Contributions
Abstract: EP1719
Type: ePoster
Abstract Category: Therapy - disease modifying - 29 Risk management for disease modifying treatments
Objective: To examine the specific relationships between global and subscale scores of the MSIS-29 and MMAS-8 in people with Multiple Sclerosis (PwMS).
Background: (PwMS) have multiple treatment choices for disease modifying therapies (DMT). DMT non-adherence and treatment delay impacts outcomes and costs. Adherence can be measured by patient report, observation and refills. With varied DMT choices, routes and frequency, predicted PwMS adherence behavior needs exploration as this might impact choice. Non-adherence factors (purposeful vs. accidental) remains unexplored in PwMS. MMAS-8, a validated 8 point questionnaire, is predictive of: medication adherence, pharmacy fill data, and efficacy, economic outcomes, and can be graded to analyze purposeful and accidental sub-scores of non-adherence. This information, when paired with disability measures, might improve both understanding and addressing PwMS non-adherence, and perhaps resultant related disease progression.
Methods: Retrospective reviews of PwMS who completed MSIS-29 and MMAS-8 on the same day in the course of routine clinical care. Global scores for each scale, MSIS-29 physical and cognitive subscales, and MMAS-8 purposeful and accidental subscales were included. Multivariate regression analysis was used to analyze the relationships between scales. Significance was set at p< 0.01.
Results: 245 PwMS; average age=49.8±10.8, 73.5% female. Significant relationships were as follows: MSIS-29 global with MMAS-8 global (r=0.19, p< 0.01) and accidental (r=0.22, p< 0.001); MSIS-29 physical with MMAS-8 accidental (r=0.17, p< 0.01), and MSIS-29 cognitive with MMAS-8 global (r=0.24, p< 0.001), purposeful (r=0.18, p< 0.01), and accidental (r=0.28, p< 0.00001).
Conclusions: Factors in non-adherence in MS is complex and the most consistent relationships was between accidental non-adherence and self-reported cognitive impairment. Providers should consider therapies that are not self-administered when prescribing DMT to cognitively impaired PwMS.
Disclosure: All authors: nothing to disclose
Abstract: EP1719
Type: ePoster
Abstract Category: Therapy - disease modifying - 29 Risk management for disease modifying treatments
Objective: To examine the specific relationships between global and subscale scores of the MSIS-29 and MMAS-8 in people with Multiple Sclerosis (PwMS).
Background: (PwMS) have multiple treatment choices for disease modifying therapies (DMT). DMT non-adherence and treatment delay impacts outcomes and costs. Adherence can be measured by patient report, observation and refills. With varied DMT choices, routes and frequency, predicted PwMS adherence behavior needs exploration as this might impact choice. Non-adherence factors (purposeful vs. accidental) remains unexplored in PwMS. MMAS-8, a validated 8 point questionnaire, is predictive of: medication adherence, pharmacy fill data, and efficacy, economic outcomes, and can be graded to analyze purposeful and accidental sub-scores of non-adherence. This information, when paired with disability measures, might improve both understanding and addressing PwMS non-adherence, and perhaps resultant related disease progression.
Methods: Retrospective reviews of PwMS who completed MSIS-29 and MMAS-8 on the same day in the course of routine clinical care. Global scores for each scale, MSIS-29 physical and cognitive subscales, and MMAS-8 purposeful and accidental subscales were included. Multivariate regression analysis was used to analyze the relationships between scales. Significance was set at p< 0.01.
Results: 245 PwMS; average age=49.8±10.8, 73.5% female. Significant relationships were as follows: MSIS-29 global with MMAS-8 global (r=0.19, p< 0.01) and accidental (r=0.22, p< 0.001); MSIS-29 physical with MMAS-8 accidental (r=0.17, p< 0.01), and MSIS-29 cognitive with MMAS-8 global (r=0.24, p< 0.001), purposeful (r=0.18, p< 0.01), and accidental (r=0.28, p< 0.00001).
Conclusions: Factors in non-adherence in MS is complex and the most consistent relationships was between accidental non-adherence and self-reported cognitive impairment. Providers should consider therapies that are not self-administered when prescribing DMT to cognitively impaired PwMS.
Disclosure: All authors: nothing to disclose