including assessment of EDSS by a neurologist, completion of the MS Impact Scale-29 (MSIS), walking on an instrumented walkway (Protokinetics, Havertown USA) and maximal incremental exercise tests on the total body recumbent stepper with integrated indirect calorimentry system (AEI technologies, Pittsburgh USA) to record cardiorespiratory parameters.
Results: Twelve (10F) PwMS aged 48±13 years completed year 1 and 2 assessments. EDSS scores ranged from 0 to 6. At initial assessment: V̇O2max, EDSS, MSIS, and walking velocity were 22.6±7.7 ml min-1 kg-1, 2±2, 38±24, 103±30 cm sec-1, respectively. These values indicate low levels of CRF despite preserved walking speed and relatively low levels of disability. V̇O2max was strongly correlated with walking velocity, MSIS, and EDSS (r=0.87, p< 0.01; r=-0.77, p< 0.01; r=-0.60, p=0.041 respectively), which was maintained at 1-year follow-up (r=0.81, p< 0.01; r=-0.82, p< 0.01; r=-0.62, p=0.035). No significant changes in V̇O2max and clinical measures were observed between time periods. It is important to note that the repeatability of V̇O2max over a 12-month period was very high in this cohort with a correlation coefficient of 0.98 and a 95% CI between -0.52 and 1.58 ml min-1 kg-1.
Conclusion: V̇O2max is associated with clinical measures of MS-related disability and is highly repeatable over a 12-month period in this population. Data collection is ongoing.
Disclosure: Nothing to disclose.
Abstract: EP1765
Type: ePoster
Abstract Category: Therapy - disease modifying - 30 Tools for detecting therapeutic response
Background: Assessment of maximal oxygen uptake (V̇O2max) during an incremental exercise test is the gold-standard measure of cardiorespiratory fitness (CRF). Exercise training resulting in improved CRF may be a viable therapeutic strategy to improve MS-related symptoms. Although the association between level of disability and V̇O2max has been established in persons with Multiple Sclerosis (PwMS), the long-term repeatability of V̇O2max and its association with changes in other clinical measures is unclear.
Methods: Participants in an ongoing longitudinal study completed year 1 and year 2 physical profiles including assessment of EDSS by a neurologist, completion of the MS Impact Scale-29 (MSIS), walking on an instrumented walkway (Protokinetics, Havertown USA) and maximal incremental exercise tests on the total body recumbent stepper with integrated indirect calorimentry system (AEI technologies, Pittsburgh USA) to record cardiorespiratory parameters.
Results: Twelve (10F) PwMS aged 48±13 years completed year 1 and 2 assessments. EDSS scores ranged from 0 to 6. At initial assessment: V̇O2max, EDSS, MSIS, and walking velocity were 22.6±7.7 ml min-1 kg-1, 2±2, 38±24, 103±30 cm sec-1, respectively. These values indicate low levels of CRF despite preserved walking speed and relatively low levels of disability. V̇O2max was strongly correlated with walking velocity, MSIS, and EDSS (r=0.87, p< 0.01; r=-0.77, p< 0.01; r=-0.60, p=0.041 respectively), which was maintained at 1-year follow-up (r=0.81, p< 0.01; r=-0.82, p< 0.01; r=-0.62, p=0.035). No significant changes in V̇O2max and clinical measures were observed between time periods. It is important to note that the repeatability of V̇O2max over a 12-month period was very high in this cohort with a correlation coefficient of 0.98 and a 95% CI between -0.52 and 1.58 ml min-1 kg-1.
Conclusion: V̇O2max is associated with clinical measures of MS-related disability and is highly repeatable over a 12-month period in this population. Data collection is ongoing.
Disclosure: Nothing to disclose.