Contributions
Abstract: EP1591
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: The term “No evidence of disease activity” (NEDA) means no relapses or disability progression and no new/enlarging MRI lesions in relapsing-remitting multiple sclerosis (RRMS). Cognitive progression in these patients has been poorly studied.
Objective: Determine the cognitive evolution in NEDA patients.
Method: RRMS patients were examined at baseline and in the second evaluation (after a one to three years period) with neurological, neuropsychological and structural MRI examinations. Outcomes measures: Neuropsychological assesment: Selective Reminding Test (SRT), 7/24 Visuospatial Test, SDMT and Verbal Fluency, Beck Depression Inventory II (BDI II); Clinical measures: Expanded disability status scale (EDSS).
Results: 15 NEDA patients were described. Age: 37.5 13.9; Female: 8; education: 12.7 2.7 years; EDSS: 3.21.5; disease evolution: 9.18.3 years. When compare cognitive function between both neuropsychological evaluations, NEDA patients show significant low scores in verbal memory (p= .026 and a trend toward worsening in verbal fluency (p= .056).
Conclusions: In our work we have found cognitive changes in NEDA patients. Based on these results, the relevance of cognitive assessment as a marker of disease activity is reaffirmed.
Disclosure: Nothing to disclose
Abstract: EP1591
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: The term “No evidence of disease activity” (NEDA) means no relapses or disability progression and no new/enlarging MRI lesions in relapsing-remitting multiple sclerosis (RRMS). Cognitive progression in these patients has been poorly studied.
Objective: Determine the cognitive evolution in NEDA patients.
Method: RRMS patients were examined at baseline and in the second evaluation (after a one to three years period) with neurological, neuropsychological and structural MRI examinations. Outcomes measures: Neuropsychological assesment: Selective Reminding Test (SRT), 7/24 Visuospatial Test, SDMT and Verbal Fluency, Beck Depression Inventory II (BDI II); Clinical measures: Expanded disability status scale (EDSS).
Results: 15 NEDA patients were described. Age: 37.5 13.9; Female: 8; education: 12.7 2.7 years; EDSS: 3.21.5; disease evolution: 9.18.3 years. When compare cognitive function between both neuropsychological evaluations, NEDA patients show significant low scores in verbal memory (p= .026 and a trend toward worsening in verbal fluency (p= .056).
Conclusions: In our work we have found cognitive changes in NEDA patients. Based on these results, the relevance of cognitive assessment as a marker of disease activity is reaffirmed.
Disclosure: Nothing to disclose