Contributions
Abstract: EP1574
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: Changes in information processing speed (IPS) constitute the most important cognitive alteration in multiple sclerosis (MS). However, given the clinical and topographical variability of the disease, cognitive alterations may vary greatly and appear in other forms in addition to slower IPS. Our aim was to determine the principal cognitive domains and components involved in MS and identify factors associated with presence of cognitive impairment in these patients.
Methods: Cross-sectional study of 311 patients with MS (236 with relapsing-remitting MS [RRMS],
52 with secondary progressive MS [SPMS], and 23 with primary progressive MS [PPMS]). Patients' cognitive function was assessed with a comprehensive neuropsychological assessment protocol. We conducted a principal component analysis to detect different cognitive patterns by identifying clusters of tests highly correlated to one another.
Results: Cognitive impairment was detected in 41.5% of the sample and more frequent in patients with SPMS and PPMS (P = 0.002). EDSS scores and education were independent predictors of cognitive impairment. Principal component analysis identified 7 clusters: attention and basic executive function (including IPS), planning and high-level executive function, verbal memory and language, executive and visuospatial performance time, fatigue-depression, visuospatial function, and basic attention and verbal/visual working memory. Mean scoring of components 2 and 3 was higher in patients with RRMS than in those with PPMS (component 2) and SPMS (component 3).
Conclusions: MS is linked to multiple cognitive profiles and alterations in different domains. This suggests that cognitive alterations in MS are heterogeneous and affect other domains in addition to IPS.
Disclosure:
Ana Cortés-Martínez: nothing to disclose
V. Pytel: nothing to disclose
Jordi A. Matias-Guiu: nothing to disclose
María Valles-Salgado: nothing to disclose
C. Oreja-Guevara: nothing to disclose
P. Montero: nothing to disclose
T. Moreno-Ramos: nothing to disclose
J. Matias-Guiu: nothing to disclose
Abstract: EP1574
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: Changes in information processing speed (IPS) constitute the most important cognitive alteration in multiple sclerosis (MS). However, given the clinical and topographical variability of the disease, cognitive alterations may vary greatly and appear in other forms in addition to slower IPS. Our aim was to determine the principal cognitive domains and components involved in MS and identify factors associated with presence of cognitive impairment in these patients.
Methods: Cross-sectional study of 311 patients with MS (236 with relapsing-remitting MS [RRMS],
52 with secondary progressive MS [SPMS], and 23 with primary progressive MS [PPMS]). Patients' cognitive function was assessed with a comprehensive neuropsychological assessment protocol. We conducted a principal component analysis to detect different cognitive patterns by identifying clusters of tests highly correlated to one another.
Results: Cognitive impairment was detected in 41.5% of the sample and more frequent in patients with SPMS and PPMS (P = 0.002). EDSS scores and education were independent predictors of cognitive impairment. Principal component analysis identified 7 clusters: attention and basic executive function (including IPS), planning and high-level executive function, verbal memory and language, executive and visuospatial performance time, fatigue-depression, visuospatial function, and basic attention and verbal/visual working memory. Mean scoring of components 2 and 3 was higher in patients with RRMS than in those with PPMS (component 2) and SPMS (component 3).
Conclusions: MS is linked to multiple cognitive profiles and alterations in different domains. This suggests that cognitive alterations in MS are heterogeneous and affect other domains in addition to IPS.
Disclosure:
Ana Cortés-Martínez: nothing to disclose
V. Pytel: nothing to disclose
Jordi A. Matias-Guiu: nothing to disclose
María Valles-Salgado: nothing to disclose
C. Oreja-Guevara: nothing to disclose
P. Montero: nothing to disclose
T. Moreno-Ramos: nothing to disclose
J. Matias-Guiu: nothing to disclose