Contributions
Abstract: EP1587
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: There is increasing scientific data that cortical lesions (both number and size) are an independent factor in the pathogenesis of cognitive impairment in multiple sclerosis (MS). Several studies have also linked cortical lesions with disability and evolution to secondary progressive phase of the disease.
Objective: Our study aims to investigate the role of cortical lesions, cortical atrophy and white matter lesions in cognitive decline in patients with MS.
Methods: Fifteen patients with MS underwent clinical, detailed neuropsychological and neuroimaging examination. We performed a 3 Tesla magnetic resonance imaging with three-dimensional double inversion recovery in the sagittal plane added to the standard protocol. The images were reviewed and compared by two radiologists. Lesions were divided into 6 groups and the stage of cortical atrophy was assessed on a scale of 0-4.
Results: Cortical lesion pathology positively correlated with the severity of cortical atrophy (p=0.05) and periventricular white matter lesion load (p< 0.05). Cortical lesions correlated with some cognitive scores including Mini-Mental State (p< 0.05), information processing, measured by Symbol Digit Modalities Test (p=0.05) and verbal fluency (p< 0.05). White matter lesion load correlated with executive functioning, measured by the number of hits (p=0.001) and omissions (p< 0.05) in the Paced Auditory Serial Addition Test and reached near statistical significance for recognition in the Free and Cued Selective Reminding Test (p=0.06). Physical disability, measured by the Expanded Disability Status Scale, correlated with cortical atrophy (p< 0.05).
Conclusion: Our results show that cortical lesion pathology is one of the most sensitive imaging correlates of cognitive dysfunction in MS. Specific tests measuring executive dysfunction may correspond to the different types of imaging pathology and their underlying pathogenic processes.
Disclosure:
T. Kunchev: nothing to disclose
N. Fileva: nothing to disclose
M. Petrova: nothing to disclose
D. Zlatareva: nothing to disclose
L. Traykov: nothing to disclose
Abstract: EP1587
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: There is increasing scientific data that cortical lesions (both number and size) are an independent factor in the pathogenesis of cognitive impairment in multiple sclerosis (MS). Several studies have also linked cortical lesions with disability and evolution to secondary progressive phase of the disease.
Objective: Our study aims to investigate the role of cortical lesions, cortical atrophy and white matter lesions in cognitive decline in patients with MS.
Methods: Fifteen patients with MS underwent clinical, detailed neuropsychological and neuroimaging examination. We performed a 3 Tesla magnetic resonance imaging with three-dimensional double inversion recovery in the sagittal plane added to the standard protocol. The images were reviewed and compared by two radiologists. Lesions were divided into 6 groups and the stage of cortical atrophy was assessed on a scale of 0-4.
Results: Cortical lesion pathology positively correlated with the severity of cortical atrophy (p=0.05) and periventricular white matter lesion load (p< 0.05). Cortical lesions correlated with some cognitive scores including Mini-Mental State (p< 0.05), information processing, measured by Symbol Digit Modalities Test (p=0.05) and verbal fluency (p< 0.05). White matter lesion load correlated with executive functioning, measured by the number of hits (p=0.001) and omissions (p< 0.05) in the Paced Auditory Serial Addition Test and reached near statistical significance for recognition in the Free and Cued Selective Reminding Test (p=0.06). Physical disability, measured by the Expanded Disability Status Scale, correlated with cortical atrophy (p< 0.05).
Conclusion: Our results show that cortical lesion pathology is one of the most sensitive imaging correlates of cognitive dysfunction in MS. Specific tests measuring executive dysfunction may correspond to the different types of imaging pathology and their underlying pathogenic processes.
Disclosure:
T. Kunchev: nothing to disclose
N. Fileva: nothing to disclose
M. Petrova: nothing to disclose
D. Zlatareva: nothing to disclose
L. Traykov: nothing to disclose